491. Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial.
作者: D P Devanand.;Thomas Wisniewski.;Qolamreza Razlighi.;Min Qian.;Renjie Wei.;Howard F Andrews.;Edward P Acosta.;Karen L Bell.;Gregory H Pelton.;Deborah Deliyannides.;Allison C Perrin.;Elise Caccappolo.;Anne A Gershon.;K M Prasad.;William C Kreisl.;Akiva Mintz.;Edward D Huey.
来源: JAMA. 2026年335卷6期511-522页
Neuroscientific, epidemiological, and electronic health record studies implicate herpes simplex virus (HSV) as potentially etiological for Alzheimer disease (AD).
494. Head and Neck Cancer: A Review.
Head and neck cancer, which arises in the lining or mucosa of the upper aerodigestive tract, specifically the oral cavity, oropharynx, larynx, hypopharynx, and paranasal sinuses, is the seventh most common cancer worldwide. In 2024, approximately 71 110 individuals in the US were diagnosed with head and neck cancer, and it accounted for 16 110 deaths.
495. The Role of Vaccination in Maternal and Perinatal Outcomes Associated With COVID-19 in Pregnancy.
作者: Elisabeth McClymont.;Sandra Blitz.;Lucia Forward.;Sara Cole.;Gillian D Alton.;Isabelle Boucoiran.;Krista Cassell.;Eliana Castillo.;Joan Crane.;Verena Kuret.;Gaetane LeBlanc Cormier.;Phil A Murphy.;Vanessa Poliquin.;Sarah Saunders.;Heather Scott.;Prakeshkumar Shah.;John W Snelgrove.;Ann E Sprague.;Mark H Yudin.;Deborah Money.; .
来源: JAMA. 2026年335卷2期154-162页
Gaps in knowledge exist about the impact of COVID-19 and vaccination on pregnancy outcomes.
499. Risk-Based vs Annual Breast Cancer Screening: The WISDOM Randomized Clinical Trial.
作者: Laura J Esserman.;Allison S Fiscalini.;Arash Naeim.;Laura J Van't Veer.;Andrea Kaster.;Maren T Scheuner.;Andrea Z LaCroix.;Alexander D Borowsky.;Hoda Anton-Culver.;Olufunmilayo I Olopade.;James Esserman.;Rachael Lancaster.;Lisa Madlensky.;Amie M Blanco.;Katherine S Ross.;Deborah L Goodman.;Barry S Tong.;Michael Hogarth.;Diane Heditsian.;Susie Brain.;Vivian Lee.;Kelly Blum.;Mi-Ok Kim.;Leah P Sabacan.;Kirkpatrick B Fergus.;Christina Yau.;Hannah L Park.;Barbara A Parker.;Celia Kaplan.;Kim F Rhoads.;Suzanne Eder.;Kelly Adduci.;Jeffrey B Matthews.;Neil S Wenger.;Yiwey Shieh.;Robert A Hiatt.;Elad Ziv.;Jeffrey A Tice.;Martin Eklund.
来源: JAMA. 2026年335卷9期763-774页
Individual breast cancer risk can guide screening initiation, frequency, use of supplemental imaging, and preventive measures to improve breast cancer screening by shifting resources from low-risk women to high-risk women.
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