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262. Outcome of a FODMAP restriction diet with subsequent blinded reintroduction in functional dyspepsia/postprandial distress syndrome.
作者: Karen Van den Houte.;Bert Broeders.;Joran Tóth.;Karen Routhiaux.;Zoë Mariën.;Jasmien Van den Bergh.;Julie Vanderstappen.;Nelle Pauwels.;Ann Meulemans.;Christophe Matthys.;Tim Vanuytsel.;Florencia Carbone.;Jan Tack.
来源: Gut. 2025年75卷1期57-64页
Recent studies have shown increased duodenal mucosal permeability as a possible key player in the pathophysiology of functional dyspepsia (FD). Adverse reaction to nutrients is an important candidate underlying mechanism. Intragastric infusion of fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) induced symptoms reminiscent of FD with a rapid onset.
265. Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota.
作者: Eiji Miyauchi.;Takashi Taida.;Kan Uchiyama.;Yumiko Nakanishi.;Tamotsu Kato.;Shigeo Koido.;Nobuo Sasaki.;Toshifumi Ohkusa.;Nobuhiro Sato.;Hiroshi Ohno.
来源: Gut. 2025年75卷1期46-56页
The aetiology and pathogenesis of IBD are intricate, involving genetic and environmental factors. Notably, cigarette smoking has contrasting effects, being detrimental to Crohn's disease (CD) and beneficial to UC. However, the mechanisms underlying these opposite effects remain unclear.
268. Comparative risk of high-risk neoplasia after polypectomy among individuals aged below 50 years versus 50 years and older.
作者: Yufeng Chen.;Jean Padilla Aponte.;Kai Wang.;Mengxi Du.;Yujia Lu.;Georgios Polychronidis.;Mingyang Song.
来源: Gut. 2025年75卷1期72-80页
Limited evidence supports colonoscopy surveillance practices among individuals aged <50 years.
270. Single-cell multimodal analysis reveals the dynamic immunopathogenesis of HBV-ACLF progression.
作者: Xi Liang.;Jinjin Luo.;Qian Zhou.;Jiaojiao Xin.;Jiaqi Li.;Bo Peng.;Meiqian Hu.;Jing Jiang.;Wei Qiang.;Peng Li.;Pengcheng Chen.;Heng Yao.;Huafen Zhang.;Xingping Zhou.;Jiaxian Chen.;Wen Hu.;Bingqi Li.;Shiwen Ma.;Xiao Wu.;Xiao Li.;Jing Zhang.;Jinlin Cheng.;Shourong Liu.;Xiaoqing Fu.;Yingyan Lu.;Yingzi Ming.;Xin Chen.;Dongyan Shi.;Jun Li.
来源: Gut. 2026年75卷2期367-381页
Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome involving dysfunction of multiple immune cell types.
273. Real-world validation of a prognostic clinical index to predict steroid response in acute severe colitis: a single tertiary centre retrospective study.
作者: Vincent Bouillon.;Christophe De Terwangne.;Claire Liefferinckx.;Charlotte Minsart.;Leila Amininejad.;Denis Franchimont.;Anneline Cremer.
来源: Gut. 2025年75卷1期194-195页 274. ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation.
作者: Yue Yuan.;Jiaxuan Li.;Dean Rao.;Xun Lu.;Min Chen.;Xiaoping Chen.;Xin Long.;Bixiang Zhang.;Huifang Liang.;Qian Chen.;Jianping Zhao.
来源: Gut. 2025年
Interferon (IFN)-stimulated gene 15 (ISG15) is a downstream molecule of the IFN pathways central to many cellular processes. ISG15 mainly exerts its function through a post-translational modification process known as ISGylation.
276. Artificial intelligence-tailored bowel preparation reduces laxative burden and promotes sustainable endoscopy.
作者: Yang-Bor Lu.;Si-Cun Lu.;Yung-Ning Huang.;Yu-Chieh Weng.;Tung-Ying Chiang.;Pei-Ting Cheng.;Puo-Hsien Le.;Cheng-Tang Chiu.;Ankie T Cheung.;Dorothy Chan.;Raymond Sy Tang.;Xiao-Bing Cui.;Hong-Zhi Xu.;Shun-Tian Cai.;Joseph Jy Sung.;Thomas Yt Lam.;Wei Gong.
来源: Gut. 2025年 277. Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes.
作者: Fernando Lucas-Ruiz.;Daniel Vidal-Correoso.;Sandra V Mateo.;María Magdalena de la Torre-Álamo.;Marta Jover-Aguilar.;Felipe Alconchel.;Laura Martínez-Alarcón.;Víctor Lopez-Lopez.;Antonio Ríos-Zambudio.;Pedro Cascales.;Pablo Pelegrín.;Jose Antonio Pons.;Pablo Ramírez.;Alberto Baroja-Mazo.
来源: Gut. 2025年74卷12期2058-2069页
Liver transplantation (LT) remains hampered by post-transplant complications. While gut microbiota dysbiosis has been linked to transplant outcomes, the role of the intrahepatic graft's native microbiota remains unexplored.
278. Clinical results of an HBV-specific T-cell receptor-T-cell therapy (SCG101) in patients with HBV-related hepatocellular carcinoma treated in an investigator-initiated, interventional trial.
作者: Xiang'an Wu.;Dongmei Quan.;Wei Li.;Karin Wisskirchen.;Wei Wu.;Yuhong Zhou.;Yun-Peng Liu.;Xueshuai Wan.;Xiaorui Wang.;Xuxu Zhang.;Lu Yang.;Mengyao Zheng.;Ke Zhang.;Ulrike Protzer.;Shunda Du.;Xiujuan Qu.
来源: Gut. 2025年75卷1期147-160页
SCG101 is an autologous T-cell therapy specifically targeting hepatitis B virus (HBV) using a natural, high-affinity T-cell receptor that is stably expressed.
279. Mucosal transcriptomic landscape along the small and large intestines in individuals with and without type 2 diabetes.
作者: Hannah Gilliam-Vigh.;Anne Marie Ellegaard.;Martin Rønn Madsen.;Asger Bach Lund.;Benjamin Anderschou Holbech Jensen.;Tina Vilsbøll.;Kristoffer Rigbolt.;Filip Krag Knop.
来源: Gut. 2025年75卷1期33-45页
A detailed mapping of functional differences among intestinal regions in healthy individuals remains incomplete. Identifying regional alterations in individuals with type 2 diabetes (T2D) could enhance our understanding of disease-related intestinal changes.
280. Global prevalence and gastrointestinal symptom burden of individuals with a history of cholecystectomy.
作者: Bo Konings.;Lukas Michaja Balsiger.;Johann Pall Hreinsson.;Magnus Simrén.;Shrikant I Bangdiwala.;Ami D Sperber.;Olafur S Palsson.;Hans Törnblom.;Jan Tack.
来源: Gut. 2025年75卷1期65-71页
Cholecystectomy is commonly performed globally, and many patients with disorders of gut-brain interaction (DGBI) report that their symptoms have either preceded or developed following cholecystectomy.
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