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461. A study on the utility of inflammatory biomarkers in primary care irritable bowel syndrome: a sub analysis of the DOMINO randomized trial.
作者: Celine Tack.;Karen Van den Houte.;Linde Besard.;Luc Capiau.;Steven Ceulemans.;Olivier Gernay.;Sophie Maes.;Christian Peetermans.;Willem Raat.;Jeroen Stubbe.;Rudy Van Boxstael.;Olivia Vandeput.;Sophie Van Steenbergen.;Bjorn Gehesquière.;Jeroen Raes.;Jan Tack.;Florencia Carbone.
来源: BMC Gastroenterol. 2025年26卷1期69页
The role of low-grade-inflammation in Irritable Bowel Syndrome (IBS) a common disorder of gut-brain interaction is unclear. Association with symptom severity, as well as effects of first line treatments are understudied. In a large cohort of primary care IBS patients (DOMINO trial), a FODMAP-lowering diet application was superior in improving symptoms compared to standard medical therapy (otilonium bromide, OB). We investigated the level of pro-inflammatory markers in this IBS cohort and its changes by the DOMINO application and OB.
462. HCV screening among surgical patients in a tertiary hospital of Northern China.
作者: Chunmiao Pang.;Xingjie Niu.;Fangjie Zhang.;Zhihui Liu.;Zhandong Lin.;Liuchang Nie.;Guomin Zhang.
来源: BMC Gastroenterol. 2025年26卷1期63页
The diagnosis and treatment rates for hepatitis C virus (HCV) remain below target levels. This study aims to define and analyze the HCV care cascade for surgical patients in a high-prevalence region, evaluate the impact of a hospital-wide elimination program, and identify barriers and facilitators to completing the diagnostic pathway.
463. The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis.
作者: Peter Rimmer.;Fan Zhang.;Gregor Scott.; .;Georgina L Hold.;Morris Gordon.;Tariq H Iqbal.;Richard Hansen.
来源: Gastroenterology. 2026年170卷3期539-556页
Few studies describe gut microbiome signatures in treatment-naïve new-onset inflammatory bowel disease (IBD). We present a novel secondary bioinformatic reanalysis of sequence outputs mapped to the latest microbial taxonomy.
464. Depletion of Fibrinogen Suppresses Growth of Primary Tumors and Metastasis of Pancreatic Ductal Adenocarcinoma.
作者: Nayela N Chowdhury.;Dana K Mitchell.;Kadri Kangro.;Kierra Eldridge.;Sara Abrahams.;Francesca Ferraresso.;Lih J Juang.;Silpa Gampala.;Kylee Brewster.;Alexey Revenko.;Christian Kastrup.;Paul R Territo.;D Wade Clapp.;Jia Wang.;Jorge A Belgodere.;Omer Saeed.;Sae Rome Choi.;Bumsoo Han.;Alisa S Wolberg.;Sha Cao.;Chi Zhang.;Matthew J Flick.;Melissa L Fishel.
来源: Gastroenterology. 2026年170卷4期753-768页
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic disease that provokes dysregulation of the coagulation system. Patients exhibit significantly elevated circulating levels of blood clotting protein fibrin(ogen). Extravascular fibrin deposits contribute to the complex tumor microenvironment in PDAC.
466. Prognostic Performance of Phosphatidylethanol With Noninvasive Liver Fibrosis Tests in Alcohol-Related Liver Disease.
作者: Nikolaj Torp.;Stine Johansen.;Ellen Lyngbeck Jensen.;Markus Maagaard.;Georg Semmler.;Mette Lehmann Andersen.;Katrine Bech.;Helle Schnefeld.;Katrine Prier Lindvig.;Katrine Holtz Thorhauge.;Ellen Elise Petersen.;Johanne Kragh Hansen.;Ida Falk Villesen.;Peter Andersen.;Marianne Lerbæk Bergmann.;Diana Julie Leeming.;Morten Karsdal.;Camilla Dalby Hansen.;Maja Thiele.;Mads Israelsen.;Aleksander Krag.
来源: Gastroenterology. 2026年170卷4期803-814页
Alcohol is a key driver of liver-related mortality, and phosphatidylethanol (PEth) is a direct biomarker of alcohol intake. We investigated the prognostic performance of PEth with noninvasive liver fibrosis tests (NITs) for predicting hepatic decompensation in an alcohol-related liver disease (ALD) at-risk population.
467. Effect of stent placement on short term survival of left sided obstructive colorectal cancer: comparison of bridge-to-surgery versus emergency surgery approaches.
作者: Yasir Musa Kesgin.;Sezer Bulut.;Seymur Abdullayev.;Burak Suskun.;Ahmet Surek.;Turgut Donmez.;Alpen Yahya Gumusoglu.;Deniz Guzey.;Mehmet Karabulut.
来源: BMC Gastroenterol. 2025年25卷1期880页
A significant proportion of patients with colorectal cancer present to the emergency department. For patients at this stage, the options of emergency resection and stent placement are still being discussed in terms of perioperative, postoperative and survival outcomes. Our study aims to determine which method provides the best survival results for patients who present to the emergency department with colorectal cancer-related obstruction in the first three years.
469. The SENENDO Volunteer Mission - A Training and Care Delivery Model That Addresses Lacking Digestive Endoscopy Resources in Sub-Saharan Africa.
