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1493. Spironolactone vs Amiloride for Resistant Hypertension: A Randomized Clinical Trial.
作者: Chan Joo Lee.;Sang-Hyun Ihm.;Dong-Ho Shin.;Jin-Ok Jeong.;Ju Han Kim.;Kyeong-Hyeon Chun.;JiWung Ryu.;Hae-Young Lee.;Seonghoon Choi.;Eun Mi Lee.;Jung Hyun Choi.;Kwang-Il Kim.;Jinho Shin.;Wook Bum Pyun.;Dae-Hee Kim.;Sungha Park.;Bryan Williams.
来源: JAMA. 2025年333卷23期2073-2082页
Amiloride has been proposed as an alternative to spironolactone for treating resistant hypertension. However, no randomized clinical trials have compared the efficacy of spironolactone and amiloride in patients with resistant hypertension.
1497. Screening for Syphilis Infection During Pregnancy: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
作者: Gary N Asher.;Meera Viswanathan.;Afua Takyi.;Jennifer Cook Middleton.;Claire Baker.;Leila C Kahwati.
来源: JAMA. 2025年333卷22期2015-2017页 1498. Screening for Syphilis Infection During Pregnancy: US Preventive Services Task Force Reaffirmation Recommendation Statement.
作者: .;Michael Silverstein.;John B Wong.;Esa M Davis.;David Chelmow.;Tumaini Rucker Coker.;Alicia Fernandez.;Ericka Gibson.;Carlos Roberto Jaén.;Marie Krousel-Wood.;Sei Lee.;Wanda K Nicholson.;Goutham Rao.;John M Ruiz.;James Stevermer.;Joel Tsevat.;Sandra Millon Underwood.;Sarah Wiehe.
来源: JAMA. 2025年333卷22期2006-2012页
Untreated syphilis infection during pregnancy can be passed to the fetus, causing congenital syphilis. Congenital syphilis is associated with premature birth, low birth weight, stillbirth, neonatal death, and significant abnormalities in the infant such as deformed bones, anemia, enlarged liver and spleen, jaundice, brain and nerve problems (eg, permanent vision or hearing loss), and meningitis. In 2023, there were 3882 cases of congenital syphilis in the US, including 279 congenital syphilis-related stillbirths and neonatal/infant deaths, the highest number reported in more than 30 years.
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