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521. Letter by Wu et al Regarding Article, "G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice".524. Response by Hundemer and Vaidya to Letter Regarding Article, "Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study".526. Adaptive AI for Cardiovascular Event Adjudication: Cardiovascular Event Adjudication Across Different Definitions in the ODYSSEY OUTCOMES and EUCLID Trials.
作者: Sreekanth Vemulapalli.;Karla Peña Guerra.;Daniel Wojdyla.;W Schuyler Jones.;Kenneth W Mahaffey.;Robert A Harrington.;Philippe Gabriel Steg.;Gregory G Schwartz.;Manesh R Patel.;Renato D Lopes.;Ricardo Henao.
来源: Circulation. 2026年153卷22期1694-1706页
Clinical end point classification (CEC) is the gold standard for cardiovascular end point measurement in clinical trials but adds time and cost. We developed and validated an artificial intelligence (AI) algorithm (adaptive AI for CEC [ADAPT-CEC]) that adjudicates multiple cardiovascular end points and adapts to new definitions.
527. Effect of APOC3 Inhibition With Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study.
作者: Nicholas A Marston.;Brian A Bergmark.;Thomas A Prohaska.;Filipe A Moura.;André Zimerman.;Veronica J Alexander.;Yu Mi Kang.;Julia Weinland.;Xinhui Ran.;Sabina A Murphy.;Shuanglu Zhang.;Dan Li.;Maciej Banach.;Erik S G Stroes.;Robert Kiss.;Daniel Gaudet.;Michal Vrablik.;Assen Goudev.;Jeroen J Bax.;Matthew J Budoff.;Borek Foldyna.;Michael T Lu.;Sotirios Tsimikas.;Robert P Giugliano.;Marc S Sabatine.
来源: Circulation. 2026年153卷20期1539-1548页
Whether lowering triglyceride-rich lipoproteins and remnant cholesterol favorably modifies coronary atherosclerosis is unclear. Olezarsen, an antisense oligonucleotide that targets apolipoprotein C-III, reduces triglycerides by ~60% and remnant cholesterol by ~70%, has a neutral effect on LDL (low-density lipoprotein) cholesterol (LDL-C), and reduces apoB (apolipoprotein B) by ~15% in moderate hypertriglyceridemia. We investigated the effect of olezarsen on coronary plaque in adults with largely moderate hypertriglyceridemia.
529. Prehospital Heparin Administration in Patients With STEMI Undergoing Primary PCI: HEPARIN-STEMI Randomized Controlled Trial.
作者: Misa Fister.;Marko Noc.;Peter Radsel.;Matjaz Bunc.;Danilo Franco.;Tomaz Goslar.; .
来源: Circulation. 2026年153卷20期1526-1534页
Primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy for patients with ST-segment-elevation myocardial infarction (STEMI). We investigated the benefits and safety of pretreatment with unfractionated heparin (UFH) in patients with STEMI referred to primary PCI.
530. Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Noninferiority Randomized Trial.
作者: Mauro Biffi.;Giovanni Rovaris.;Ennio Carmine Luigi Pisanò.;Valeria Calvi.;Antonio Rapacciuolo.;Matteo Santamaria.;Giampiero Maglia.;Gabriele Zanotto.;Emanuele Bertaglia.;Gerardo Nigro.;Andrea Giomi.;Francesca Notarangelo.;Patrizia Pepi.;Giuliano D'Alterio.;Davide Castagno.;Antonio Dello Russo.;Antonino Nicosia.;Massimo Zecchin.;Matteo Bertini.;Antonio Duca.;Daniele Giacopelli.;Alessio Gargaro.;Giovanni Luca Botto.; .
来源: Circulation. 2026年153卷22期1707-1718页
The role of atrial pacing support is unclear in patients receiving cardiac resynchronization therapy-defibrillator (CRT-D) without sinus node dysfunction.
533. Response by Oikonomou et al to Letter Regarding Article, "Artificial Intelligence-Enabled Echocardiography as a Surrogate for Multimodality Aortic Stenosis Imaging: Post Hoc Analysis of a Clinical Trial".
作者: Evangelos K Oikonomou.;Marc R Dweck.;Rohan Khera.
来源: Circ Cardiovasc Imaging. 2026年19卷4期e019756页 535. Sotatercept for Combined Post- and Precapillary Pulmonary Hypertension Associated With Heart Failure: Results From the Phase 2, Randomized, Placebo-Controlled CADENCE Study.
作者: Mardi Gomberg-Maitland.;Ryan J Tedford.;David Langleben.;Stephan Rosenkranz.;Barry Miller.;Aaron D Jones.;Alessia Urbinati.;Ciaran J McMullan.;Alexandra G Cornell.;Jean-Luc Vachiery.
