921. Examining how resistance training affects bone strength in older adults with rheumatic diseases: a systematic review.
Rheumatic diseases significantly impact global healthcare through disability, lost productivity, and reduced quality of life, making them an important focus for researchers. As physiological changes associated with aging decrease bone mineral density, rheumatic diseases further elevate fracture risk in older adults. Resistance training has been shown to counteract age-related declines through increases in muscle, strength, and bone mineral density, demonstrating its potential for mitigating bone mineral density loss. This systematic review examines the effectiveness of resistance training interventions in maintaining or improving bone mineral density in older adults with rheumatic diseases, an issue of relevance given impaired skeletal integrity linked to these diseases.
922. Diagnostic and therapeutic insights from a cohort of chronic recurrent multifocal osteomyelitis (CRMO) patients.
作者: Kosar Asna Ashari.;Mahdieh Mousavi.;Fatemeh Tahghighi Sharabian.;Raheleh Assari.;Seyyed Reza Raeeskarami.;Vahid Ziaee.
来源: BMC Rheumatol. 2025年9卷1期70页
Chronic recurrent multifocal osteomyelitis (CRMO) is a sporadic form of autoinflammatory bone disorders (ABDs) presenting with sterile chronic and/or recurrent and multiple sites of bone involvement. We aimed to describe our 10-year cohort of CRMO patients and analyze the characteristics and treatment approaches.
923. Risk factors and predictive model for mild cognitive impairment in elderly patients with rheumatoid arthritis.
作者: Jun Yan.;Hua Guo.;Lin-Xin Zhang.;Pei Chen.;Yong-Ku Du.;Juan Li.;Ya-Ya Gao.;Nan Ye.
来源: BMC Rheumatol. 2025年9卷1期69页
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by joint destruction and systemic inflammation, both of which significantly impair patients' quality of life. Mild cognitive impairment (MCI), a reversible precursor to dementia, is increasingly prevalent among elderly RA patients. Early identification of MCI in this population allows for timely interventions to slow cognitive decline.
924. Integration of clinical and serological biomarkers in a nomogram for predicting interstitial lung disease in idiopathic inflammatory myopathies.
作者: Zhixia Wang.;Jingyun Zhang.;Jin Li.;Xiaona Mao.;Yangyang Li.;Dekun Wang.;Wenpeng Ge.;Jingzhan Li.;Changhua Liang.;Zhiqiang Zhang.
来源: BMC Rheumatol. 2025年9卷1期73页
Idiopathic inflammatory myopathies (IIM) are a diverse group of autoimmune diseases characterized primarily by muscle weakness and systemic involvement, which can include interstitial lung disease (ILD). ILD is a serious complication in IIM, significantly affecting patient prognosis and quality of life. Early identification of IIM patients at risk for developing ILD is crucial for timely intervention and personalized treatment, yet the factors contributing to this risk remain inadequately defined.
925. Disease knowledge and quality of life among rheumatoid arthritis patients: a cross-sectional study.
作者: Lara Albiss.;Suhaib Muflih.;Bushra Hijazi.;Osama Y Alshogran.;Walid Al-Qerem.;Manar Abu Khurmah.;Ahmad Al-Azayzih.;Hani Shatnawi.;Yazan Shakatira.
来源: BMC Rheumatol. 2025年9卷1期77页
This study aimed to predict the knowledge of disease, quality of life, and related factors among rheumatoid arthritis patients.
926. Unraveling cerebrovascular involvement in EGPA through digital subtraction angiography: case presentation and systematic literature review.
作者: Viren Vasandani.;Sean O'Leary.;Ronak Gandhi.;Elena Diller.;Giri Movva.;John Broussard.;Vijaya Murthy.
来源: BMC Rheumatol. 2025年9卷1期80页
Eosinophilic granulomatosis with polyangiitis (EGPA) involves systemic inflammation of small to medium vessels, with central nervous system (CNS) involvement being rare. While CT (computed tomography) and MRI (magnetic resonance imaging) are standard for diagnosing CNS involvement, digital subtraction angiography (DSA) is infrequently used. We present a unique EGPA case with CNS involvement and review EGPA CNS vascular variations.
927. Association between life's essential 8 and risk of rheumatoid arthritis: a cross-sectional study.
To investigate the relationship between Life's Essential 8 (LE8) and its individual constituents and the risk of rheumatoid arthritis (RA).
928. Sociodemographic and economic barriers to initial specialist care for patients with rheumatoid arthritis: a scoping review.
作者: Jack Ainsworth.;Marita Bolic.;Ibrahim Ismail.;Zinat Mohammadpour.;John Wood.
来源: BMC Rheumatol. 2025年9卷1期76页
Rheumatoid arthritis is an autoimmune disease that can cause joint destruction, pain, loss of function, and reduced quality of life. Recent advancements in treatment have made it possible to control the impacts of this once-debilitating disease through early intervention. While numerous studies have examined barriers to rheumatoid arthritis care, no review has synthesized sociodemographic and economic factors across high-, upper middle-, and lower middle-income countries. This gap in the literature highlights the need for a comprehensive review that informs global health interventions. This review explores sociodemographic and economic barriers to initial specialist care for patients with rheumatoid arthritis.
930. The therapeutic potential for JAK inhibitors for immune-related adverse events from checkpoint inhibitors: a review of the literature.
