62. In active lupus nephritis, adding obinutuzumab to standard therapy increased complete renal response rates at 76 wk.
GIM/FP/GP: [Formula: see text] Nephrology: [Formula: see text] Rheumatology: [Formula: see text].
63. Embracing Compassion for People Facing Lung Cancer-the American Cancer Society National Lung Cancer Roundtable.
作者: Jamie L Studts.;Lisa Carter-Bawa.;Jill Feldman.;Joan H Schiller.;Elizabeth Scharnetzki.;James Pantelas.;Eugene Manley.;Timothy J Williamson.;M Patricia Rivera.;Lori C Sakoda.;Douglas Wood.;Ella A Kazerooni.;Lauren S Rosenthal.;Robert A Smith.;Drew Moghanaki.
来源: Ann Intern Med. 2025年 64. In VTE at high risk for recurrence, reduced- vs. full-dose DOACs did not differ for symptomatic recurrence but reduced bleeding at 37 mo.
GIM/FP/GP: [Formula: see text] Hematology: [Formula: see text].
65. In AF with stable CAD, an OAC alone does not increase ischemic events and reduces major bleeding vs. OAC + SAPT at a mean 22 mo.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
66. In ACS with DES, de-escalating DAPT to ticagrelor alone vs. standard DAPT reduces major bleeding without increasing ischemic events.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
67. In type 2 diabetes with CKD and additional CV risk factors, sotagliflozin reduced total MACE vs. placebo at a median 14 mo.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Endocrinology: [Formula: see text] Nephrology: [Formula: see text].
69. SCCM made 4 conditional recommendations for managing symptoms in adults admitted to the ICU.
作者: Brian Osorio.;Irene Vargas.;Saraschandra Vallabhajosyula.; .
来源: Ann Intern Med. 2025年178卷6期JC62页
GIM/FP/GP: [Formula: see text] Critical Care: [Formula: see text].
70. In untreated Graves disease, adding methotrexate to methimazole increased euthyroidism-related treatment discontinuation at 18 mo.
GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].
71. In survivors of ICH with AF, DOACs reduced incident ischemic stroke and increased recurrent ICH at a median 1.4 y.
Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Neurology: [Formula: see text] Hematology: [Formula: see text].
72. Link between compliance with, or implementation of, the SEP-1 sepsis bundle and mortality is mixed (low-level evidence).
GIM/FP/GP: [Formula: see text] Infectious Disease: [Formula: see text] Critical Care: [Formula: see text].
77. Statin Therapy as Primary Prevention for Persons With HIV: A Synopsis of Recommendations From the U.S. Department of Health and Human Services Antiretroviral Treatment Guidelines Panel.
作者: Craig Beavers.;Alice K Pau.;David Glidden.;Emily Hyle.;Safia Kuriakose.;Seth S Martin.;Grace McComsey.;Melanie Thompson.;Salim Virani.;Jason V Baker.
来源: Ann Intern Med. 2025年178卷6期847-857页
REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) showed benefits of pitavastatin as preventive therapy for atherosclerotic cardiovascular disease (ASCVD) in people with HIV (PWH). In February 2024, the U.S. Department of Health and Human Services Panel for the Use of Antiretroviral Agents in Adults and Adolescents with HIV (ARV Guidelines Panel) developed statin therapy recommendations for PWH. These recommendations were issued in collaboration with representatives from the American College of Cardiology (ACC), the American Heart Association (AHA), and the HIV Medicine Association (HIVMA). This synopsis summarizes the development process, the recommendations, and how they supplement the AHA/ACC/multisociety cholesterol guidelines and outlines gaps in primary prevention of ASCVD for PWH.
80. Associations Between Unconditional Cash Transfers and Postpartum Outcomes in the United States : A Systematic Review.
作者: Sahar A Choudhry.;G Saradjha Brédy.;Cyerra Cruise.;Qai Hinds.;Margaret A McConnell.;Sumit Agarwal.;David B Flynn.;Mara E Murray Horwitz.
来源: Ann Intern Med. 2025年
Unconditional cash transfers (UCTs) through social programs or direct cash transfers (DCTs) may address drivers of pregnancy-related morbidity and mortality.
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