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521. Targeting the complement system in ANCA-associated vasculitis management.
ANCA-associated vasculitis (AAV) is a group of chronic multisystem inflammatory disorders affecting multiple organs throughout the body. Despite advances in AAV therapies, patients with AAV continue to experience higher rates of mortality than the general population. AAV outcomes can be improved by providing patients with rapid access to multidisciplinary medical teams and early treatment with glucocorticoid- (GC-) based therapy. However, GCs are associated with a high risk of toxicity. The phase 3 ADVOCATE trial demonstrates that blocking the alternative complement pathways using avacopan alongside immunosuppression enables patients with AAV to reduce their GC exposure without compromising efficacy or safety outcomes. ADVOCATE subgroup analyses show benefits for avacopan in patients with a wide range of AAV-related manifestations, disease stages and ages, with the greatest benefits in patients with kidney impairment, lung manifestations and AAV relapse.
522. MTX use in the treatment of RA-associated-interstitial lung disease: a systematic review.
作者: Ines Mahmoud.;Fatma Majdoub.;Selma Bouden.;Leila Rouached.;Olfa Saidane.;Raoudha Tekaya.;Aicha Ben Tekaya.;Leila Abdelmoula.
来源: Rheumatology (Oxford). 2026年65卷3期
To assess the progression of the interstitial lung disease related to RA (RA-ILD) with MTX exposure and to evaluate the lung involvement in RA non-ILD patients with MTX exposure.
523. Assessment of interstitial lung disease in systemic sclerosis using oscillometric methods: a novel approach to respiratory assessment.
作者: İbrahim Vasi.;İbrahim Karaduman.;Şeyma Alacaoğlu.;Serra Duygulu.;Rıza Can Kardaş.;Derya Yıldırım.;Burcugül Kaya.;Rahime Duran.;İbrahim Yahya Çakır.;Esma Eseroğlu.;Burak Karakaya.;Ertuğrul Çağrı Bölek.;Hamit Küçük.;Berna Göker.;Mehmet Akif Öztürk.;Nilgün Yılmaz Demirci.;Abdulsamet Erden.
来源: Rheumatology (Oxford). 2026年65卷1期
Cardiopulmonary involvement is the leading cause of mortality in SSc, and early detection of interstitial lung disease (ILD) is critical to improving outcomes. Conventional spirometry has limitations, whereas impulse oscillometry (IOS) could provide a non-invasive, effort-independent method to detect and monitor pulmonary involvement in these patients. We aimed to evaluate IOS parameters in SSc-ILD, comparing their performance with conventional spirometry.
524. Strong inhibition of IL-6 signal is clinically and serologically effective in refractory adult-onset Still's disease.
作者: Koji Suzuki.;Hideto Kameda.;Kei Ikeda.;Tomonori Ishii.;Kosaku Murakami.;Hyota Takamatsu.;Yoshiya Tanaka.;Takayuki Abe.;Tsutomu Takeuchi.;Yuko Kaneko.
来源: Rheumatology (Oxford). 2026年65卷1期 526. IL-1R/IL-6R blockade for null NLRP12 variant-carrying Takayasu arteritis.
作者: Ourania D Argyropoulou.;Nikolaos M Marinakis.;Georgios Charalampopoulos.;Faidon-Nikolaos Tilemis.;Nikolaos Liasis.;Menelaos N Manoussakis.
来源: Rheumatology (Oxford). 2026年65卷1期 527. Two-decade trajectories of gout: a multicentre cohort study of 10 658 Chinese patients with gout.
作者: Han Qi.;Haibing Chen.;Nicola Dalbeth.;Hui Zhang.;Wei Wang.;Jidong Cheng.;Ying Chen.;Chang Jiang.;Zan Cheng.;Kai Guo.;Lingfang Xu.;Maichao Li.;Changgui Li.;Mingshu Sun.
来源: Rheumatology (Oxford). 2026年65卷1期
The objective of this study was to examine changes of age of onset and disease characteristics of gout between 2003 and 2022 in multiple centres in mainland China.
528. Thrombotic microangiopathy in adult with SAMD9L-associated autoinflammatory disease: a case report of a novel SAMD9L variant.
作者: Ayşe Elif Boncukcuoğlu.;Rabia Deniz.;Fatma Dilara Yürük Kıtay.;Aydeniz Aydın Gümüş.;Cemal Bes.
来源: Rheumatology (Oxford). 2026年65卷1期 529. Effect of treat-to-target strategies on maternal and neonatal outcomes of rheumatoid arthritis: a multicentre real-world ANSWER cohort study.
作者: Yuri Hiramatsu.;Takuya Kotani.;Eri Nakamura.;Ayaka Yoshikawa.;Motomu Hashimoto.;Akira Onishi.;Kouichi Murata.;Natsuki Yamamoto.;Kosaku Murakami.;Toru Hirano.;Yuichi Maeda.;Kosuke Ebina.;Sho Sendo.;Yonsu Son.;Hideki Amuro.;Ryota Hara.;Masaki Katayama.;Wataru Yamamoto.;Tohru Takeuchi.
来源: Rheumatology (Oxford). 2026年65卷1期
We evaluated real-world disease activity, treatment patterns and pregnancy outcomes in women with rheumatoid arthritis (RA) utilizing a multicentre Japanese cohort. Feasibility and impact of a treat-to-target (T2T) approach during pregnancy were also examined.
530. Outpatient hospital attendances in people with rheumatoid arthritis during the COVID-19 pandemic and beyond: a cohort study in three nations of the UK.
