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1. Convolutional Neural Network Models Leverage Morphological Rather Than Temporal Features to Detect Myocardial Diseases From 12-Lead Electrocardiograms.
作者: Masamitsu Nakayama.;Ryuichiro Yagi.;Yoshinori Katsumata.;Masayuki Oki.;Rahul C Deo.;Calum A MacRae.;Shinichi Goto.
来源: Circ Arrhythm Electrophysiol. 2025年e014369页 2. Resolution of Systemic Inflammation in Patients With Recently Decompensated Heart Failure With Reduced Ejection Fraction With and Without Interleukin-1 Blockade by Anakinra.
作者: Benjamin W Van Tassell.;Michele Golino.;Justin M Canada.;Roshanak Markley.;Hayley Billingsley.;Marco Del Buono.;Azita Talasaz.;Georgia Thomas.;Juan Guido Chiabrando.;George Wohlford.;Virginia Dickson.;Dinesh Kadariya.;Juan Ignacio Damonte.;Ai-Chen Jane Ho.;Yub Raj Sedhai.;Emily Kontos.;Alessandra Vecchiè.;Joshua D West.;Giuliana Corna.;Horacio Medina de Chazal.;Sebastian Pinel.;Edoardo Bressi.;Andrew Barron.;Megan Dell.;James Mbualungu.;Francesco Moroni.;Jeremy Turlington.;Emily Federmann.;Cory Trankle.;Salvatore Carbone.;Ross Arena.;Antonio Abbate.
来源: Circ Heart Fail. 2025年e013546页
Decompensated heart failure with reduced ejection fraction (HFrEF) is associated with systemic inflammation that predicts unfavorable outcomes. We aimed to determine whether anakinra, an IL-1 (interleukin-1) blocker, favors inflammation resolution (CRP [C-reactive protein]) and improves peak oxygen consumption (VO2) in patients with recently decompensated HFrEF.
3. Real-Time Biventricular Pressure-Volume Loops During Percutaneous Pulmonary Valve Implantation in Patients With RVOT Dysfunction.
作者: Heiner Latus.;Verena Schindler.;Julie Cleuziou.;Markus Khalil.;Christian Jux.;Christian Meierhofer.;Daniel Tanase.;Andreas Eicken.;Peter Ewert.;Stanimir Georgiev.
来源: Circ Heart Fail. 2025年e013235页
In patients with right ventricular (RV) outflow tract stenosis and pulmonary regurgitation (PR), percutaneous pulmonary valve implantation (PPVI) aims to preserve RV and left ventricular (LV) integrity and function. Our study aimed to assess acute changes in biventricular intrinsic myocardial function occurring with PPVI.
5. Letter by Hang et al Regarding Article, "An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress".6. Response by Balligand and Michel to Letter Regarding Article, "An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress".7. A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank.
作者: Russell Stewart.;Brandon D Lowery.;Eric Farber-Eger.;Yuko Wada.;Dan M Roden.;Quinn S Wells.;Giovanni Davogustto.
来源: Circulation. 2025年152卷25期1806-1808页 12. Athlete's Heart or Heart at Risk? Cardiac Remodeling and Exercise-Induced Ventricular Arrhythmias in Elite Athletes.
作者: Giuseppe Di Gioia.;Maria Rosaria Squeo.;Armando Ferrera.;Francesco Raffaele Spera.;Viviana Maestrini.;Sara Monosilio.;Federica Mango.;Giulia Paoletti.;Andrea Serdoz.;Marco Bernardi.;Antonio Pelliccia.
来源: Circ Arrhythm Electrophysiol. 2025年e014143页
Ventricular ectopic beats (VEBs) are frequently observed in athletes, but their clinical significance remains debated. We aimed to assess the prevalence, pattern of exercise-induced VEBs, and their association with exercise-induced cardiac remodeling (EICR) in elite athletes.
13. Percutaneous Patent Foramen Ovale Closure During ProtekDuo Support and Transcatheter Tricuspid Repair After Left Ventricular Assist Device Implantation: While the Right Ventricle Gives Up, Cardiologists Don't.
作者: Marco Tomasino.;Sofía Vila-Sanjuán.;Eduard Ródenas-Alesina.;Toni Soriano-Colomé.;Laia Milà.;Javier Solsona-Caravaca.;Gerard Martí-Aguasca.;Ignacio Ferreira-González.;Aitor Uribarri.
来源: Circ Heart Fail. 2025年e013354页 15. 2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
作者: Michelle Gurvitz.;Eric V Krieger.;Stephanie Fuller.;Leslie L Davis.;Michelle M Kittleson.;Jamil A Aboulhosn.;Elisa A Bradley.;Jonathan Buber.;Curt J Daniels.;Konstantinos Dimopoulos.;Alexander Egbe.;Tracy R Geoffrion.;Anitha John.;Paul Khairy.;Yuli Y Kim.;Jacqueline Kreutzer.;Matthew J Lewis.;Jonathan N Menachem.;Jeremy P Moore.;Kathryn A Osteen.;Puja B Parikh.;Arwa Saidi.;Katherine B Salciccioli.;Rachel L Schunder.;Anne Marie Valente.;Rachel M Wald.
