123. Postpartum Persistence of Ebola Virus in Breast Milk.
作者: Meris Matondo-Kuamfumu.;Martin Faye.;Grace Kavugho-Hangi.;Daniel Mukadi-Bamuleka.;François Edidi-Atani.;Servet Kimbonza.;Eddy Kinganda-Lusamaki.;Adrienne Amuri-Aziza.;Junior Bulabula-Penge.;Amadou Alpha Sall.;Jean-Jacques Muyembe-Tamfum.;Steve Ahuka-Mundeke.;Ousmane Faye.;Placide Mbala-Kingebeni.
来源: N Engl J Med. 2026年394卷11期1138-1139页 124. Helicobacter pylori Screen-and-Treat Programs for Gastric Cancer Prevention - IARC Working Group Report.
作者: Jin Young Park.;Yi-Chia Lee.;Paul Moayyedi.;Iris Lansdorp-Vogelaar.;M Constanza Camargo.;Bojan Tepeš.;Christian C Abnet.;Il Ju Choi.;Gary Clifford.;Mario Dinis-Ribeiro.;Markus Gerhard.;Javier P Gisbert.;Karen J Goodman.;Joo Ha Hwang.;Manami Inoue.;Violet Kayamba.;Marcis Leja.;Wai Keung Leung.;Wen-Qing Li.;Peter Malfertheiner.;Zorana Maravic.;Tamara Matysiak-Budnik.;Melissa McLeod.;Francis Megraud.;Eileen Morgan.;Duco T Mülder.;Julie Parsonnet.;Pempa Pempa.;Guru Prasad Dhakal.;Arnoldo Riquelme.;Peter Sasieni.;Stella Smith.;Janet Takens.;Andrea Teng.;David Forman.
来源: N Engl J Med. 2026年394卷11期1131-1137页 132. Polymyalgia Rheumatica.
Polymyalgia rheumatica is an inflammatory condition that affects persons older than 50 years of age and is characterized by pain in both shoulders with or without hip or neck pain (or both) and with pronounced morning stiffness. The condition is typically diagnosed on the basis of these hallmark symptoms along with elevated inflammation markers (erythrocyte sedimentation rate and C-reactive protein level) and the ruling out of other conditions including giant-cell arteritis. Glucocorticoids are the primary treatment, which provide rapid symptom relief. The initial dose, usually 12.5 to 25 mg of prednisone equivalent daily, is gradually reduced, ideally over 12 months or less, although the disease course varies and polymyalgia rheumatica may persist for a longer duration. Relapses are common and sometimes warrant the use of interleukin-6 receptor inhibitors or methotrexate to minimize glucocorticoid exposure.
133. Romiplostim versus Placebo for Chemotherapy-Induced Thrombocytopenia.
作者: Hanny Al-Samkari.;César Muñoz.;Çağlayan Geredeli.;Ippokratis Korantzis.;Beatriz González Astorga.;Cagatay Arslan.;Johnny Francisco Cordeiro Camargo.;Florian Scotté.;Giuliano Borges.;Kejia Wang.;Melissa Eisen.;David J Kuter.;Gerald A Soff.
来源: N Engl J Med. 2026年394卷11期1061-1073页
Chemotherapy-induced thrombocytopenia (CIT) is a common complication of chemotherapy that is associated with bleeding, reduced relative dose intensity, and potentially worse outcomes. No widely available therapies are approved for CIT.
134. Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism.
作者: Lana A Castellucci.;Vivien M Chen.;Michael J Kovacs.;Alejandro Lazo-Langner.;Peter Greenstreet.;Susan Kahn.;Benoit Côté.;Sam Schulman.;Kerstin de Wit.;James Douketis.;Deepa Suryanarayan.;Tony Wan.;Erik Yeo.;Genevieve Le Templier.;Huyen A Tran.;Abbey Willcox.;Helen J Crowther.;Ritam Prasad.;Sudeep Shivakumar.;Etimbuk Umana.;Fionnuala Ni Ainle.;Tobias Tritschler.;Stefano Barco.;Jean-Philippe Galanaud.;Marc Blondon.;Lisa Baumann Kreuziger.;Susan Solymoss.;Clive Kearon.;Erin Thomas.;Tim Ramsay.;Gregoire Le Gal.;Marc Rodger.; .
来源: N Engl J Med. 2026年394卷11期1051-1060页
Apixaban and rivaroxaban are the oral anticoagulants most frequently used to treat acute venous thromboembolism. However, uncertainty remains about the difference in bleeding risk between the two medications.
136. Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis.
作者: Steven D Nathan.;Peter Smith.;Chunqin Deng.;Maria De Salvo.;Wim Wuyts.;Juana Pavie-Gallegos.;Jin Woo Song.;Mordechai R Kramer.;Christopher S King.;John A Mackintosh.;Daniel Chambers.;Georgina Viviana Miranda.;Natalie Breytenbach.;Leigh Peterson.;Heidi Bell.;Kevin R Flaherty.;Juergen Behr.;Vincent Cottin.; .
来源: N Engl J Med. 2026年
Preclinical data indicate that inhaled treprostinil may be useful for the treatment of idiopathic pulmonary fibrosis (IPF) through an antifibrotic mechanism, a premise that is supported by clinical observation.
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