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921. Prognostic Relevance of Tricuspid Annular Plane Systolic Excursion to Systolic Pulmonary Arterial Pressure Ratio and Its Association With Exercise Hemodynamics in Patients With Normal or Mildly Elevated Resting Pulmonary Arterial Pressure.
作者: Teresa John.;Alexander Avian.;Nikolaus John.;Antonia Eger.;Vasile Foris.;Katarina Zeder.;Horst Olschewski.;Manuel Richter.;Khodr Tello.;Gabor Kovacs.;Philipp Douschan.
来源: Chest. 2025年167卷2期573-584页
Echocardiographic tricuspid annular plane systolic excursion (TAPSE) to systolic pulmonary arterial pressure (sPAP) ratio is a noninvasive surrogate for right ventricle (RV)-pulmonary arterial (PA) coupling. It has been related to outcome in patients with moderate to severe pulmonary hypertension (PH).
922. Red Blood Cell Transfusion in Critically Ill Adults: An American College of Chest Physicians Clinical Practice Guideline.
作者: Angel O Coz Yataco.;Israa Soghier.;Paul C Hébert.;Emilie Belley-Cote.;Margaret Disselkamp.;David Flynn.;Karin Halvorson.;Jonathan M Iaccarino.;Wendy Lim.;Christina C Lindenmeyer.;Peter J Miller.;Kevin O'Neil.;Kathryn M Pendleton.;Lisa Vande Vusse.;Daniel R Ouellette.
来源: Chest. 2025年167卷2期477-489页
Blood products frequently are administered to critically ill patients. Considering recent trials and practice variability, a comprehensive review of current evidence was deemed essential to offer pertinent guidance to critical care practitioners. This American College of Chest Physicians (CHEST) guidelines panel examined the literature on RBC transfusions among critically ill patients overall and specific subgroups, including patients with gastrointestinal bleeding, acute coronary syndrome (ACS), cardiac surgery, isolated troponin elevation, and septic shock, to provide evidence-based recommendations.
923. Mortality and Health Outcomes Among Patients With Sarcoidosis Treated With Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers.
作者: Joseph Fares.;Omar El Fadel.;Joy Zhao.;Michael Li.;Jianxin Sun.;Jesse Roman.;Giorgos Loizidis.;Ross Summer.
来源: Chest. 2025年167卷3期772-780页
Sarcoidosis is a multisystem inflammatory disease in which management and outcomes can vary widely. The renin-angiotensin-aldosterone system (RAAS) has been implicated in its pathogenesis, yet the impact of RAAS modulators on health outcomes in sarcoidosis remains poorly understood.
924. Lower or Higher Oxygenation Targets in Patients With COVID-19 in the ICU: A Secondary Bayesian Analysis of the Handling Oxygenation Targets in COVID-19 Trial.
作者: Frederik Mølgaard Nielsen.;Thomas Lass Klitgaard.;Anders Granholm.;Theis Lange.;Anders Perner.;Olav Lilleholt Schjørring.;Bodil Steen Rasmussen.
来源: Chest. 2025年167卷3期757-767页
In the Handling Oxygenation Targets in COVID-19 (HOT-COVID) trial, a Pao2 target of 60 mm Hg compared with 90 mm Hg resulted in more days alive without life support at 90 days in adults in the ICU with COVID-19 and hypoxemia. The trial was stopped after enrolling 726 of 780 planned patients because of slow recruitment. Herein, we present the preplanned Bayesian analysis of the HOT-COVID trial.
925. Risk of Pulmonary Diseases in Osteogenesis Imperfecta in Denmark: A Register-Based Cohort Study.
作者: Jane Dahl Andersen.;Marie Louise Lyster.;Mette Kathrine Holst.;Daniel Pilsgaard Henriksen.;Anders Christensen.;Christian B Laursen.;Antonella Forlino.;Lars Folkestad.
来源: Chest. 2025年167卷3期806-817页
Osteogenesis imperfecta (OI) is a rare hereditary disease mainly resulting in reduced or altered collagen type I. Collagen type I is a major constituent of the respiratory system, and normal collagen type I is vital for pulmonary tissue function.
926. Physiologic Comparison of Airway Pressure Release Ventilation and Low Tidal Volume Ventilation in ARDS: A Randomized Controlled Trial.
作者: Xiaojing Zou.;Hongling Zhang.;Yongran Wu.;Ruiting Li.;Xuehui Gao.;Azhen Wang.;Xin Zhao.;Xiaobo Yang.;Huaqing Shu.;Hong Qi.;Zhaohui Fu.;Shiying Yuan.;Yilei Ma.;Le Yang.;You Shang.;Zhanqi Zhao.
来源: Chest. 2025年167卷2期453-465页
The physiologic effects of different ventilation strategies on patients with ARDS need to be better understood.
