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2462. [Intensive chemotherapy with bone marrow autograft in solid tumors].2463. [Digestive lymphosarcomas. Apropos of 30 cases].
作者: J L Amiel.;P Lasser.;P Rougier.;C Théodore.;G Chahine.;J P Droz.
来源: Sem Hop. 1983年59卷20期1513-7页
30 cases of digestive non-Hodgkin lymphomas are studied. Localization of the tumor was gastric in 14 cases, ileocoecal in 9 and in the small bowel in 7. Patients with gastric involvement are older (median 48 1/2 years) than those in the other groups (median 26 years). Management included maximal surgery followed by intensive chemotherapy with adriamycin, VM 26 and cyclophosphamide. This protocol gives excellent results: 85% lasting complete remissions with a median follow-up of 30 months and a maximal follow-up of 102 months. Failures occur only in the lymphoblastic cases which require a more intensive chemotherapy.
2464. [Primary chemotherapy in soft tissue sarcomas considered inoperable].
作者: J Rouëssé.;T Le Chevalier.;G Contesso.;D Sarrazin.;J L Amiel.;D Sevin.;P Carde.;J Génin.
来源: Sem Hop. 1983年59卷19期1441-4页
Fourteen adult patients with inoperable soft tissue sarcoma (with metastases in 4 cases) received chemotherapy as primary treatment. Nine cases were treated by CYVADIC (cyclophosphamide, vincristin, doxorubicin, DTIC) and five cases by DECAV (DTIC, cyclophosphamide, cis-platinum, doxorubicin, vindesine). An objective response was obtained in 7 cases (1 complete remission and 6 regressions greater than 50%) and stabilization in 4 cases. Seven patients became operable after 2 to 6 courses of chemotherapy and a complete resection could be performed in 6 cases. The duration of the response was 2 to 39 months. Toxicity with both combinations was acceptable. We conclude that chemotherapy can provide initial tumor reduction and permit subsequently less radical surgery.
2465. [The endocrine future after chemotherapy].2466. [Chronic lymphoid leukemia: study of a population of 196 patients].2467. [Adjuvant therapy of cancer of the breast: where are we now?].2468. [Chemotherapeutic approach to acute myeloid leukemia in adults].
作者: G L Biron.;Y Lapointe.;S Clément.;M Maheu.;S Laurin.;B Y Gosselin.
来源: Union Med Can. 1983年112卷5期412-4页 2469. [Autologous bone marrow grafts and solid tumors].2470. [Acute lymphoblastic leukemia in children: therapeutic aspects].2471. [Multiple myeloma with high tumoral mass. Treatment combining melphalan, cyclophosphamide, vincristine, CCNU and prednisone. 35 cases].
作者: B Brun.;M Kuentz.;N G Man.;F Feuilhade.;P Bierling.;J P Vernant.;J P Farcet.;C Cordonnier.;F Reyes.;B Dreyfus.;H Rochant.
来源: Presse Med. 1983年12卷19期1205-10页
The results of a combination chemotherapy trial (melphalan, CCNU, vincristine, cyclophosphamide) involving 28 patients with stage III (n = 21) or stage II (n = 7) multiple myeloma suggest a high response rate, with a mean 71% malignant cell destruction in 78.5% of the patients. A longer survival in responsive stage III patients as compared with patients treated with alkylating agents seems likely, but this can only be established by a randomized trial. Despite haematological side-effects, this combination therapy may be used in high risk patients, especially those resistant to a single alkylating agent and in whom the frequency, intensity and duration of responses appears to be the same as in previously untreated patients. In contrast, only one of the 7 patients treated for relapse after previous response to a single alkylating agent responded to the combination chemotherapy.
2472. [Non-surgical possibilities for the treatment of colorectal cancers].
The 5-year survival rate after radical excision of colorectal carcinoma has not increased for thirty years. The development of adjuvant therapy should bring marked progress, but none of the clinical trials so far conducted has shown an improvement which could mean a statistically significant difference in survival. Preoperative radiotherapy decreases the tumor volume and the incidence of invaded lymph nodes. The results of postoperative radiotherapy and chemotherapy are favourable, and the final answer with regard to their effectiveness can be expected in the near future.
2473. [Chemotherapy in the treatment of cancers of the digestive tract].2474. [Is it possible to predict the response of digestive cancers to chemotherapy?].2475. [Chemotherapy of solid tumors. The role of cisplatin in today's chemotherapy].2476. [The role of chemotherapy in the treatment of testicular cancer with the exception of seminomas].2477. [Monitoring anticancerous and antileukemic chemotherapy in children].
Chemotherapy is essential for the treatment of malignant diseases in childhood. Monitoring a child on chemotherapy includes: 1) looking for evidences of relapse or metastases; 2) if necessary, adjusting doses according to blood counts; 3) preventing and treating intercurrent infections, which are mostly viral, once the initial regimen is completed; 4) diagnosing and, if possible, treating, harmful side-effects, which cannot always be precluded; 5) helping both patient and family to live a normal life; in this respect, normal school attendance is of particular significance.
2478. [Late intensive chemotherapy with bone marrow autograft. Pilot study in small cell bronchial cancer].
Following three courses of induction chemotherapy, 23 patients with small cell carcinoma of the lung were treated with a late intensive regimen including autologous bone marrow infusion. Thirteen patients received high doses (2 or 3 times the induction chemotherapy dosage) of cisplatin, adriamycin and etoposide. One patient was probably cured, but renal and mucosal toxicity was observed. Three patients treated with adriamycin, etoposide and cyclophosphamide also developed severe mucositis. The seven remaining patients received high doses of cyclophosphamide (100 to 200 mg/kg) and etoposide (750 to 1000 mg/m2); responses were obtained with moderate toxicity. The long-term survival is not yet known. The usefulness of bone marrow infusion cannot be determined without further studies.
2479. [In vitro determination of the antitumor activity of chemotherapy].2480. [Treatment of cancers of the colon and rectum]. |