Colorectal cancer screening reduces mortality, yet uptake remains suboptimal. Various interventions aim to improve screening rates, but their comparative effectiveness is unclear. We aim to evaluate the effectiveness of colorectal cancer screening uptake interventions using a systematic review and network meta-analysis.

The burden of chronic liver disease is rapidly increasing worldwide, driven primarily by metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic and alcohol-associated liver disease (MetALD), and alcohol-associated liver disease (ALD). Genetic predisposition contributes substantially to variability in disease onset, progression, and outcomes, and recent advances in genomic discovery have brought polygenic risk scores (PRS) and targeted sequencing closer to clinical relevance. This review summarizes the role of genetic testing in clinical hepatology, including monogenic drivers of disease and the growing role of common variants and PRS. Specific populations, including cryptogenic cirrhosis and lean MASLD patients, may be enriched for monogenic drivers of disease. In addition, patients with chronic liver disease may benefit from incorporation of genetic risk scores including PNPLA3, TM6SF2, HSD17B13, and other key variants in determining risk for fibrosis progression and cirrhosis. Across MASLD and ALD, PRS demonstrate modest improvements in predicting fibrosis progression and liver-related events, especially when integrated with clinical risk factors and comorbidities. However, their performance remains limited for population-level screening. Similarly, PRS alone has limited diagnostic accuracy for hepatocellular carcinoma and more complex models with clinical features and multi-omic biomarkers are likely needed. Emerging therapies targeting PNPLA3 and HSD17B13 variants represent a paradigm shift toward genetically informed treatment. Yet challenges remain, including limited ancestral diversity in genomic datasets, pleiotropic effects of variants, cost-effectiveness, and the need for integration with other omics and electronic medical records. As evidence matures, combining genetic risk with clinical and environmental factors may enable more personalized approaches to prognostication and therapy in liver disease.

Autoimmune atrophic gastritis causes achlorhydria, which may predispose to gastrointestinal microbial overgrowth (MO). We sought to evaluate the association between autoimmune atrophic gastritis and MO.

The use of mesalamine for the treatment of ulcerative colitis (UC) is common, and may rarely cause nephrotoxicity. One of the clinical signs of nephropathy is hematuria or dark urine. We aimed to evaluate the effect of hypochlorous acid (HA) found in household bleach on the color of urine among pediatric UC subjects treated with mesalamine.

Serrated polyps account for up to 30% of colorectal cancer cases and are linked to interval cancers. Due to their clinical relevance and frequent underdiagnosis, this study evaluated the epidemiological profile, endoscopic and histopathological characteristics, and subtypes of serrated polyps, including those occurring synchronously with conventional adenomas.

Esophageal cancer (EC) is one of the most common malignant tumors in China, with the number of new cases and deaths accounting for about half of the global total, imposing a heavy burden of disease. The latest epidemiological statistics on EC can help policymakers allocate resources for EC prevention, treatment, and care.

Current treatment strategies for symptomatic uncomplicated diverticular disease (SUDD) remain controversial. Nutraceuticals could be potential adjuvant treatments to reduce symptoms and improve Quality of Life (QoL).

The distinction between benign and neoplastic bile duct strictures remains challenging. Pathologic assessment of ERCP-obtained specimens has limited sensitivity, particularly among patients with primary sclerosing cholangitis (PSC). Next-generation sequencing (NGS) of bile duct specimens provides a promising diagnostic approach; but a prospective, multi-institutional, and comprehensive DNA/RNA analysis is lacking.