Plentiful studies have reported that preoperative gamma-glutamyltransferase (GGT) had a strong relationship with the prognosis of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE). Nevertheless, due to the small sample size and contradictory conclusions, the predictive function remains indefinite. To investigate the relationship between pretreatment GGT value and clinical outcomes in HCC patients undergoing TACE, a meta-analysis including 10 articles was constructed.

With the development of comfortable medical care, the application of intravenous anesthesia in painless gastroscopy is becoming increasingly widespread. However, anesthetic drugs may have adverse effects on postoperative cognitive function, and the risk of postoperative cognitive dysfunction (POCD) is particularly worthy of attention in the elderly population. Our aim is to evaluate the effect of intravenous anesthesia on postoperative cognitive function (POCF) in patients undergoing painless gastroscopy, with a focus on identifying potential risks of POCD and guiding clinical anesthesia practices.

The object of this study was to explore the risk factors for incomplete excision of colorectal polyps (CP) through a systematic review and meta-analysis.

This study aimed to systematically evaluate the effects of Enhanced Recovery After Surgery (ERAS) nursing protocols on patients undergoing laparoscopic colectomy.

Endoscopic retrograde cholangiopancreatography (ERCP) is a widely utilized procedure for diagnosing and treating biliary and pancreatic disorders. However, it carries a risk of post-ERCP pancreatitis (PEP). N-Acetylcysteine (NAC) has been proposed as a potential prophylactic agent due to its antioxidant properties, yet its efficacy remains debated. This systematic review and meta-analysis aimed to evaluate the effectiveness of NAC in preventing PEP in patients undergoing ERCP.

The number of risk prediction models for lymph node metastasis in early gastric cancer is increasing, but the quality and applicability of these models in clinical practice and future research remain unknown.

We compared the efficacy of four treatment strategies for chronic hepatitis B (CHB): tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), tenofovir amibufenamide (TMF), and TDF-to-TAF switch strategies strategy. We conducted a network meta-analysis to provide evidence-based clinical guidance.

We performed an updated systematic review and network meta-analysis to inform the 2025 American Gastroenterological Association Clinical Guidelines on the management of moderate-to-severe Crohn's disease (CD).

The most prevalent complication of endoscopic retrograde cholangiopancreatography (ERCP) is post-ERCP acute pancreatitis (PEP). Both hydration and rectal non-steroidal anti-inflammatory drugs (NSAIDs) can effectively prevent PEP; however, there is currently no consensus on whether combination therapy is more effective than either intervention alone.

ATG16L1 rs2241880 (T300A), a single-nucleotide variant, plays a controversial role in the development of Crohn's disease (CD).

Gastric cancer remains a leading cause of cancer-related morbidity and mortality worldwide, with surgery being central to treatment. However, postoperative malnutrition is common and significantly impairs recovery. Early oral feeding (EOF) has been proposed as a strategy to promote gastrointestinal recovery and reduce complications, but its clinical effectiveness following gastrectomy remains uncertain.

The prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) among children and adolescents with overweight and/or obesity is rising globally, reflecting increasing obesity rates and metabolic syndrome. This study aims to provide a comprehensive global estimate of MAFLD prevalence in this population.

To assess the efficacy of glutamine in preventing diarrhea associated with chemotherapy or chemoradiotherapy in colorectal cancer.

Refractory ulcerative colitis (UC), characterized by persistent disease activity despite optimized medical therapy, poses a significant therapeutic challenge. Fecal microbiota transplantation (FMT) has shown promise in inducing remission in active ulcerative colitis (UC) by restoring gut microbial balance; however, its efficacy in refractory cases remains unclear. This systematic review and meta-analysis aimed to evaluate the effectiveness and safety of FMT in achieving clinical and endoscopic remission in patients with refractory UC, based on evidence from randomized controlled trials (RCTs).

To compare the effects of single-day and multi-day low-residue diets on bowel preparation quality and patient tolerance of colonoscopy.

Severe acute pancreatitis (SAP) lacks a definitive treatment option. Although ulinastatin has demonstrated anti-inflammatory and organ-preserving properties, its role in SAP remains unclear due to divergent findings. Hence, we evaluated the efficacy and role of ulinastatin in patients with SAP.

Capsule endoscopy (CE) is a primary tool for small bowel visualization, but its diagnostic yield can be limited by prolonged transit times and finite battery life. Various interventions, including prokinetics, purgatives, and magnetic steering, are used to optimize CE performance. This systematic review and meta-analysis compare the effectiveness of these strategies in improving transit times and completion rates.

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are extensively used in the management of type 2 diabetes mellitus (T2DM) and obesity. While these medications offer glycemic control and cardiovascular benefits, the risks have increased because of their potential impact on cancer risk, particularly colorectal cancer (CRC). This meta-analysis aimed to evaluate the association between GLP-1 RAs and CRC risk in patients receiving GLP-1 RAs.

Autoimmune hepatitis (AIH) is a chronic progressive inflammatory liver disease of immune-mediated origin, which causes long-term liver inflammation and damage. Traditionally, treatment includes azathioprine (AZA) combined with steroids, but recent studies have highlighted mycophenolate mofetil (MMF) as a potential alternative, particularly for patients who do not respond well to AZA.

This study aims to evaluate the association between IDO index and the prognosis of colorectal cancer (CRC). We searched databases such as PubMed, to collect relevant English studies on the association between IDO level and the prognosis of CRC published before October 10, 2024. This meta-analysis included 11 studies involving 2068 patients. The results showed that IDO levels were not significantly correlated with OS in CRC patients (HR0.85, 95%CI 0.54-1.33, P = 0.488), but elevated IDO was associated with reduced disease-free survival (DFS) in CRC patients (HR 0.61, 95%CI 0.38-0.99, P = 0.044).Elevated IDO was significantly associated with the incidence of liver metastasis (HR 4.66, 95%CI 1.72-12.64, P = 0.003) and lymphatic infiltration (HR 2.75, 95%CI 1.52-4.97, P < 0.001) in CRC patients. In conclusion, high expression of IDO is significantly associated with DFS, liver metastasis and lymphatic infiltration in CRC patients, and may serve as a biomarker and therapeutic target for DFS, liver metastasis, and lymphatic metastasis in CRC.