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1042. Progressive Dyspnea in a Woman With Tracheal Stenosis and Rheumatoid Arthritis.
作者: Eugene Shostak.;Rutvi Amin.;Genna Braverman.;Sharon Steinberger.;Cynthia Magro.
来源: Chest. 2024年166卷1期e15-e20页
An 82-year-old woman with a remote tracheostomy due to vocal cord paralysis and long-standing erosive, seropositive rheumatoid arthritis (RA) well controlled with methotrexate sought treatment at the ED with 1 month of dyspnea, chest tightness, and cough productive of blood-tinged sputum. She had been treated unsuccessfully as an outpatient with multiple courses of antibiotics. She did not smoke or drink alcohol and had no recent travel outside the country. Given concern for airway compromise, she was admitted to the hospital.
1044. Group 5 Pulmonary Hypertension Associated With T-Cell Large Granular Lymphocytic Leukemia: Hemodynamics and Treatment.
作者: Daniel J Strick.;Harrison W Farber.;Nicholas S Hill.;Ioana R Preston.;Natasha M Pradhan.;Bipin Malla.
来源: Chest. 2024年166卷1期e1-e3页
Group 5 pulmonary hypertension (PH) encompasses diverse diseases, with a few cases linking it to T-cell large granular lymphocytic (LGL) leukemia. We report a case of a 76-year-old woman, diagnosed with LGL leukemia and concomitant PH, treated with oral triple pulmonary arterial hypertension (PAH) therapy. She initially presented with dyspnea on exertion; evaluation revealed severe precapillary PH. Implementing cyclophosphamide for leukemia along with tadalafil and macitentan for PH led to sustained symptomatic and hemodynamic improvement for over 3 years. At that time, deterioration in PH prompted the addition of selexipag, resulting in sustained clinical improvement for an additional 5 years. This case exemplifies the potential for sustained benefits of PAH therapy in leukemia-associated PH and highlights the need for continued research on the mechanistic relationship between LGL leukemia and PH, with the hope of identifying new management strategies.
1058. Eosinopenia as Predictor of Disease Severity in Patients With Community-Acquired Pneumonia: An Observational Study.
作者: Barbara Christine Weckler.;Hendrik Pott.;Alan Race.;Nattika Jugkaeo.;Kapil Karki.;Stephan Ringshandl.;Christian Seidemann.;Ines Schöndorf.;Harald Renz.;Sebastian Fähndrich.;Anna Lena Jung.;Wilhelm Bertrams.;Adeline Makoudjou.;Daniela Zöller.;Susetta Finotto.;Stefanie Schild.;Susanne A Seuchter.;Gernot Rohde.;Frederik Trinkmann.;Timm Greulich.;Claus Franz Vogelmeier.;Bernd Schmeck.
来源: Chest. 2024年166卷6期1329-1333页 1059. Comparison of Early and Late Norepinephrine Administration in Patients With Septic Shock: A Systematic Review and Meta-Analysis.
作者: Chiwon Ahn.;Gina Yu.;Tae Gun Shin.;Youngsuk Cho.;Sunghoon Park.;Gee Young Suh.
来源: Chest. 2024年166卷6期1417-1430页
Vasopressor administration at an appropriate time is crucial, but the optimal timing remains controversial.
1060. Association Between Spontaneous Breathing Trial Methods and Reintubation in Adult Critically Ill Patients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
作者: Mariachiara Ippolito.;Salvatore Sardo.;Vincenzo Francesco Tripodi.;Nicola Latronico.;Elena Bignami.;Antonino Giarratano.;Andrea Cortegiani.
来源: Chest. 2024年166卷5期1020-1034页
Reintubation is associated with higher risk of mortality. There is no clear evidence on the best spontaneous breathing trial (SBT) method to reduce the risk of reintubation.
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