作者: Ruth E Costello.;Michael Parker.;Jonathan Kennedy.;Sinead Brophy.;Amir Mehrkar.;Sebastian Bacon.;Ben Goldacre.;Brian MacKenna.;Dave Evans.;Laurie A Tomlinson.;Rosemary J Hollick.;Jenny H Humphreys.; .
来源: Rheumatology (Oxford). 2026年65卷1期
We aimed to estimate how rheumatology outpatient hospital attendances have changed since the COVID-19 pandemic and determine demographic characteristics associated with observed changes.
531. Identification of a distinctive gene signature associated with disease activity in granulomatous myositis.
作者: Iago Pinal-Fernandez.;Nikolas Ruffer.;Maria Casal-Dominguez.;Katherine Pak.;Felix Kleefeld.;Corinna Preusse.;Raphael A Kirou.;Travis B Kinder.;Stefania Del Orso.;Faiza Naz.;Shamima Islam.;Gustavo Gutierrez-Cruz.;Margherita Milone.;Albert Selva-O'Callaghan.;Jose C Milisenda.;Udo Schneider.;Teerin Liewluck.;Werner Stenzel.;Andrew L Mammen.
来源: Rheumatology (Oxford). 2026年65卷1期
Granulomatous myositis (GM) is defined by focal collections of activated macrophages that fuse to form multinucleated cells that aggregate into granulomas within skeletal muscle. This study aimed to elucidate the pathophysiology of GM by defining its specific transcriptomic profile.
532. Fine particulate matter air pollution and anti-nuclear antibodies.
作者: Naizhuo Zhao.;Audrey Smargiassi.;Hong Chen.;May Y Choi.;Marvin J Fritzler.;Zahi Touma.;J Antonio Aviña-Zubieta.;Sasha Bernatsky.
来源: Rheumatology (Oxford). 2026年65卷1期
Air pollution has been increasingly linked to systemic autoimmune rheumatic diseases (SARDs), but studies regarding fine particulate matter (PM2.5) and SARD-related serological biomarkers are limited. We aimed to assess the association between exposure to ambient PM2.5 and ANA in the general population.
533. Real-world data on treatment persistence and measures to minimize cardiovascular risk in rheumatic patients using upadacitinib.
作者: María Vanesa Hernández-Hernández.;Alicia García-Dorta.;Cristina Rodríguez-Regalado.;Andrea Hernández-Martín.;Elena Naveda-González.;Cristina Martínez-González.;Sonia Peña-Montelongo.;Carlos Rodríguez Lozano.;Enrique González-Dávila.;Federico Díaz-González.
来源: Rheumatology (Oxford). 2026年65卷1期
Upadacitinib (UPA), like other Janus kinase inhibitors (JAKis), has regulatory safety warnings related to cardiovascular risk (CVR) and malignancy. This study aims to identify clinical and demographic factors associated with UPA treatment persistence and to assess the impact of CVR safety regulatory recommendations on its prescription patterns in real-world clinical settings.
534. Hormonal risk factors and androgen and glucocorticoid dysregulation in Sjogren's disease and non-Sjogren's sicca.
作者: Jason D Turner.;Jessica Tsapparelli.;Lorna C Gilligan.;Valentina Pucino.;Matilde Bandeira.;Aliaksandra Baranskaya.;Saaeha Rauz.;Ana Poveda-Gallego.;Jon Higham.;Andrea Richards.;Rachel M Brown.;Simon J Bowman.;Angela E Taylor.;Saba Nayar.;Benjamin A Fisher.
来源: Rheumatology (Oxford). 2026年65卷1期
The strong female sex bias in Sjögren's disease (SjD) remains poorly understood. We evaluated hormonal risk factors and steroidal hormones in a well-characterized cohort.
535. Patient experiences and perspectives of DMARD monitoring in Australians with long-disease-duration rheumatoid arthritis and psoriatic arthritis.
作者: Morgan Witts.;Rachelle Buchbinder.;Susan Lester.;Jessica Stanhope.;Vibhasha Chand.;Claire Barrett.;Rachel J Black.;Marissa Lassere.;Lyn March.;Paul Kubler.;Catherine L Hill.;Philip C Robinson.
来源: BMC Rheumatol. 2025年9卷1期126页
Regular laboratory testing is recommended for monitoring disease activity and adverse effects in people taking conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), yet the perspectives and experiences of patients have not been examined and may inform practice. As such, we aimed to determine the experiences and perceptions of laboratory monitoring in Australian adults using csDMARDs for rheumatoid arthritis (RA) or psoriatic arthritis (PsA).
537. Vascular uptake on 18F-FDG PET/CT predicts relapse in new-onset PMR.
作者: Ningqi Dai.;Xinyi Sun.;Linzi Meng.;Jialin Teng.;Chengde Yang.;Xiaoyue Chen.;Huihui Chi.
来源: Rheumatology (Oxford). 2026年65卷1期
In this study, we utilize 18F-fluorodeoxyglucose (FDG) PET/CT to assess vascular involvement in patients with PMR, aiming to clarify its role in identifying subclinical GCA and its potential association with disease relapse.
538. Pharmacological management of spondyloarthritis associated with inflammatory bowel disease: a systematic review of efficacy, safety, and emerging therapies.
作者: Mohammed Khalil Jnyah.;Imane El Mezouar.;Nessrine Akasbi.;Taoufik Harzy.
来源: BMC Rheumatol. 2025年9卷1期125页
Spondyloarthritis (SpA) is a prevalent extraintestinal symptom of inflammatory bowel disease (IBD), impacting up to 20% of patients and considerably contributing to the disease burden. The coexistence of inflammatory bowel disease and spondyloarthritis poses therapeutic problems due to the necessity for simultaneous management of intestinal and musculoskeletal inflammation.
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