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2061. [Oncogens. Their origin, distribution, structure and functions in carcinogenesis].2062. [Oncogens and carcinogenesis].2063. [Proteins and tumor growth].2064. [Modern concepts of the etiology and pathogenesis of lung cancer].2065. [Changes in resistance to tumor development in various strains of mice exposed to immunologic agents during the neonatal period].
In the course of exposures to the immunological agents (BCG, complete Freund's adjuvant) during the postnatal period, the resistance to tumor development induced with chemical carcinogens was found to increase in C57BL/6 mice, particularly in BALB/c and random-bred ones; meanwhile in C3H/He mice it declined. At the same time C3H/He mice showed a decrease in the resistance to the development of spontaneous tumors of the mammary glands. The changes recorded correlated with those seen in the immunocompetent organs.
2066. [Resistance-suppressing activity of transformed Syrian hamster cells and their ability to metastasize].
作者: G I Deĭchman.;T E Kliuchareva.;L M Kashkina.;V A Matveeva.;M A Teplova.
来源: Biull Eksp Biol Med. 1981年92卷11期596-9页
Hamster embryo cells spontaneously transformed in vitro (HETr) with low metastatic activity were not capable to depress natural antitumor resistance in vivo in contrast to some other lines of Syrian hamster tumor cells. The resistance, depressing and metastatic activities of HETr parental cells and their variants obtained from lung metastases were studied and compared. The direct correlation was found between the resistance-depressing and metastatic activities of the cell variants studied. Five of eight cell variants obtained from lung metastases ocf HETr were capable to depress natural host resistance to the growth of transplanted tumor cells. They were the most active variants in the lung colonization test. It is suggested that in the course of metastasizing there takes place the selection of the tumor cell variants capable of depressing natural antitumor host resistance.
2067. [Genome instability and neoplasia].
Necessity of oncogene for the neoplastic cell transformation is substantiated. The oncogene may be introduced into the cell by a virus; be present in the cell from its formation but be repressed by products of regulatory genes; be arisen from separated DNA segments. The latter possibility is discussed in view of data on the presence of mobile elements and Sarc sequences in the cell genome.
2068. [Changes in the ploidies of hepatocyte nuclei of animals with transplantable tumors during liver regeneration and x-irradiation].
Alterations in ploidy of hepatocyte nuclei were followed in experiments on 190 rats with transplantable tumors during liver regeneration and x-ray irradiation. The presence of the growing transplantable tumor in the animal's body led to alterations in the nuclear structure of hepatocytes, manifesting in the increased ploidy. X-Ray irradiation brought about a rise in hepatocyte ploidy which was more remarkable the higher the dose. Under such conditions, polyploidy of hepatocyte nuclei was more pronounced in tumor-bearing rats than in those without tumors. An abrupt increase in ploidy of hepatocyte nuclei occurred in the regenerating liver of tumor-bearing animals both non-irradiated and, particularly, irradiated ones.
2069. [Chromosome aberrations as morphological criteria of the effectiveness of chemotherapy of ovarian tumors].2070. [One of the possible mechanisms of growth regulation in multicellular organisms and its application to the problems of aging and carcinogenesis].2071. [Seroepidemiologic studies in lymphogranulomatosis].
作者: L V Kokosha.;B A Lapin.;V N Lebedev.;N V Danilova.;N N Arshba.
来源: Probl Gematol Pereliv Krovi. 1981年26卷8期12-6页 2072. [Peutz-Jeghers syndrome].2073. [Hereditary changes in Ehrlich tumor cells after the action of x-rays and neutrons].2074. [Effect of thymosin on T- and B-lymphocyte marker expression in chronic lympholeukosis].
作者: S M Shergin.;V P Lozovoĭ.;G Z Shubinskiĭ.;V S Kozhevnikov.;O T Kudaeva.
来源: Probl Gematol Pereliv Krovi. 1981年26卷4期40-4页 2075. [Excretion of the blastomogenic tyrosine metabolite, p-hydroxyphenyllactic acid, in young children with hemoblastoses and their parents].
作者: V D Ivanova.;S A Balakirev.;V N Baĭkova.;S A Maiakova.;I M Vares.
来源: Probl Gematol Pereliv Krovi. 1981年26卷4期22-6页 2076. [Prospects for genetic studies of cancer of the gastrointestinal tract].2077. [Tumoral effects in the progeny produced from irradiated rats].2078. [HL-A antigens in blood system pathology].
作者: A T Tananov.;R M Kut'ina.;N S Turbina.;E M Abakumov.;A M Polianskaia.
来源: Probl Gematol Pereliv Krovi. 1981年26卷1期8-12页 2079. [New developments in cancer cytogenetics].
Three topics are discussed in the review: 1) The non-random and specific chromosome changes in human and animal tumors, 2) prezygotic chromosomal mutations which specifically predispose to some human tumors, and 3) the role of cytogenetics in the discovery and study of a novel phenomenon for mammalian cells-gene amplification which was revealed in a number of tumors and in cell lines resistant to some anticancer drugs.
2080. [Multiple primary bilateral cancer of the breasts]. |