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1805. [Safety for the handling of cytostatic substances. Protective measures are useful].1806. [Recommendation concerning protective measures. Safety for the handling of cytostatic substances. The current situation--a "Swiss compromise"].1808. [Nephrotoxicity of anti-tumor agents].1809. [The effect of modification of the intracellular distribution of polyamines on the proliferation of hepatocytes treated with 2-methyl-9-hydroxyellipticine].
2-Methyl-9-hydroxyellipticine (MHE) added to tumoral hepatocyte cultures (400 ng MHE/ml medium) is responsible for a cytostatic effect. This decrease of cellular proliferation and of DNA synthesis is accompanied by an increase of intracellular free spermidine levels. We could not attribute this result to a deviation of this polyamine metabolism. These increased concentrations of free spermidine are connected to a decrease of the amount of nuclear bound polyamines, mainly joined with the RNA fraction. Thus, the cytostatic effect observed with this drug might be related to a decrease in the amount of spermidine connected to RNA; therefore, its intercalating effect is only indirectly responsible for the cellular proliferation decrease.
1810. [Drug-induced cochleovestibular pathology].1811. [Leukemias secondary to cytotoxic therapy. Study of 29 cases in Quebec and Montreal].
作者: A de Gramont.;M Bergeron.;Y Drolet.;P Leblond.;E Rioux.;L Desjardins.;M Gyger.;P d'Auteuil.;J M Delâge.
来源: Union Med Can. 1985年114卷4期334-7页 1812. [Medicines: antineoplastic chemotherapy].1813. [Vindesine in oral cancers].
Vindesine, a vinblastine derivative, was evaluated in 36 patients with malignant tumours of the buccal cavity previously untreated. Vindesine was used (1) pre-operatively, in short, weekly intravenous courses for 1 to 3 weeks and (2) prior to radiotherapy of inoperable tumours, in prolonged treatments, either by bolus i.v. injections with vein washing weekly or, in case of failure, by continuous i.v. infusion over 5 days. In the first group major responses were obtained in 22.2% of the cases. In the second group only 1 of 18 patients responded to weekly injections, whereas 3 out of 10 patients responded to continuous infusion (including one complete remission), showing that this mode of administration was more effective than bolus injections. Toxic reactions to the drug are discussed. Venous damage was the predominant complication of continuous infusion.
1814. [Fatal complication during treatment with elliptinium acetate].1815. [Apropos of the nephrotoxicity of antitumoral drug therapy].
作者: D Cordonnier.;J L Alix.;R Schaerer.;P Swiercz.;P Vialtel.;F Bayle.
来源: Presse Med. 1985年14卷1期51页 1816. [Death during treatment with ellipticine].1817. [Epiphysiolysis of the hip following radiotherapy of pelvic tumors in early infancy. Apropos of 5 new cases].
Five personal cases of slipped capital femoral epiphysis in children submitted to pelvic radiotherapy and nineteen similar observations are reported. This complication appears around 6 years after radiotherapy; its frequency increases with high radiations doses and associated chemotherapy. Weakening of the epiphyseal plate is probably involved whatever radiations voltages. Surgical treatments should be confined to epiphysis fixation. As this complication can secondarily affect the other hip, preventive controlateral fixation must be discussed.
1818. [Infertility problems following radiotherapy and chemotherapy for testicular tumors].1819. [Preoperative chemotherapy of ovarian cancer in anesthesia and resuscitation].
Anti-mitotic chemotherapy has become more efficient but also more toxic. This toxicity complicates later operations. Sixty cases of ovarian cancer one analysed and the various complications related to chemotherapy described.
1820. [1 year's use of alizapride for the prevention and treatment of nausea and vomiting secondary to anticancer agents]. |