作者: Gabriel Rahmi.;Ibrahima Diallo.;Mamadou Ngone Gueye.;Pape Saliou Mbaye.;Alan N Barkun.; .
来源: Gastroenterology. 2025年 471. Safety of long vs. short fasting after ESD/STER for esophageal tumors ≤ 2 cm: a propensity score-matching study.
作者: Kang Li.;Foqiang Liao.;Taiyu Chen.;Zhenhua Zhu.;Xiaolin Pan.;Shunhua Long.;Guohua Li.;Xiaojiang Zhou.;Youxiang Chen.;Yin Zhu.;Xu Shu.
来源: BMC Gastroenterol. 2025年26卷1期62页
Endoscopic submucosal dissection (ESD) and submucosal tunneling endoscopic resection (STER) have become the safe and effective techniques for early-stage esophageal cancer and small-diameter submucosal tumors of the esophagus. Yet, there remains insufficient research on the appropriate fasting period following ESD or STER in patients with early esophageal neoplasms. This study aims to assess the impact of different fasting durations-long versus short-on postoperative complication rates and hospital stay durations.
473. Characteristics and outcomes of patients undergoing esophagogastroduodenoscopy in Gaza strip hospitals: a retrospective study.
作者: Tayseer Afifi.;Khamis Elessi.;Mosheer Al-Dahdouh.;Hasan Hamdan.;Ahmed Eid.;Khaled Siyam.;Mustafa Abu Jayyab.;Isam Awadallah.
来源: BMC Gastroenterol. 2025年26卷1期61页
Upper gastrointestinal (GI) disorders represent a major cause of morbidity worldwide, and esophagogastroduodenoscopy (EGD) remains the gold standard for both diagnosis and therapeutic guidance. In resource-limited settings such as the Gaza Strip, the utilization of EGD provides critical insights into disease burden, patient characteristics, and clinical outcomes. This study aimed to evaluate the demographic characteristics, clinical indications, endoscopic findings, and management outcomes of patients undergoing EGD at the Gaza Strip Hospitals.
474. Risk assessment of digestive cancers with the modified EAT-Lancet diet pattern: a prospective cohort study based on UK Biobank.
作者: Daixin Wu.;Junwei Huang.;Juncheng Chen.;Zhengyu Wu.;Jiale Jiang.;Yuan Yuan.;Rufu Chen.;Chonghui Hu.;Yong Jiang.;Shangyou Zheng.
来源: BMC Gastroenterol. 2025年26卷1期60页
While diet is a modifiable risk factor for digestive cancers, existing dietary scores are not optimized for site-specific risk assessment. We aimed to develop and evaluate cancer-specific dietary scores for improved risk stratification.
475. Sex differences in the association between red cell distribution width and 30-day mortality in critically ill patients with acute cholangitis: a retrospective cohort study.
Acute cholangitis (AC) is an emergency disease with a high risk of mortality. Red cell distribution width (RDW) has been proven to correlate with the adverse outcomes of several clinical conditions. The present study aims to investigate the association between RDW and 30-day mortality in critical AC.
476. Observational study of Reflux-related findings at distal esophagus, gastric pouch, and anastomotic site one and three years after one-anastomosis gastric bypass: exploring the diagnostic accuracy of endoscopy compared to biopsy.
We aimed to compare upper endoscopy (UE) with histopathology (biopsy) for detecting reflux-related findings at 1 and 3 years following one-anastomosis gastric bypass (OAGB).
477. Aspirin reduces short-term mortality risk in critically ill patients with liver cirrhosis: a propensity-score matched retrospective analysis using the MIMIC-IV database.
Liver cirrhosis not only leads to high mortality but also imposes significant economic burdens and health losses. Aspirin is a drug with potential indications for liver disease, but its benefits in cirrhosis have primarily been demonstrated in outpatient settings. This study aimed to determine whether aspirin therapy confers protective effects on the prognosis of critically ill cirrhosis patients.
478. Inverse association of alcohol consumption patterns with constipation and diarrhea: a population-based cross-sectional study.
Constipation and diarrhea are prevalent gastrointestinal health issues that significantly impact productivity and daily life, often leading to psychological problems and exacerbating public health burdens. Alcohol is a commonly consumed beverage worldwide, and previous studies suggest that it may exert certain effects on the gastrointestinal tract. Investigating the relationship between patterns of alcohol consumption and the presence of gastrointestinal symptoms such as constipation or diarrhea can aid in the formulation of public health strategies and improve management plans for alcohol use and gastrointestinal health.
479. Multimodal patient education improves bowel preparation for colonoscopy: a randomized controlled trial.
作者: Moath Hattab.;Mohammed Shakhshir.;Carmel Khalil.;Raw'a Mletat.;Razan Rabi.;Raya Yassin.;Malek Hejaz.;Mohammed M Hajhamad.
来源: BMC Gastroenterol. 2025年26卷1期54页
Inadequate bowel preparation (BP) compromises colonoscopy quality, efficiency, and patient outcomes. We evaluated whether a resource-light multimodal educational package improves BP adequacy compared with standard instructions.
480. MiR-199b-5p inhibition improves inflammation and oxidative stress damage in OA-induced non-alcoholic fatty liver disease through targeting SIRT1.
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease. This research investigates the role of miR-199b-5p in NAFLD development.
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