来源: Circulation. 2026年153卷19期1446-1459页
Combined post- and precapillary pulmonary hypertension in heart failure with preserved ejection fraction involves remodeling in both the heart and pulmonary vasculature. Despite significant mortality, there are no proven therapies.
536. Diagnostic Yield and Safety of Invasive Coronary Function Testing After Radial Versus Femoral Access.
作者: Fleur W Adriaansen.;Caïa Crooijmans.;Tijn P J Jansen.;Behruz Yosofi.;Joan G Meeder.;Yolande Appelman.;Marcel A M Beijk.;Tim P van de Hoef.;Timo Nijkamp.;Hester M den Ruijter.;Annemiek M J de Vos.;Valeria Paradies.;Martijn Meuwissen.;Nicola S Vos.;Els G M Olde Bijvank.;Ibtihal Al Amri.;Melina C den Haan.;Jonathan Halim.;Stijn C H van den Oord.;Karin Arkenbout.;Marlies M Kok.;Pier Woudstra.;Tessel N E Vossenberg.;Nick D Fagel.;Ton A C M Heestermans.;Jan H Cornel.;Niels van Royen.;Suzette E Elias-Smale.;Aukelien C Dimitriu-Leen.;Peter Damman.; .
来源: Circ Cardiovasc Interv. 2026年19卷6期e016450页
Coronary vasomotor dysfunction is diagnosed by a coronary function testing (CFT). However, protocols vary, and the influence of access site and concomitant vasodilator medication on the diagnostic yield and safety of CFT is unclear. This study assessed the diagnostic yield and safety of CFT by radial access with intraarterial calcium channel blockers compared with CFT by femoral access.
538. Prognostic Implications of Bleeding and Ischemic Complications in Acute Myocardial Infarction-Related Cardiogenic Shock Managed With Microaxial Flow Pump.
作者: Takahiro Suzuki.;Taku Asano.;Tomohiro Shinozaki.;Shun Kohsaka.;Takahiro Nakashima.;Masafumi Ono.;Atsushi Mizuno.;Jiro Aoki.; .
来源: Circ Cardiovasc Interv. 2026年19卷4期e015676页
Microaxial flow pumps are emerging therapeutic devices for acute myocardial infarction-related cardiogenic shock. However, prognostic implications of hemorrhagic and ischemic complications on mortality remain limited. We aim to clarify the incidence of these complications in acute myocardial infarction-related cardiogenic shock requiring a microaxial flow pump and their associations with mortality.
539. Multimodality Imaging to Determine Underlying Causes of Myocardial Infarction With Nonobstructive Coronary Arteries in Women and Men.
作者: Harmony R Reynolds.;Akiko Maehara.;Bobby Heydari.;Nathaniel R Smilowitz.;Tara Sedlak.;Yader Sandoval.;Hayder D Hashim.;Kevin R Bainey.;Akl C Fahed.;Natalia Pinilla Echeverri.;Mitsuaki Matsumura.;Mobeen Ahmed.;Jacqueline Saw.;Aun-Yeong Chong.;Atul Sharma.;Anais Hausvater.;Yuhe Xia.;Jennifer A Tremmel.;Shuangbo Liu.;Puja K Mehta.;Bryan Har.;Sripal Bangalore.;Michael Attubato.;Lori Vales Lay.;Alair Holden.;Chang Yu.;Judith S Hochman.; .
来源: Circulation. 2026年153卷21期1606-1622页
Myocardial infarction with nonobstructive coronary arteries (MINOCA) has several underlying causes, including mimicking conditions in some cases. Imaging is recommended to identify MINOCA etiologies, but it remains unclear which patients are most likely to have abnormal findings. We characterized MINOCA mechanisms, analyzed predictors of imaging abnormalities, and explored sex differences.
540. Automated Echocardiographic Detection of Congenital Heart Disease Using Artificial Intelligence.
作者: Platon Lukyanenko.;Sunil J Ghelani.;Yuting Yang.;Bohan Jiang.;Timothy A Miller.;David Harrild.;Nao Sasaki.;Francesca Sperotto.;Danielle Sganga.;John K Triedman.;Andrew J Powell.;Tal Geva.;William G La Cava.;Joshua Mayourian.
来源: Circulation. 2026年153卷21期1623-1636页
Delayed or missed diagnosis of congenital heart disease (CHD) contributes to excess pediatric mortality worldwide. Echocardiography (echo) is central to diagnosing and triaging CHD, yet expert interpretation remains a scarce and maldistributed global resource. Artificial intelligence offers the potential to democratize diagnostics and to extend expert-level interpretation beyond large academic centers, but its application in CHD remains underexplored.
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