927. The Association Between Air Pollution and Lung Function in Sarcoidosis and Implications for Health Disparities.
作者: Ali M Mustafa.;Kevin J Psoter.;Kirsten Koehler.;Nancy Lin.;Meredith McCormack.;Edward Chen.;Robert A Wise.;Michelle Sharp.
来源: Chest. 2025年167卷2期507-517页
Sarcoidosis is a granulomatous disease with varying courses of disease progression. Environmental exposures are thought to be contributors to disease onset. Exposure to air pollutants such as fine particulate matter of 2.5 μm diameter or smaller (PM2.5) and nitrogen dioxide (NO2) have been identified as contributors to health disparities in lung diseases; little is known about these environmental exposures' associations with disease outcomes in sarcoidosis.
928. Implications of Global Lung Function Initiative Spirometry Reference Equations in Northeast Asian Patients With COPD.
作者: Joon Young Choi.;Chang-Hoon Lee.;Hyonsoo Joo.;Yun Su Sim.;Jaechun Lee.;Hyun Lee.;Kwang Ha Yoo.;Seoung Ju Park.;Ju Ock Na.;Yet Hong Khor.
来源: Chest. 2025年167卷2期414-424页
Accurate spirometry interpretation is critical in the diagnosis and management of COPD. With increasing efforts for a unified approach by the Global Lung Function Initiative (GLI), this study evaluated the application of race-specific 2012 GLI and race-neutral 2022 GLI reference equations compared with Choi's reference equations, which are derived and widely used in South Korea, for spirometry interpretation in Northeast Asian patients with COPD.
934. A 70-Year-Old Man With an Encapsulated Mediastinal Fluid Collection.
A 70-year-old man was diagnosed with mid-thoracic esophageal squamous cell carcinoma (distance from incisors, 27-30 cm) because of progressive dysphagia and underwent thoracic laparoscopic esophagectomy at a local hospital. He was transferred from the ICU 4 days after surgery; however, a large amount of purulent fluid exuded from the neck incision after oral drinking, which was consistent with cervical anastomotic leakage. Later, the patient experienced difficulty breathing and expelling sputum; he was then transferred back to the ICU for treatment. A CT scan showed massive fluid collection in the mediastinum and left pleural cavity. Thoracentesis yielded yellowish fluid, and the patient's general condition gradually improved after placement of a closed chest drainage system. The patient's cervical anastomotic fistula persisted and did not heal, and he was subsequently transferred to our medical center with the closed chest drainage system left in place.
935. A 76-Year-Old-Man With Dyspnea and Abnormal Oximetry Run.
作者: Veronica Williams.;Franck F Rahaghi.;Ian R Drexler.;Lewjain Sakr.
来源: Chest. 2024年166卷3期e83-e87页
A 76-year-old male Vietnam veteran with a medical history of OSA on CPAP, mild COPD, Parsonage-Turner syndrome (a rare neurologic syndrome manifesting with shoulder and arm pain), hypertension, gastroesophageal reflux, hiatal hernia, and prior endocarditis presented with 1 year duration progressive exertional dyspnea with minimal activity by referral from an outside pulmonologist. The patient reported possible exposure to Agent Orange during his service but was otherwise without significant occupational or environmental exposures. His exercise tolerance was well-maintained up until the last 12 months. Aside from marginal cigarette use, he denied any recreational drug use or any anorectic use. The patient provided records from a recent right heart catheterization (RHC) months earlier for review.
936. Syncope in an Otherwise Healthy 74-Year-Old Woman.
作者: Zein Kattih.;Mateus Fernandes.;Miguel A Alvarez Villela.;Stephen Machnicki.;Erica Altschul.
来源: Chest. 2024年166卷3期e79-e82页
A 74-year-old woman with a history of hypertension and peripheral artery disease and a reported diagnosis of sarcoidosis presents for an episode of syncope and shortness of breath. She had a history of sarcoidosis diagnosed on chest radiography that showed lymphadenopathy. There were no associated symptoms, and she was not previously treated for sarcoidosis. She previously smoked and had quit smoking 9 years earlier.
937. Chylothorax in a Young Woman With Crohn Disease.
Chylothorax, which accounts for 1% to 3% of pleural effusions, typically results from either surgery (traumatic) or underlying malignancy (nontraumatic). Less common causes of nontraumatic chylothorax are numerous and include congenital lymphatic abnormalities, connective tissue diseases, cirrhosis, and infection, among others.1 We describe what appears to be the first reported case of chylothorax caused by chylous ascites in Crohn disease. This case highlights the importance of using diagnostic evidence to link new symptoms to preexisting diseases whenever possible, as well as the systemic nature of Crohn disease.
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