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4. Lung Cancer in Nonsmoking Individuals: A Review.
Lung cancer in nonsmoking individuals (defined as people who have smoked fewer than 100 cigarettes in their lifetime) accounts for 15% to 20% of all lung cancer cases worldwide. In the US, the annual incidence of lung cancer in nonsmoking individuals is 14.4 to 20.8 per 100 000 person-years in females and 4.8 to 12.7 per 100 000 person-years in males.
11. Dalbavancin for Treatment of Staphylococcus aureus Bacteremia: The DOTS Randomized Clinical Trial.
作者: Nicholas A Turner.;Toshimitsu Hamasaki.;Sarah B Doernberg.;Thomas P Lodise.;Heather A King.;Varduhi Ghazaryan.;Sara E Cosgrove.;Timothy C Jenkins.;Catherine Liu.;Shrabani Sharma.;Smitha Zaharoff.;Lana Wahid.;Valerie J Renard.;Paul Cook.;Issam Raad.;Ray Hachem.;Anne-Marie Chaftari.;Matthew Sims.;Carmen DeMarco.;Loren G Miller.;Matthew W McCarthy.;Caryn G Morse.;Chris Lucasti.;Graeme N Forrest.;Kartikeya Cherabuddi.;Christopher Polk.;Tasaduq Fazili.;Mark E Rupp.;George R Thompson.;Kami Kim.;Luke Strnad.;Amanda E Schnee.;James A McKinnell.;Mayur Ramesh.;Fernanda P Silveira.;Todd P McCarty.;Todd C Lee.;Emily G McDonald.;Kristopher Paolino.;Katie Wiegand.;Alison Wall.;Todd Riccobene.;Rinal Patel.;Urania Rappo.;Scott Evans.;Henry F Chambers.;Vance G Fowler.;Thomas L Holland.; .
来源: JAMA. 2025年
Dalbavancin is a long-acting intravenous lipoglycopeptide that may be effective for treatment of complicated Staphylococcus aureus bacteremia without requiring long-term intravenous access.
17. Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.
作者: Timothy S Walsh.;Richard A Parker.;Leanne M Aitken.;Cathrine A McKenzie.;Lydia Emerson.;Julia Boyd.;Alix Macdonald.;Gayle Beveridge.;Annabel Giddings.;David Hope.;Sîan Irvine.;Sharon Tuck.;Nazir I Lone.;Kalliopi Kydonaki.;John Norrie.;David Brealey.;David Antcliffe.;Michael Reay.;Alan Williams.;Jeremy Bewley.;Benedict Creagh-Brown.;Daniel F McAuley.;Paul Dark.;Matt P Wise.;Anthony C Gordon.;Gavin D Perkins.;Michael C Reade.;Bronagh Blackwood.;Alasdair MacLullich.;Robert Glen.;Valerie J Page.;Christopher J Weir.; .
来源: JAMA. 2025年334卷1期32-45页
Whether α2-adrenergic receptor agonist-based sedation, compared with propofol-based sedation, reduces time to extubation in patients receiving mechanical ventilation in the intensive care unit (ICU) is uncertain.
18. A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease.
作者: .;Surya P Bhatt.;Ehsan Abadi.;Antonio Anzueto.;Sandeep Bodduluri.;Richard Casaburi.;Peter J Castaldi.;Michael H Cho.;Alejandro P Comellas.;Douglas J Conrad.;Jeffrey L Curtis.;Chandra Dass.;Dawn L DeMeo.;Mark T Dransfield.;Raul San José Estépar.;Eric L Flenaugh.;Marilyn G Foreman.;Spyridon Fortis.;Arnav Gupta.;MeiLan K Han.;Nicola A Hanania.;Craig P Hersh.;John E Hokanson.;Stephen M Humphries.;Miranda Kirby.;Ken M Kunisaki.;Pei Zhi Li.;David A Lynch.;Neil R MacIntyre.;Barry J Make.;David M Mannino.;Fernando J Martinez.;Charlene E McEvoy.;Bruce E Miller.;Matthew Moll.;Arie Nakhmani.;John D Newell.;Katherine A Pratte.;Elizabeth A Regan.;Joseph M Reinhardt.;Stephen I Rennard.;Harry B Rossiter.;Matthew J Strand.;Rajat Suri.;Emily S Wan.;Christine H Wendt.;Gloria E Westney.;Carla G Wilson.;Robert A Wise.;Kendra A Young.;Wan C Tan.;Edwin K Silverman.;James D Crapo.
来源: JAMA. 2025年333卷24期2164-2175页
Individuals at risk for chronic obstructive pulmonary disease (COPD) but without spirometric airflow obstruction can have respiratory symptoms and structural lung disease on chest computed tomography. Current guidelines recommend COPD diagnostic schemas that do not incorporate imaging abnormalities.
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