513. Geroscience: A Translational Review.
The incidence of stroke, heart failure, dementia, many cancers, coronary artery disease, and physical disability rise exponentially with age. Geroscience is a relatively new discipline that aims to define and modify aging-related biologic pathways, slow age-related disability, prevent age-related diseases, and increase disability-free survival.
515. Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours: The HOPE Randomized Clinical Trial.
作者: Ying Zhou.;Yaode He.;Bruce C V Campbell.;David S Liebeskind.;Changzheng Yuan.;Hui Chen.;Yanxing Zhang.;Tingyu Yi.;Zhongyu Luo.;Zuowen Zhang.;Changcai Meng.;Jianhua Cheng.;Hezhong Ouyang.;Jin Hu.;Fei Wang.;Sheng Zhang.;Qi Fang.;Haitao Hu.;Xuting Zhang.;Yi Chen.;Wansi Zhong.;Maarten G Lansberg.;Shenqiang Yan.;Min Lou.; .
来源: JAMA. 2025年334卷9期788-797页
The safety and efficacy of intravenous thrombolytics beyond 4.5 hours after ischemic stroke onset remain inadequately studied.
|