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1691. Pediatric Persistent Inflammation, Immunosuppression, and Catabolism Syndrome Prevalence in Sepsis-Related Mortalities: A 23-Year Institutional History.
作者: Stephanie G Patterson.;Celia K Lamb.;Wu Gong.;Jackson Resser.;Christopher J Lindsell.;Sara L Van Driest.;Ryan J Stark.
来源: Chest. 2023年164卷5期1204-1215页
Delayed mortality in sepsis often is linked to a lack of resolution in the inflammatory cascade termed persistent inflammation, immunosuppression, and catabolism syndrome (PICS). Limited research exists on PICS in pediatric patients with sepsis.
1692. Does OSA Increase Risk for Cancer?: A Large Historical Sleep Clinic Cohort Study.
作者: Ross J Marriott.;Bhajan Singh.;Nigel McArdle.;Ellie Darcey.;Stuart King.;Daniela Bond-Smith.;Ayesha Reynor.;William Noffsinger.;Kim Ward.;Sutapa Mukherjee.;David R Hillman.;Gemma Cadby.
来源: Chest. 2023年164卷4期1042-1056页
The relationship between OSA and cancer is unclear.
1693. Emulating Target Trials Comparing Early and Delayed Intubation Strategies.
作者: Kerollos Nashat Wanis.;Arin L Madenci.;Sicheng Hao.;Mira Moukheiber.;Lama Moukheiber.;Dana Moukheiber.;Sulaiman Moukheiber.;Jessica G Young.;Leo Anthony Celi.
来源: Chest. 2023年164卷4期885-891页
Whether intubation should be initiated early in the clinical course of critically ill patients remains a matter of debate. Results from prior observational studies are difficult to interpret because of avoidable flaws including immortal time bias, inappropriate eligibility criteria, and unrealistic treatment strategies.
1694. Lung Transplantation for Pulmonary Arterial Hypertension.
Even though patients with pulmonary arterial hypertension have multiple therapeutic options, the disease can be refractory despite appropriate management. In patients with end-stage pulmonary arterial hypertension, lung transplantation has the potential both to extend survival and improve health-related quality of life. Pulmonary arterial hypertension is the only major diagnostic indication for transplantation that is not a parenchymal pulmonary process, and thus the care of these patients is unique.
1695. The Effects of Exercise Training in Patients With Persistent Dyspnea Following Pulmonary Embolism: A Randomized Controlled Trial.
作者: Øyvind Jervan.;Stacey Haukeland-Parker.;Jostein Gleditsch.;Mazdak Tavoly.;Frederikus A Klok.;Kjetil Steine.;Hege Hølmo Johannessen.;Martijn A Spruit.;Dan Atar.;René Holst.;Anders Erik Astrup Dahm.;Per Anton Sirnes.;Knut Stavem.;Waleed Ghanima.
来源: Chest. 2023年164卷4期981-991页
Persistent dyspnea, functional limitations, and reduced quality of life (QoL) are common following pulmonary embolism (PE). Rehabilitation is a potential treatment option, but the scientific evidence is limited.
1696. Implementation of Lung Cancer Screening in Primary Care and Pulmonary Clinics: Pragmatic Clinical Trial of Electronic Health Record-Integrated Everyday Shared Decision-Making Tool and Clinician-Facing Prompts.
作者: Polina V Kukhareva.;Haojia Li.;Tanner J Caverly.;Guilherme Del Fiol.;Angela Fagerlin.;Jorie M Butler.;Rachel Hess.;Yue Zhang.;Teresa Taft.;Michael C Flynn.;Chakravarthy Reddy.;Douglas K Martin.;Isaac A Warner.;Salvador Rodriguez-Loya.;Phillip B Warner.;Kensaku Kawamoto.
来源: Chest. 2023年164卷5期1325-1338页
Although low-dose CT (LDCT) scan imaging lung cancer screening (LCS) can reduce lung cancer mortality, it remains underused. Shared decision-making (SDM) is recommended to assess the balance of benefits and harms for each patient.
1697. Lower vs Higher Fluid Volumes in Adult Patients With Sepsis: An Updated Systematic Review With Meta-Analysis and Trial Sequential Analysis.
作者: Praleene Sivapalan.;Karen L Ellekjaer.;Marie K Jessen.;Tine S Meyhoff.;Maria Cronhjort.;Peter B Hjortrup.;Jørn Wetterslev.;Anders Granholm.;Morten H Møller.;Anders Perner.
来源: Chest. 2023年164卷4期892-912页
IV fluids are recommended for adults with sepsis. However, the optimal strategy for IV fluid management in sepsis is unknown, and clinical equipoise exists.
1698. High-Definition Videobronchoscopy for the Diagnosis of Airway Involvement in Sarcoidosis: The Enhance Sarcoidosis Multicenter Study.
作者: Vanina Livi.;Ilya Sivokozov.;Jouke T Annema.;Piero Candoli.;Igor Vasilev.;Tess Kramer.;Marco Ferrari.;Karan Madan.;David Fielding.;Septimiu Murgu.;Alessandra Cancellieri.;Lyudmila A Semyonova.;Mariangela Puci.;Giovanni Sotgiu.;Rocco Trisolini.
来源: Chest. 2023年164卷5期1243-1252页
The ability of high-definition (HD) videobronchoscopy to detect airway involvement in sarcoidosis has not been evaluated previously.
1699. Procalcitonin-Guided Antibiotic Prescription in Patients With COVID-19: A Multicenter Observational Cohort Study.
作者: Lisa M Hessels.;Esther Speksnijder.;Nienke Paternotte.;Astrid van Huisstede.;Willemien Thijs.;Margot Scheer.;Mariëlle van der Steen-Dieperink.;Lieve Knarren.;Joop P van Den Bergh.;Kristien Winckers.;Ronald Henry.;Suat Simsek.;Wim G Boersma.; .
来源: Chest. 2023年164卷3期596-605页
Despite the low rate of bacterial coinfection, antibiotics are very commonly prescribed in hospitalized patients with COVID-19.
1700. Cell-Free DNA Fragmentomes in the Diagnostic Evaluation of Patients With Symptoms Suggestive of Lung Cancer.
作者: Alessandro I C Leal.;Dimitrios Mathios.;Debbie Jakubowski.;Jakob S Johansen.;Anna Lau.;Tony Wu.;Stephen Cristiano.;Jamie E Medina.;Jillian Phallen.;Daniel C Bruhm.;Jacob Carey.;Nicholas C Dracopoli.;Stig E Bojesen.;Robert B Scharpf.;Victor E Velculescu.;Anil Vachani.;Peter B Bach.
来源: Chest. 2023年164卷4期1019-1027页
The diagnostic workup of individuals suspected of having lung cancer can be complex and protracted because conventional symptoms of lung cancer have low specificity and sensitivity.
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