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401. Small Cell Lung Cancer: A Review.
Small cell lung cancer (SCLC) is a high-grade neuroendocrine carcinoma with an incidence of 4.7 cases per 100 000 individuals in 2021 in the US and a 5-year overall survival of 12% to 30%.
403. Discordance of 10- and 30-Year Predicted Risk for Cardiovascular Disease in US Adults.
作者: Vaishnavi Krishnan.;Xiaoning Huang.;Amanda M Perak.;Josef Coresh.;Chiadi E Ndumele.;Philip Greenland.;Donald M Lloyd-Jones.;Sadiya S Khan.
来源: JAMA. 2025年333卷20期1828-1831页 404. Intravenous Ferric Carboxymaltose in Heart Failure With Iron Deficiency: The FAIR-HF2 DZHK05 Randomized Clinical Trial.
作者: Stefan D Anker.;Tim Friede.;Javed Butler.;Khawaja M Talha.;Marius Placzek.;Monika Diek.;Anna Nosko.;Adriane Stas.;Stefan Kluge.;Dominik Jarczak.;Geraldine deHeer.;Meike Rybczynski.;Antoni Bayés-Genís.;Michael Böhm.;Andrew J S Coats.;Frank Edelmann.;Gerasimos Filippatos.;Gerd Hasenfuß.;Wilhelm Haverkamp.;Mitja Lainscak.;Ulf Landmesser.;Iain C Macdougall.;Bela Merkely.;Burkert M Pieske.;Fausto J Pinto.;Tienush Rassaf.;Jennifer K Visser-Rogers.;Giuseppe Rosano.;Maurizio Volterrani.;Stephan von Haehling.;Markus S Anker.;Wolfram Doehner.;Hüseyin Ince.;Friedrich Koehler.;Gianluigi Savarese.;Muhammad Shahzeb Khan.;Ursula Rauch-Kröhnert.;Tommaso Gori.;Teresa Trenkwalder.;Ibrahim Akin.;Christina Paitazoglou.;Iwona Kobielusz-Gembala.;Luca Kuthi.;Norbert Frey.;Manuela Licka.;Stefan Kääb.;Karl-Ludwig Laugwitz.;Piotr Ponikowski.;Mahir Karakas.
来源: JAMA. 2025年333卷22期1965-1976页
Uncertainty remains about the efficacy of intravenous iron in patients with heart failure and iron deficiency.
405. Cardiac Arrest During Long-Distance Running Races.
作者: Jonathan H Kim.;Austin J Rim.;James T Miller.;Mekensie Jackson.;Neeya Patel.;Sanchitha Rajesh.;Yi-An Ko.;Heather DiGregorio.;George Chiampas.;David McGillivray.;Jay Holder.;Aaron L Baggish.
来源: JAMA. 2025年333卷19期1699-1707页
More than 29 million participants completed marathons and half-marathons in the US between 2010-2023, approximately 3 times the number from 2000-2009. Contemporary long-distance race-related cardiac arrest incidence and outcomes are unknown.
407. Iron Deficiency in Adults: A Review.
Absolute iron deficiency, defined as low iron stores with or without anemia, affects approximately 2 billion people worldwide and 14% of adults in the US. Iron-deficiency anemia, defined as low hemoglobin due to low iron stores, affects approximately 1.2 billion people worldwide, including 10 million in the US.
409. Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial.
作者: Keyvan Karkouti.;Jeannie L Callum.;Justyna Bartoszko.;Kenichi A Tanaka.;Sigurd Knaub.;Sukhpal Brar.;Kamrouz Ghadimi.;Antoine Rochon.;Darren Mullane.;Etienne J Couture.;Yulia Lin.;Christopher Harle.;Michelle Zeller.;Diem T T Tran.;Cristina Solomon.;Vivek Rao.;Michael Law.;Amir L Butt.;Edward P Chen.;Maria Rosal Martins.;Tarit Saha.;Andrew W Shih.;Marie-Claude Vézina.;Fuad Moussa.;Raffael Pereira Cezar Zamper.;Summer Syed.;Hakan Buyukdere.;Sylvia Werner.;Deep Grewal.;Daniel Wong.;Kofi B Vandyck.;Robert Tanzola.;Bevan Hughes.;Olivier Royer.;Sophia Wong.;Jerrold H Levy.; .
来源: JAMA. 2025年333卷20期1781-1792页
Excessive bleeding is a common and prognostically important complication of cardiac surgery. For bleeding related to coagulation factor deficiency, frozen plasma is the most used therapy. Preliminary trials indicate that 4-factor prothrombin complex concentrate (PCC) may be a suitable alternative.
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