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644. Comparative trends in pancreatic cancer burden and risk factors in the USA and China (1990-2021): insights from GBD analysis.
作者: Chengzhou Pa.;Shijun Shen.;Shuxian Song.;Kuan Li.;Gang Chen.
来源: BMC Gastroenterol. 2025年25卷1期879页
Pancreatic cancer (PC) remains a lethal malignancy with rising global incidence, yet disparities in risk profiles between high-income and transitioning economies are poorly characterized. This study compared PC burden trends and attributable risk factors in China and the USA (1990–2021), offering evidence for region-specific prevention.
645. Predictive model for early fluid requirement in severe acute pancreatitis.
作者: Ayijiang Jiamaliding.;Gaolei Sun.;Junhong Wang.;Minjie Duan.;Qingbian Ma.
来源: BMC Gastroenterol. 2025年25卷1期841页
Severe acute pancreatitis (SAP) involves significant fluid loss, necessitating precise fluid therapy. However, standardized protocols are lacking. This study aimed to develop a machine learning-based prediction model for fluid requirement in SAP patients.
646. Efficacy of GLP-1 receptor agonists on obesity and metabolic profile in patients with inflammatory bowel disease: a systematic review and meta-analysis.
作者: Fatemeh Ojaghi Shirmard.;Seyed Morteza Pourfaraji.;Mahyaar Omouri-Kharashtomi.;Arash Amani.
来源: BMC Gastroenterol. 2025年25卷1期878页
Previous studies have shown an increase in obesity prevalence in the inflammatory bowel disease (IBD) population. The popularity of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) has increased in recent years due to their effectiveness in weight management. In this comprehensive review, we evaluate the efficacy of GLP-1 RAs in the management of obesity in patients with IBD.
647. AGA Living Clinical Practice Guideline on the Pharmacologic Management of Moderate-to-Severe Crohn's Disease.
作者: Frank I Scott.;Ashwin N Ananthakrishnan.;Benjamin Click.;Manasi Agrawal.;Gaurav Syal.;John P Haydek.;Yuhong Yuan.;Michael D Kappelman.;James D Lewis.;Siddharth Singh.
来源: Gastroenterology. 2025年169卷7期1397-1448页
This American Gastroenterological Association (AGA) living guideline is intended to support practitioners in the pharmacologic management of moderate-to-severely active Crohn's disease (CD).
648. The global, regional, and national burden of appendicitis in the elderly population aged 60 years and above from 1990 to 2021: trends, current status, and future predictions based on the 2021 global burden of disease data: a systematic analysis.
作者: Yuhang Yang.;Yuan He.;Yan Li.;Yuyuan Hu.;Wei Zhang.;Jinghan Jia.;Dawei Ye.;Jinxi Wang.
来源: BMC Gastroenterol. 2025年25卷1期827页
Currently, there is a lack of attention and research on appendicitis in the elderly population. In light of this, this study aims to comprehensively assess the burden of appendicitis in individuals aged 60 and above based on the 2021 Global Burden of Disease data, in order to provide a basis for formulating corresponding prevention and control strategies for elderly appendicitis.
649. Comprehensive assessment beyond eosinophils in eosinophilic esophagitis: an updated network meta-analysis.
作者: Yangbao Lyu.;Zhi Wu.;Yuming Zhou.;Yue Zhang.;Shuliang Zhao.
来源: BMC Gastroenterol. 2025年25卷1期877页
The rapid development of therapies for eosinophilic esophagitis (EoE), particularly involving biologics and small molecules, has prompted questions about their roles within current treatment algorithms. We aimed to examine the relative efficacy of novel biologics, small molecules and topical steroids by evaluating clinical, endoscopic, and histological improvements.
650. Expression and analysis of NLRP6 in chronic gastritis in children.
Chronic gastritis (CG) in children refers to chronic inflammatory lesions of the gastric mucosa caused by physical, chemical, or biological factors. We investigated the expression of NLRP6 and its downstream factors Caspase-1, IL-1β, and IL-18 in gastric tissues of children with chronic gastritis, and analysed the effect of Helicobacter pylori (Hp) infection on NLRP6 expression.
651. Postoperative dysphagia and short-term outcomes following laparoscopic floppy Nissen fundoplication combined with V-flap suturing.
作者: Haijun Du.;Hongyi Dong.;Ying Gao.;Chuntao Liu.;Xing Du.;Diangang Liu.
来源: BMC Gastroenterol. 2025年25卷1期828页
To compare postoperative dysphagia and anti-reflux efficacy between laparoscopic floppy Nissen fundoplication with V-flap suturing (LNF-V) and conventional laparoscopic Nissen fundoplication (LNF).
653. Impact of venous thromboembolism on mortality in hospitalized patients with inflammatory bowel disease: analysis of the MIMIC-IV database, 2008 to 2022.
作者: Kuang-Te Wang.;Min-I Su.;Wei-Ru Chiou.;Chuan-Lei Chao.;Yi-Fan Huang.;Chun-Han Cheng.
来源: BMC Gastroenterol. 2025年25卷1期825页
Inflammatory bowel disease (IBD)is associated with extraintestinal manifestations, notably venous thromboembolism (VTE), a major cause of morbidity and mortality. Patients with IBD have a 2- to 4-fold increased risk of VTE compared to the general population. Large-scale studies examining associations between VTE and adverse outcomes in hospitalized IBD patients are limited. This study aimed to investigate associations between VTE and mortality (in-hospital and overall) in hospitalized patients with IBD.
654. Compliance and yield of follow-up colonoscopy after a positive FIT in real-life practice: a university hospital experience.
作者: Fady Daniel.;Nada Hamieh.;Batoul Abdallah.;Fayrouz Hachicho.;Dima Malak.;Wafaa Khaled.;Moustafa Al Hattab.;Hassan Sinan.;Omar Mahmoud.;Mohamad Ali Ibrahim.;Ali R Chaitou.;Rudy Mrad.;Ala I Sharara.
来源: BMC Gastroenterol. 2025年25卷1期826页
The fecal immunochemical test (FIT) is a diagnostic modality for colorectal cancer (CRC) screening, with the US Multisociety Task Force setting an 80% adherence benchmark for follow-up colonoscopy (FUC). Guidelines recommend that FITs be performed only in the context of CRC screening.
655. Correlation study of fatty pancreas and fatty liver CT manifestations with biochemical parameters in middle-aged and young adult cholecystectomy patients.
To investigate the correlation between the occurrence of pancreatic steatosis, hepatic steatosis, and cholecystectomy, as well as the associated biochemical parameters.
656. Altered gut microbial functional pathways in people with irritable bowel syndrome enable precision health insights.
作者: Eric Patridge.;Anmol Gorakshakar.;Matthew M Molusky.;Oyetunji Ogundijo.;Cristina Julian.;Lan Hu.;Grant Antoine.;Momchilo Vuyisich.;Robert Wohlman.;Guruduth Banavar.
来源: BMC Gastroenterol. 2025年25卷1期823页
Functional gastrointestinal disorders present diagnostic and therapeutic challenges, and there is a strong need for molecular markers that enable early health insights and intervention. Herein, we present an approach to assess the gut microbiome with stool-based gut metatranscriptome data from a large adult human population (n = 80,570), using irritable bowel syndrome as an example that features both an abnormal gut microbiome and a spectrum of distinct conditions.
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