来源: Circulation. 2025年
The "2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease" provides recommendations to guide clinicians on the evaluation and treatment of adult patients with congenital heart disease. It incorporates new evidence to replace the "2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease."
17. Bradycardia in Athletes: Prevalence, Mechanisms, and Risks.
作者: Paolo D'Ambrosio.;Jarne De Paepe.;Luke W Spencer.;Monique Ohanian.;Kristel Janssens.;Amy M Mitchell.;M Darragh Flannery.;Youri Bekhuis.;Rik Pauwels.;Boris Delpire.;Christophe Dausin.;Stephanie J Rowe.;Tim Van Puyvelde.;Paul Young.;Magdalena Soka.;Renee Johnson.;Chenglong Yu.;Gwilym M Morris.;Tomas Robyns.;Paul Lacaze.;Eleni Giannoulatou.;Peter M Kistler.;Jonathan M Kalman.;Hein Heidbuchel.;Rik Willems.;Guido Claessen.;Diane Fatkin.;André La Gerche.; .
来源: Circulation. 2025年
Sinus bradycardia is a well-recognized physiological adaptation in endurance athletes, primarily attributed to sinus node remodeling or increased vagal modulation. Although genetic influences on resting heart rate (HR) have been observed, the genetic contribution to athletic bradycardia has not been elucidated.
18. Macrophage-Specific E3 Ubiquitin Ligase TRIM31 Reduces Atherosclerotic Plaque Formation by Targeting LOX-1.
作者: Jie Zhang.;Liwen Yu.;Wei Yang.;Lei Cao.;Xiaohong Wang.;Chunyu Kao.;Zijing Li.;Ruiqing Ren.;Wenqian Qi.;Lijuan Lyu.;Wenjing Xiong.;Wenhai Sui.;Xiao Wu.;Na Li.;Bingjie Liu.;Shasha Wang.;Peili Bu.;Yun Zhang.;Chengjiang Gao.;Cheng Zhang.;Meng Zhang.
来源: Circulation. 2025年
Atherosclerosis is a chronic inflammatory disease marked by lipid accumulation and immune cell infiltration in arterial walls. Macrophages contribute by internalizing oxidized low-density lipoprotein, forming foam cells, and driving inflammation. The ubiquitin-proteasome system regulates immune and inflammatory responses in atherosclerosis. This study investigated the protective role of TRIM31 (tripartite motif-containing 31), an E3 ubiquitin ligase, in macrophage lipid metabolism and inflammation through selective regulation of LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1).
19. IMPROVE-DiCE, a 2-Part, Open-Label, Phase 2a Trial Evaluating the Safety and Effectiveness of Ninerafaxstat in Patients With Cardiometabolic Syndromes.
作者: Moritz J Hundertmark.;Sarah M Birkhoelzer.;Clara Portwood.;Adrienne G Siu.;Violet Matthews.;Andrew J Lewis.;James Grist.;Ferenc Mózes.;John A Henry.;Jai Patel.;Paul Chamberlin.;Rizwan Sarwar.;Arash Yavari.;Hakim-Moulay Dehbi.;Prashant Rao.;Xu Shi.;Shuning Zheng.;Jeremy M Robbins.;Robert E Gerszten.;Michael P Frenneaux.;Ladislav Valkovič.;Jack J J J Miller.;Stefan Neubauer.;Damian J Tyler.;Oliver J Rider.
来源: Circulation. 2025年
We report IMPROVE-DiCE (Improve Diabetic Cardiac Energetics), a 2-part open-label, phase 2a trial evaluating the safety and effectiveness of ninerafaxstat, a novel therapeutic designed to enhance cardiac energetics. Between May and September 2021, part 1 enrolled patients with type 2 diabetes and obesity without heart failure with preserved ejection fraction (HFpEF). Between January 2023 and June 2024, part 2 enrolled patients with type 2 diabetes, obesity, and HFpEF.
20. Endothelial Transcription Factor EB Protects Against Doxorubicin-Induced Endothelial Toxicity and Cardiac Dysfunction.
作者: Wa Du.;Madison Ringer.;Wei Huang.;Darshini Desai.;Golam Iftakhar Khandakar.;Luis Tron Esqueda.;Chenran Wang.;Jun-Lin Guan.;Richard C Becker.;Sakthivel Sadayappan.;Guo-Chang Fan.;Yigang Wang.;Yanbo Fan.
来源: Circulation. 2025年
Doxorubicin (DOX), an effective chemotherapeutic drug for various cancers, has been demonstrated to induce cardiovascular toxicity in cancer survivors. Endothelial cell (EC) dysfunction is recognized to play a critical role in the onset and severity of cardiotoxicity associated with DOX. TFEB (transcription factor EB), a master regulator of autophagy and lysosome biogenesis, regulates cardiovascular homeostasis. In the present study, we aimed to test whether endothelial TFEB protects against EC damage and alleviates cardiac dysfunction induced by DOX treatment.
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