403. Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes : A Secondary Analysis of a Randomized Controlled Trial.
作者: Miguel Ruiz-Canela.;Dolores Corella.;Miguel Ángel Martínez-González.;Nancy Babio.;J Alfredo Martínez.;Luis Forga.;Ángel M Alonso-Gómez.;Julia Wärnberg.;Jesús Vioque.;Dora Romaguera.;José López-Miranda.;Ramón Estruch.;José Manuel Santos-Lozano.;Luis Serra-Majem.;Aurora Bueno-Cavanillas.;Josep A Tur.;Vicente Martín-Sánchez.;Antoni Riera-Mestre.;Miguel Delgado-Rodríguez.;Pilar Matía-Martín.;Josep Vidal.;Clotilde Vázquez.;Lidia Daimiel.;Pilar Buil-Cosiales.;Sangeetha Shyam.;Jose V Sorlí.;Olga Castañer.;Antonio García-Rios.;Laura Torres-Collado.;Enrique Gómez-Gracia.;M Ángeles Zulet.;Jadwiga Konieczna.;Rosa Casas.;Naomi Cano-Ibáñez.;Lucas Tojal-Sierra.;Rosa M Bernal-López.;Estefanía Toledo.;Jesús García-Gavilán.;Rebeca Fernández-Carrión.;Albert Goday.;Antonio P Arenas-Larriva.;Sandra González-Palacios.;Helmut Schröder.;Emilio Ros.;Montserrat Fitó.;Frank B Hu.;Francisco J Tinahones.;Jordi Salas-Salvadó.
来源: Ann Intern Med. 2025年178卷10期1378-1389页
Limited research has been done to evaluate the combined effect of energy reduction, Mediterranean diet (MedDiet), and physical activity on type 2 diabetes incidence.
405. High-Concentration Delta-9-Tetrahydrocannabinol Cannabis Products and Mental Health Outcomes : A Systematic Review.
作者: Thanitsara Rittiphairoj.;Louis Leslie.;Jean-Pierre Oberste.;Tsz Wing Yim.;Gregory Tung.;Lisa Bero.;Paula Riggs.;Kent Hutchison.;Jonathan Samet.;Tianjing Li.
来源: Ann Intern Med. 2025年178卷10期1429-1440页
Rapid changes in the legalized cannabis market have led to the predominance of high-concentration delta-9-tetrahydrocannabinol (THC) cannabis products.
409. Long-Term Routine Laboratory Toxicity Monitoring of Immunomodulatory Drugs in Rheumatoid Arthritis : A Retrospective Cohort Study.
作者: Evy Ulijn.;Nathan den Broeder.;Karen Bevers.;Rosalie Pruijs.;Bram van Es.;Tjebbe Tauber.;Robert Landewé.;Noortje van Herwaarden.;Alfons A den Broeder.
来源: Ann Intern Med. 2025年178卷10期1400-1408页
Scarcity of data on the value of long-term routine laboratory toxicity monitoring (lt-RLTM) during disease-modifying antirheumatic drug (DMARD) use results in frequent monitoring in clinical practice.
420. Effect of Systolic Blood Pressure Measurement Error on the Cost-Effectiveness of Intensive Blood Pressure Targets.
作者: Karen C Smith.;Thomas A Gaziano.;Alvin I Mushlin.;David M Cutler.;Nicolas A Menzies.;Ankur Pandya.
来源: Ann Intern Med. 2025年178卷10期1409-1419页
Analyses of clinical trials find that an intensive systolic blood pressure (SBP) target of less than 120 mm Hg is cost-effective compared with a target of less than 140 mm Hg for patients at high cardiovascular disease risk. However, guidelines from the American College of Cardiology and American Heart Association recommend a target of less than 130 mm Hg, citing blood pressure measurement error in routine practice.
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