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1801. [Death during treatment with ellipticine].1802. [Epiphysiolysis of the hip following radiotherapy of pelvic tumors in early infancy. Apropos of 5 new cases].
Five personal cases of slipped capital femoral epiphysis in children submitted to pelvic radiotherapy and nineteen similar observations are reported. This complication appears around 6 years after radiotherapy; its frequency increases with high radiations doses and associated chemotherapy. Weakening of the epiphyseal plate is probably involved whatever radiations voltages. Surgical treatments should be confined to epiphysis fixation. As this complication can secondarily affect the other hip, preventive controlateral fixation must be discussed.
1803. [Infertility problems following radiotherapy and chemotherapy for testicular tumors].1804. [Preoperative chemotherapy of ovarian cancer in anesthesia and resuscitation].
Anti-mitotic chemotherapy has become more efficient but also more toxic. This toxicity complicates later operations. Sixty cases of ovarian cancer one analysed and the various complications related to chemotherapy described.
1805. [1 year's use of alizapride for the prevention and treatment of nausea and vomiting secondary to anticancer agents].1806. [Nephrotoxicity of mitomycin C (apropos of 25 case reports). Results of a multicenter survey organized by the Society of Nephrology].
We have studied 25 cases of hemolytic and uremic syndrome (H.U.S.) induced by mitomycin C, collected from 1976 to 1982 in 12 Nephrology Centers. Mitomycin C was administered in successive cures at a cumulative dose higher than 50 mg/m2. This H.U.S. is characterized by its slow and late occurrence, by extra-renal, mainly respiratory, manifestations that may reveal the disease, and finally by its pathological aspects. Mesangiolysis and endothelial or mesangial enlarged and atypical nuclei are observed in addition to the usual lesions of thrombotic micro-angiopathy. The prognosis was very poor in the first cases reported. It was better, however, in the patients studied more recently, because the cumulative dose was lower. In severe cases, plasma exchange might improve long-term prognosis. The disease might be due to a direct toxic effect of mitomycin C on the vascular endothelium.
1807. [Pulmonary changes caused by cytostatic drugs].
About 80 drugs are known to cause lung disease. Cytostatic agents are the most common cause of this type of iatrogenic disease. In addition to the "intercalating" type of cytostatic, other groups, especially the alkylating (busulfan) and the antimetabolites groups (methotrexate), have also been incriminated. Cytostatic drug-induced lung disease is a difficult diagnosis based on the results of clinical, radiological, respiratory function, histopathological and biological investigations. The results of bronchoalveolar lavage are vital, especially in lung disease due to a drug hypersensitivity reaction; the diagnosis of drug-induced pulmonary fibrosis due to a toxic mechanism is much more difficult and risky. Early diagnosis of these drug-induced lung diseases is obviously important.
1808. [Venous occlusive disease of the liver and autologous bone marrow transplantation. Preventive role for heparin?].
作者: J Y Cahn.;M Flesch.;E Plouvier.;P Hervé.;A Rozenbaum.
来源: Nouv Rev Fr Hematol (1978). 1985年27卷1期27-8页
The pathogenesis of veno-occlusive disease (VOD) of the liver remains unclear. In a retrospective study we reviewed 63 patients treated with high dose conditioning regimens followed by autologous bone marrow transplant. All patients were given low dose heparin (1 mg/kg). Only one patient developed VOD when heparin was stopped. We think that low dose heparin seems an interesting proposal for an randomized study to prevent VOD.
1809. [Treatment of acute myeloid leukemia with amsacrine and high-dose cytosine arabinoside: a phase II trial].
Ten patients with acute myeloid leukaemia on failure or relapse were treated by Amsacrine and high-dose (12 g/m2) Cytosine Arabinosyl (phase II trial). Four patients achieved complete remission, over six months in one instance. Hematologic toxicity was important but extra-hematologic toxicity was mild. These two drugs could be used as induction or reinforcement treatment in acute myeloid leukaemia.
1811. [Lipid peroxidation and free radicals. Role in cellular biology and pathology].
Membrane phospholipids attack by oxygen free radicals, i.e. lipidoperoxidation, occurs in normal cellular life. This free radicals attack is controlled by a protective system, both enzymatic (superoxide dismutase, catalase, glutahione peroxidase) and non enzymatic (vitamine E). Imbalance between attack and defense can explain many pathological events. In these events, the oxidation products of unsaturated fatty acids are of fundamental importance, in particular those derived from arachidonic acid (prostaglandins, prostacyclins, thromboxanes and leukotrienes).
1812. [Cancer chemotherapy and anesthesia].1813. [Chemotherapy by ambulatory continuous infusion using a portable pump: a feasibility trial].