作者: Deepak Nagra.;Kaiyang Song.;Joy Odia.;Chris Wincup.;Arti Mahto.;Chamith Rosa.;Ganesh Kasavkar.;Maryam A Adas.;Zijing Yang.;Mark D Russell.;Katie Bechman.;Tim Blake.;Siwalik Banerjee.;Nicola Gullick.;James B Galloway.
来源: Rheumatology (Oxford). 2025年64卷11期5641-5646页
The role of JAK inhibitors in immune-mediated adverse events was not included in the EULAR 2021 guidance on the management of rheumatic immune-related adverse events (irAE) from checkpoint inhibitors or the society of immunotherapy of cancer guidelines on this topic. We aim to describe the role of JAK inhibitors for the management of immune-mediated adverse events with a review of case reports.
931. Potential protective role of high Mediterranean diet adherence for systemic lupus erythematosus: mediation by liver and kidney function biomarkers in the UK Biobank cohort.
作者: Zi-Cheng Song.;Jia-Jia Hu.;Xue-Ying Xia.;Shu-Ting Liu.;Jie Zhang.;Hong-Fei Cao.;Dong-Qing Ye.;Wei Zhao.
来源: Rheumatology (Oxford). 2025年64卷11期5767-5775页
Despite advances in the treatment of SLE, the complexity and high mortality of the disease drive the need to explore primary prevention strategies. The Mediterranean diet (MD) has shown benefits for various diseases, but its role in SLE remains controversial, lacking evidence from large prospective studies. This study aims to investigate the association between MD and SLE risk and to analyse the potential mediating role of MD-related biomarkers.
932. Mapping MSU crystal deposition within MTP joints in tophaceous gout: a dual-energy CT study.
作者: Chamaya De Silva.;Cèsar Díaz-Torné.;Greg Gamble.;Anne Horne.;Anthony Doyle.;Lisa K Stamp.;Nicola Dalbeth.
来源: Rheumatology (Oxford). 2025年64卷11期5761-5766页
In gout, MSU crystal deposition occurs preferentially within certain joints, particularly the first MTP joint. The aim of this study was to map the distribution of MSU crystals within the MTP joints in people with tophaceous gout.
933. Distribution of white matter hyperintensity in SSc patients: a monocenter, cross-sectional magnetic resonance imaging study.
作者: Shihan Xu.;Xinyu Tong.;Huilin He.;Mengtao Li.;Zuoxiang He.;Xihai Zhao.;Dong Xu.
来源: Rheumatology (Oxford). 2025年64卷11期5733-5740页
Systemic Sclerosis (SSc) is a systemic autoimmunity White matter hyperintensities (WMH) are typical indicators of cerebral small vessel disease, classified into periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH). Our study aims to investigate the quantitative characteristics and distribution patterns of WMH between SSc patients, healthy population and between different SSc subtypes using magnetic resonance (MR) imaging. Whether cognitive dysfunction and anxiety/depression are associated with white matter alterations in the SSc were also explored.
935. Microscopic polyangiitis presenting with retinal frosted branch angiitis.
作者: Tajamul H Mir.;Reem Javeed.;Bushra Jabeen.;Alok Sharma.;Afroz Khan.;Junaid S Wani.;Murtaza R Pala.;Rabia N Ahmed.;Ahtesham Ahmed.;Sibgatullah Chesti.;M Omar Parvaiz.
来源: Lancet Rheumatol. 2025年 937. Loneliness and social isolation among middle-aged and older adults with SLE: a single centre cross-sectional study.
作者: Sarah B Lieber.;Yvonne Shea.;Sarah P Gottesman.;Amaya Smole.;Neha G Nagpal.;Julia Nguyen.;Ashley Chung.;Dongmei Sun.;Iris Navarro-Millán.;M Carrington Reid.;Lisa A Mandl.
来源: Rheumatology (Oxford). 2025年64卷11期5635-5640页
Loneliness and social isolation are associated with adverse health outcomes in older adults and may affect those with SLE disproportionately. We sought to understand the impact of loneliness, social isolation and social support on health-related quality of life (HRQoL) in middle-aged and older adults with SLE.
938. Distinct cytokine and cytokine receptor expression patterns characterize different forms of myositis.
作者: Raphael A Kirou.;Iago Pinal-Fernandez.;Maria Casal-Dominguez.;Katherine Pak.;Corinna Preusse.;Dilbe Dari.;Stefania Del Orso.;Faiza Naz.;Shamima Islam.;Gustavo Gutierrez-Cruz.;Elie Naddaf.;Teerin Liewluck.;Werner Stenzel.;Albert Selva-O'Callaghan.;Jose C Milisenda.;Andrew L Mammen.
来源: Rheumatology (Oxford). 2025年64卷11期5751-5760页
Myositis is a heterogeneous family of inflammatory myopathies. We sought to define the differential expression of cytokines, cytokine receptors and immune checkpoint genes in muscle biopsies from patients with different forms of myositis in order to characterize patterns of inflammation in each.
939. Associations of healthy lifestyle and genetic susceptibility with risks of osteoarthritis: a prospective cohort study.
作者: Shibo Chen.;Yujie Zhang.;Tianxiang Fan.;Muhui Zeng.;Qian Yang.;Hao Yang.;Xiaofeng Fang.;Xingzhong Jin.;Peihua Cao.;Zhiqiang Wang.;Yan Zhang.;David J Hunter.;Yuan Zhou.;Changhai Ding.;Zhaohua Zhu.; .
来源: Rheumatology (Oxford). 2025年64卷11期5673-5680页
To detect the associations of a healthy lifestyle and genetic susceptibility with incident OA in the UK Biobank study.
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