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2381. [Death during treatment with ellipticine].2382. [Chemotherapy via tunneled central venous catheter left in place between drug courses. Prospective study in 98 ambulatory patients].
Chemotherapy is normally given during several months and requires a good vascular access. Repeated injections of cytotoxic agents are harmful for peripheral veins. We report here a prospective study on 98 ambulatory patients provided with a tunneled central venous catheter left in situ between drug administration. The catheter is inserted either in the subclavian or the internal jugular vein. Between chemotherapy drugs injection, heparin is given once a week in the catheter. Among the several advantages reported with this technique: easiness of drug injection, comfort of patients, possibility of new insertions in an other site in case of occlusion and the low cost. This technique is a "routine" at the Institut Curie since 5 years. Advantages and side effects of this technique are compared with arterio-venous shunting or totally implantable devices used by other authors.
2383. [Epiphysiolysis of the hip following radiotherapy of pelvic tumors in early infancy. Apropos of 5 new cases].
Five personal cases of slipped capital femoral epiphysis in children submitted to pelvic radiotherapy and nineteen similar observations are reported. This complication appears around 6 years after radiotherapy; its frequency increases with high radiations doses and associated chemotherapy. Weakening of the epiphyseal plate is probably involved whatever radiations voltages. Surgical treatments should be confined to epiphysis fixation. As this complication can secondarily affect the other hip, preventive controlateral fixation must be discussed.
2384. [Therapeutic evolution of non-seminomatous cancers of the testicle].2385. [Intra-arterial chemotherapy of ORL tumors. 10 years' experience in the Antoine-Lacassagne Center].
作者: F Demard.;M Schneider.;J Vallicioni.;J Santini.;P Chauvel.
来源: Ann Otolaryngol Chir Cervicofac. 1985年102卷5期285-91页
One hundred and two patients with malpighian epithelioma of ORL origin were treated with intra-arterial chemotherapy (IAC) as initial therapy, followed by either surgery, radiotherapy or a combination of the two. Regression in tumor size of more than 50% was noted in 46% of cases, the introduction of cisplatin into the multiple system chemotherapy providing a response in 71% of the 42 patients treated in this way. A response to induction IAC is a factor of good prognosis as shown by the improvement in level of local and regional extensions and the probability rate of survival in responders. Technical and methodologic progress has made IAC a simple and effective procedure, and its place in the treatment of epitheliomas of head and neck should be established more precisely.
2386. [Infertility problems following radiotherapy and chemotherapy for testicular tumors].2387. [Preoperative chemotherapy of ovarian cancer in anesthesia and resuscitation].
Anti-mitotic chemotherapy has become more efficient but also more toxic. This toxicity complicates later operations. Sixty cases of ovarian cancer one analysed and the various complications related to chemotherapy described.
2388. [1 year's use of alizapride for the prevention and treatment of nausea and vomiting secondary to anticancer agents].2389. [Nephrotoxicity of mitomycin C (apropos of 25 case reports). Results of a multicenter survey organized by the Society of Nephrology].
We have studied 25 cases of hemolytic and uremic syndrome (H.U.S.) induced by mitomycin C, collected from 1976 to 1982 in 12 Nephrology Centers. Mitomycin C was administered in successive cures at a cumulative dose higher than 50 mg/m2. This H.U.S. is characterized by its slow and late occurrence, by extra-renal, mainly respiratory, manifestations that may reveal the disease, and finally by its pathological aspects. Mesangiolysis and endothelial or mesangial enlarged and atypical nuclei are observed in addition to the usual lesions of thrombotic micro-angiopathy. The prognosis was very poor in the first cases reported. It was better, however, in the patients studied more recently, because the cumulative dose was lower. In severe cases, plasma exchange might improve long-term prognosis. The disease might be due to a direct toxic effect of mitomycin C on the vascular endothelium.
2390. [Pulmonary changes caused by cytostatic drugs].