作者: M Benahmed.;P Carde.;A Laplanche.;J Renaux.;J Rouesse.;M Spielmann.;H Sancho-Garnier.
来源: Bull Cancer. 1985年72卷1期30-6页
43 metastatic cancer patients received 190 portable infusors over 24 hours or more. This portable infusor is a disposable material made by Travenol which operates without outside energy. The drug in an elastomere balloon reservoir is injected about 24 hours at a rate of 2 ml/hour. We used various drugs: CDDP, bleomycin, 5 fluorouracil, aracytine, velbe, voltarene. The patients were under hospital observation and received their treatment without any incident due to the pump itself. The patients who had already been perfused with the usual technique greatly appreciated the comfort of this light portable device. Our next step will permit us to estimate the use of these infusors by patients at home.
1814. [Characterization of chromosomal aberrations induced in man by various antimitotic agents].
作者: M F Turchini.;A Geneix.;B Perissel.;P Malet.;J P Turchini.
来源: C R Seances Soc Biol Fil. 1985年179卷3期331-9页
Six antitumoral drugs were tested in human lymphocytes cultures. Our observations pointed out specific abnormalities beside more usual chromosomal aberrations. These lesions are mainly telomeric and chromatidic fusions, chromomerisations and despiralizations. We present an interpretation of these abnormalities.
1815. [Decrease in the transforming action of Rous sarcoma virus produced by avian cells grown in the presence of 5'-deoxy-5'-S-isobutyladenosine (SIBA)].
作者: F Presse.;F Lawrence.;A Pierré.;C Tempête.;M Robert-Gero.
来源: C R Acad Sci III. 1985年301卷7期355-60页
Treatment of Rous Sarcoma virus transformed chick embryo fibroblasts with 1 mM 5'-deoxy-5'-S-isobutyladenosine for 24 hrs. leads to the inhibition of transforming virus production. A kinetic analysis of the inhibition of active virion production revealed that the effect of the drug was time and concentration dependent. After 24 hrs. with 1 mM SIBA, the production of transforming virus was inhibited 165 fold. However, under these conditions there was only a 2 fold inhibition in viral particle production. Thus, these viral particles were either non infective (non adsorbed on cell membrane) or non transforming. The majority of viral particles produced by cells cultured with the drug have a decreased density. Analysis of these virions showed a decrease of protein P19 and an accumulation of proteins with high molecular weight.
1816. [Inhibition of DNA repair, major objective of anticancer chemotherapy. Apropos of 680 cases with continuous platin bleomycin combination].
作者: L Israël.;J L Breau.;J F Morere.;E Lepage.;J Aguilera.
来源: Ann Med Interne (Paris). 1985年136卷1期17-20页
Six hundred and eighty seven cases of cancers of various sites, essentially of squamous structure are presented. Their treatment consisted of a combination of cisplatinum, given 5 days in a row every 3 weeks and of continuously infused bleomycin, also 5 days every 3 weeks. Objective (greater than 50 p. 100) regressions were seen in 70 p. 100 of cases, a significantly greater proportion than obtained by other chemotherapies or by cisplatinum and bleomycin given for one day. This difference is attributed to the fact that bleomycin, a potent inhibitor of type II DNA polymerase, inhibits DNA repair. The authors evaluate the extent of DNA repair to be about 80 p. 100 of all the lesions created by platinum salts and consider DNA repair to be a major limitation of cytostatic therapy, often neglected in the design of chemotherapy protocols.
1818. [Veno-occlusive disease following chemotherapy and radiotherapy for Hodgkin's disease].
作者: T Lamy.;E Le Prise.;Y Deugnier.;M Gosselin.;P Y Le Prise.
来源: Gastroenterol Clin Biol. 1984年8卷12期981-2页 1819. [Intestinal complications of chemotherapy in pediatric oncology. Incidence, type, and development].1820. [Cardiovascular effects of elliptinium. The mechanism of action].
The effects of elliptinium were studied: Firstly, in the dog, in comparison with the effects of histamine, on heart rate and arterial blood pressure. Secondly, in guinea-pig isolated atria. When smaller doses were used (0.375; 0.75; 1.5 mg/kg) elliptinium only induced variations of heart rate. With the dose of 3 mg/kg hypotension and tachycardia appeared. The time-course of these effects was different from that of histamine (5 micrograms/kg): later onset and longer duration. Elliptinium was inactive in isolated guinea-pig atria, as observed in tracheal or digestive isolated smooth muscle. Thus, the cardiovascular activity of this antitumoral agent seems to implicate an indirect mechanism of action. This result is in accordance with the previous results obtained on bronchopulmonary system.
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