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1781. [Optic neuropathies].1783. [Disorders of oculopalpebral motility].1784. [Retinal diseases].1785. [Corneal, conjunctival and lacrimal changes (excluding dry eye)].1790. [Safety for the handling of cytostatic substances. Protective measures are useful].1791. [Recommendation concerning protective measures. Safety for the handling of cytostatic substances. The current situation--a "Swiss compromise"].1793. [Nephrotoxicity of anti-tumor agents].1794. [The effect of modification of the intracellular distribution of polyamines on the proliferation of hepatocytes treated with 2-methyl-9-hydroxyellipticine].
2-Methyl-9-hydroxyellipticine (MHE) added to tumoral hepatocyte cultures (400 ng MHE/ml medium) is responsible for a cytostatic effect. This decrease of cellular proliferation and of DNA synthesis is accompanied by an increase of intracellular free spermidine levels. We could not attribute this result to a deviation of this polyamine metabolism. These increased concentrations of free spermidine are connected to a decrease of the amount of nuclear bound polyamines, mainly joined with the RNA fraction. Thus, the cytostatic effect observed with this drug might be related to a decrease in the amount of spermidine connected to RNA; therefore, its intercalating effect is only indirectly responsible for the cellular proliferation decrease.
1795. [Drug-induced cochleovestibular pathology].1796. [Leukemias secondary to cytotoxic therapy. Study of 29 cases in Quebec and Montreal].
作者: A de Gramont.;M Bergeron.;Y Drolet.;P Leblond.;E Rioux.;L Desjardins.;M Gyger.;P d'Auteuil.;J M Delâge.
来源: Union Med Can. 1985年114卷4期334-7页 1797. [Medicines: antineoplastic chemotherapy].1798. [Vindesine in oral cancers].
Vindesine, a vinblastine derivative, was evaluated in 36 patients with malignant tumours of the buccal cavity previously untreated. Vindesine was used (1) pre-operatively, in short, weekly intravenous courses for 1 to 3 weeks and (2) prior to radiotherapy of inoperable tumours, in prolonged treatments, either by bolus i.v. injections with vein washing weekly or, in case of failure, by continuous i.v. infusion over 5 days. In the first group major responses were obtained in 22.2% of the cases. In the second group only 1 of 18 patients responded to weekly injections, whereas 3 out of 10 patients responded to continuous infusion (including one complete remission), showing that this mode of administration was more effective than bolus injections. Toxic reactions to the drug are discussed. Venous damage was the predominant complication of continuous infusion.
1799. [Fatal complication during treatment with elliptinium acetate].1800. [Apropos of the nephrotoxicity of antitumoral drug therapy].
作者: D Cordonnier.;J L Alix.;R Schaerer.;P Swiercz.;P Vialtel.;F Bayle.
来源: Presse Med. 1985年14卷1期51页 |