About 80 drugs are known to cause lung disease. Cytostatic agents are the most common cause of this type of iatrogenic disease. In addition to the "intercalating" type of cytostatic, other groups, especially the alkylating (busulfan) and the antimetabolites groups (methotrexate), have also been incriminated. Cytostatic drug-induced lung disease is a difficult diagnosis based on the results of clinical, radiological, respiratory function, histopathological and biological investigations. The results of bronchoalveolar lavage are vital, especially in lung disease due to a drug hypersensitivity reaction; the diagnosis of drug-induced pulmonary fibrosis due to a toxic mechanism is much more difficult and risky. Early diagnosis of these drug-induced lung diseases is obviously important.
2391. [Venous occlusive disease of the liver and autologous bone marrow transplantation. Preventive role for heparin?].
作者: J Y Cahn.;M Flesch.;E Plouvier.;P Hervé.;A Rozenbaum.
来源: Nouv Rev Fr Hematol (1978). 1985年27卷1期27-8页
The pathogenesis of veno-occlusive disease (VOD) of the liver remains unclear. In a retrospective study we reviewed 63 patients treated with high dose conditioning regimens followed by autologous bone marrow transplant. All patients were given low dose heparin (1 mg/kg). Only one patient developed VOD when heparin was stopped. We think that low dose heparin seems an interesting proposal for an randomized study to prevent VOD.
2392. [Current controversies regarding the treatment of primary osteosarcoma by chemotherapy].2393. [Treatment of acute myeloid leukemia with amsacrine and high-dose cytosine arabinoside: a phase II trial].
Ten patients with acute myeloid leukaemia on failure or relapse were treated by Amsacrine and high-dose (12 g/m2) Cytosine Arabinosyl (phase II trial). Four patients achieved complete remission, over six months in one instance. Hematologic toxicity was important but extra-hematologic toxicity was mild. These two drugs could be used as induction or reinforcement treatment in acute myeloid leukaemia.
2396. [Undifferentiated small cell bronchial cancer: role of the medical oncologist].2397. [Lipid peroxidation and free radicals. Role in cellular biology and pathology].
Membrane phospholipids attack by oxygen free radicals, i.e. lipidoperoxidation, occurs in normal cellular life. This free radicals attack is controlled by a protective system, both enzymatic (superoxide dismutase, catalase, glutahione peroxidase) and non enzymatic (vitamine E). Imbalance between attack and defense can explain many pathological events. In these events, the oxidation products of unsaturated fatty acids are of fundamental importance, in particular those derived from arachidonic acid (prostaglandins, prostacyclins, thromboxanes and leukotrienes).
2398. [Cancer chemotherapy and anesthesia].2399. [Chemotherapy by ambulatory continuous infusion using a portable pump: a feasibility trial].
作者: M Benahmed.;P Carde.;A Laplanche.;J Renaux.;J Rouesse.;M Spielmann.;H Sancho-Garnier.
来源: Bull Cancer. 1985年72卷1期30-6页
43 metastatic cancer patients received 190 portable infusors over 24 hours or more. This portable infusor is a disposable material made by Travenol which operates without outside energy. The drug in an elastomere balloon reservoir is injected about 24 hours at a rate of 2 ml/hour. We used various drugs: CDDP, bleomycin, 5 fluorouracil, aracytine, velbe, voltarene. The patients were under hospital observation and received their treatment without any incident due to the pump itself. The patients who had already been perfused with the usual technique greatly appreciated the comfort of this light portable device. Our next step will permit us to estimate the use of these infusors by patients at home.
2400. [Effect of interferons on the activity of human tumor degeneration factor (TDF)].
作者: J Imanishi.;A Tanaka.;H Matsuoka.;Y Kakui.;H Uemura.;T Imanishi.;H Nishino.
来源: C R Seances Soc Biol Fil. 1985年179卷4期549-53页
KB cells were cultivated in the well with tumor-degenerating factor (TDF) and the natural and recombinant interferons. TDF alone induced the degenerative changes of the KB cells and formed the cell-free area, but the interferons alone did not induce the changes and did not form the cell-free area. When KB cells were cultivated with TDF and natural interferons (HuIFN-alpha, -beta and -gamma), the cell-free area was enlarged. Particularly, HuIFN-gamma enhanced the TDF activity most strongly. The recombinant interferons (HuIFN-alpha, -beta and -gamma) also augmented in the same ways as the natural interferons.
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