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684. Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk: The TOP Randomized Clinical Trial.
作者: Panos Kougias.;Sherene E Sharath.;Min Zhan.;Jeffrey L Carson.;L Erin Norman.;Zhibao Mi.;Rupsi Pal.;Hasan Dosluoglu.;J Gregory Modrall.;George A Sarosi.;Peter Nelson.;Shipra Arya.;Alexandra Scrymgeour.;Jade Ollison.;Lawrence A Calais.;Vijay Nambi.;L Parker Gregg.;Shuaib M Abdullah.;Shirling Tsai.;Natasha Becker.;Justin C Choi.;Louisa Chiu.;Salvatore Scali.;Neal R Barshes.;Samir Awad.;Mohammed Moursi.;Matthew C Koopmann.;Mitchell Sally.;Daniel Ihnat.;Archana Ramaswamy.;Warren Gasper.;Edith Tzeng.;Mark A Wilson.;Gale Tang.;Grant Huang.;Kousick Biswas.; .
来源: JAMA. 2025年334卷24期2197-2207页
Postoperative red blood cell transfusion guidelines recommend transfusion for hemoglobin levels less than 7 g/dL. However, the safety of this strategy in patients at high risk of cardiac events undergoing major operations remains unclear.
685. Metformin to Improve Walking Performance in Lower Extremity Peripheral Artery Disease: The PERMET Randomized Clinical Trial.
作者: Mary M McDermott.;Kathryn J Domanchuk.;Lu Tian.;Lihui Zhao.;Dongxue Zhang.;Lydia Bazzano.;Scott Berceli.;Michael H Criqui.;Luigi Ferrucci.;Jack M Guralnik.;Christiaan Leeuwenburgh.;Karen J Ho.;Ahmed Ismaeel.;Melina R Kibbe.;Claudia Korcarz.;Kate Kosmac.;Donald Lloyd-Jones.;Charlotte A Peterson.;James H Stein.;Robert Sufit.;John Wilkins.;Tamar S Polonsky.
来源: JAMA. 2026年335卷5期407-415页
Lower extremity peripheral artery disease (PAD) is a disabling cardiovascular condition that impairs walking ability. Few effective therapies improve walking performance in people with PAD. Metformin is a widely available and inexpensive therapy for type 2 diabetes with pleiotropic effects that include activating AMP-activated protein kinase, reducing oxidative stress, and stimulating endothelial nitric oxide synthase (eNOS).
687. SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria: A Meta-Analysis.
作者: Brendon L Neuen.;Robert A Fletcher.;Stefan D Anker.;Deepak L Bhatt.;Javed Butler.;David Z I Cherney.;Kieran F Docherty.;Silvio E Inzucchi.;Meg J Jardine.;Kenneth W Mahaffey.;Finnian R McCausland.;Darren K McGuire.;John J V McMurray.;Bruce Neal.;Milton Packer.;Siddharth M Patel.;Vlado Perkovic.;Marc S Sabatine.;Rebecca J Sardell.;Scott D Solomon.;Muthiah Vaduganathan.;Christoph Wanner.;David C Wheeler.;Faiez Zannad.;Richard Haynes.;Natalie Staplin.;William G Herrington.;Hiddo J L Heerspink.; .
来源: JAMA. 2026年335卷3期233-244页
Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce chronic kidney disease (CKD) progression in individuals with type 2 diabetes, CKD, or heart failure. However, their effects in those with stage 4 CKD or little to no albuminuria remain uncertain.
689. Discordance in Creatinine- and Cystatin C-Based eGFR and Clinical Outcomes: A Meta-Analysis.
作者: Michelle M Estrella.;Shoshana H Ballew.;Yingying Sang.;Morgan E Grams.;Josef Coresh.;Aditya Surapaneni.;Natalia Alencar de Pinho.;Johan Ärnlöv.;Hermann Brenner.;Juan-Jesus Carrero.;Teresa K Chen.;Debbie L Cohen.;Mary Cushman.;Ron T Gansevoort.;Shih-Jen Hwang.;Lesley A Inker.;Joachim H Ix.;Keiko Kabasawa.;Tsuneo Konta.;Jennifer S Lees.;Kevan R Polkinghorne.;Michael G Shlipak.;Robin W M Vernooij.;David C Wheeler.;Ashok Kumar Yadav.;Andrew S Levey.;Kai-Uwe Eckardt.; .
来源: JAMA. 2025年334卷21期1915-1926页
Estimated glomerular filtration rates (eGFRs) can differ according to whether creatinine or cystatin C is used for the eGFR calculation, but the prevalence and importance of these differences remain unclear.
691. Effects of Sodium Glucose Cotransporter 2 Inhibitors by Diabetes Status and Level of Albuminuria: A Meta-Analysis.
作者: Natalie Staplin.;Alistair J Roddick.;Brendon L Neuen.;Stefan D Anker.;Deepak L Bhatt.;Javed Butler.;David Z Cherney.;Kieran F Docherty.;Robert A Fletcher.;Silvio E Inzucchi.;Meg Jardine.;Kenneth W Mahaffey.;Darren K McGuire.;John J V McMurray.;Bruce Neal.;Milton Packer.;Siddharth M Patel.;Vlado Perkovic.;Marc S Sabatine.;Scott Solomon.;Muthiah Vaduganathan.;Christoph Wanner.;David C Wheeler.;Faiez Zannad.;Richard Haynes.;Hiddo J L Heerspink.;William G Herrington.; .
来源: JAMA. 2026年335卷3期220-232页
There is uncertainty about the effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors in participants with chronic kidney disease, with guidelines offering different strengths of recommendation based on diabetes status and urine albumin to creatinine ratio (UACR).
693. A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial.
作者: Kathleen D Liu.;Edward D Siew.;Delphine S Tuot.;Anitha Vijayan.;Gonzalo Matzumura Umemoto.;Bethany C Birkelo.;Benjamin J Lee.;Y Diana Kwong.;Ian E McCoy.;Kevin Delucchi.;Hanjing Zhuo.;Chi-Yuan Hsu.
来源: JAMA. 2026年335卷4期326-335页
For patients with dialysis-requiring acute kidney injury, persistent need for dialysis is associated with increased morbidity and mortality, high health care use, and poor quality of life.
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