Darier and Ferrand dermatofibrosarcoma (DFS) is a rare skin tumor characterized by its local aggressiveness and a high risk of recurrences. Prognosis depends essentially on the quality of treatment. Complete response in Darier and Ferrand dermatofibrosarcoma with healthy margins, initially judged inoperable after 1 year of neoadjuvant imatinib-based treatment, has been rarely described in literature. We here report the case of a young female patient treated in the Department of Medical Oncology in FES for locally advanced DFS with complete response, in order to assess the role of imatinib and of targeted therapies in the treatment of DFS.

Osteochondroma is the most common benign bone tumor. It usually affects the metaphyses of the long bones, in particular around the knee and the proximal humerus. It very rarely affects the pubic symphysis, usually with an atypical symptomatology. We here report the case of a 35-year old man in whom osteochondroma in the pubic symphysis encroaching on the iliopubic branch was fortuitously discovered. Radiological examinations as well as macroscopic and histological examination confirmed the diagnosis and the absence of signs of malignancy.

colorectal cancer is a major public health problem. This study aims to analyze the epidemiological, nutritional, clinical and anatomopathological features of patients with colorectal cancer at the University Hospital in Casablanca.

Glomous tumors are rare and benign, generally affecting the fingers. Other localizations have nevertheless been described. We report the case of a patient who presented a supra-patellar glomous tumor provoking a pain-induced limp. Magnetic resonance imaging confirmed the diagnosis. The patient underwent complete surgical resection of the tumor followed by total resolution of the pain. Glomous tumors in an atypical localization may go unnoticed, with the risk of late or erroneous diagnosis. Symptoms are easily resolved with simple resection.

The central nervous system (CNS), through carcinomatous meningitis or solid brain metastases, is the most common site of recurrence in non-small cell lung cancers (NSCLC) with activating mutations. Our retrospective study describes the population of patients with CNS metastases of NSCLC harboring activating mutation with targeted therapy (EGFR, ALK, BRAF, HER2) in 4 French regional reference hospitals. 60 patients were analyzed. The proposed treatments were heterogeneous and included combinations of chemotherapy, targeted therapy and radiotherapy±associated with topical treatments. Median overall survival following CNS metastasis in these patients was 15.8 months for meningitis carcinoma and 26 months for brain metastases. In patients with brain metastases, the addition of targeted therapy treatment allows a significant improvement in median progression free survival from 5.9 months to 10.6 months (HR 0.48 CI95 [0.24 to 0.97] P=0.035). These patients seem therefore benefit from systemic therapy and particularly targeted therapy with better survival than usual.

To describe didactically the local, regional and systemic spread of choroidal melanoma.

Hidradenoma papilliferum (HP) is an adenomatous proliferation of mammary-like glands. These glands are located preferentially on the vaginal labia, the perineum and the anal skin. About ninety percent of HP occur on the vulva, with anal localization being much less common.

Eruptive melanocytic nevi (EMN) are a rare phenomenon characterized by simultaneous rapid onset of multiple nevi. The condition has been described in different contexts: immunosuppression, immunosuppressive drugs, targeted therapies, bullous diseases, and chemical melanocytic stimulation. We report 3 cases of EMN following anti-TNF alpha treatment.

Isolated mastocytoma is the most common form of mastocytosis in children. Prognosis is good, as in all other forms of mastocytosis in children, with possibility of spontaneous regression. Dermocorticoids can accelerate this regression, as it is the case for our patient.

Peripheral neuroectodermal tumors (PNET) of the kidney are extremely rare. They are often diagnosed at a late stage due to their nonspecific clinical presentation. Treatment of patients with metastases is based on palliative chemotherapy. We here report a case of PNET of the kidney with sudden onset of metastases to the lymph nodes and to the skin. The patient showed good clinical and radiological response and experienced progression-free survival at 6 years after polychemotherapy with vincristine, doxorubicin and cyclophosphamide.

Primary mediastinal non-Hodgkin's lymphoma(PMNHL) is a rare cancer. Exceptionally, it can be complicated by tracheœsophageal fistulas, directly connecting the esophagus and the trachea and secondary to esophageal tumor or chemotherapy (hence the interest of our case). We report the case of a 24-year old Moroccan female patient, treated for primary mediastinal large B cell NHL revealed by dyspnœa associated with dysphagia and alteration of general condition. The patient underwent chemotherapy but her health condition worsened after a second treatment due to the occurrence of recurrent pulmonary infections associated with cough during meals making swallowing impossible. Esogastroduodenal fibroscopy was performed which confirmed the diagnosis of tracheœsophageal fistula. Outcome was marked by patient's death despite endoscopic stent placement and a good response to chemotherapy. Early discovery of tracheœsophageal fistula in patients with PMNHL is essential because it enables the implementation of an appropriate treatment.

We report the case of a 56-year old female patient, with no particular past medical history, presenting at the Emergency Department with decreased visual acuity in the right eye occurred 2 weeks before. Ophthalmologic examination showed reduced visual acuity to perception of hand movements. Fundus examination showed serous retinal detachment associated with subretinal mass occupying almost the entirety of the vitreous cavity (A). B-mode scan was performed which objectified isoechoic choroidal mass (B) with vascularization on Doppler (C) without any excavation, measuring 18 mm along its longer axis associated with serous detachment of the retina, highly suggestive of ocular metastasis. General assessment was performed and, in particular, mammography which revealed the presence of a nodule in the right breast (stage 4 according to BI-RADS Classification). Thoraco abdominopelvic and brain CT scan performed during staging evaluation showed many brain, bone and liver metastases. The diagnosis of metastatic breast cancer was made and the patient was referred to the Department of Oncology for specialist treatment. Ocular metastases are the most common intraocular tumors. Breast tumors are the main cause of choroidal metastases, justifying comprehensive assessment to highlight these intraocular tumors.

Osteoblastoma is a rare benign bone tumor, accounting for 1% of all bone tumors. It mainly occurs in the long bones, more rarely in the jaws. Osteoblastoma of the jaws mainly involves the mandible while nasosinusal involvement is very rare. The diameter of the tumor can grow to 10 cm. On X-ray, the tumor may appear as a well or poorly defined clear lesion, usually scattered with mineral patches. Recurrence rate is very low after surgical resection as well as the risk of malignant transformation. We report the case of a 13-year old female patient presenting with nasal obstruction evolving over the last 3 months associated with episodes of epistaxis and left blurred vision. Clinical examination showed voluminous nasal concha with polyploid mucosa filling all the left nasal fossa with left axial exophthalmos. CT scan of the facial massif showed left frontoethmoidal expansive process measuring 50*47*36 mm, spontaneously hypodense, heterogeneous, non enhanced after injection of the Contrast materials, responsible for destruction of the ethmoidal labyrinth, swelling of the bony walls with mass effect on the ipsilateral orbit. The suspected diagnosis was frontoethmoidal mucocele. Hence, the decision to perform endonasal surgery. Whitish thick liquid was collected by the cranial portion of the middle nasal concha sugesting infected mucocele. Resection of the middle nasal concha was performed. The histological examination showed osteoblastoma of the middle nasal concha . Outcome was marked by regression of the exophthalmos with no recurrence during 1-year follow up period.

The objective of this study was to identify predictive factors of toxicity of docetaxel, platin, 5-fluorouracil (TPF) induction chemotherapy for locally advanced head and neck cancers.

The aim of this study was to assess the treatment outcome and toxicity for patients with locally advanced nasopharyngeal carcinoma treated with a complementary dose with proton.