2339. Zerlasiran-A Small-Interfering RNA Targeting Lipoprotein(a): A Phase 2 Randomized Clinical Trial.
作者: Steven E Nissen.;Qiuqing Wang.;Stephen J Nicholls.;Ann Marie Navar.;Kausik K Ray.;Gregory G Schwartz.;Michael Szarek.;Erik S G Stroes.;Roland Troquay.;Jannick A N Dorresteijn.;Henry Fok.;David A Rider.;Steven Romano.;Kathy Wolski.;Curtis Rambaran.
来源: JAMA. 2024年332卷23期1992-2002页
Elevated lipoprotein(a) increases the risk of atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis.
2340. Oral Muvalaplin for Lowering of Lipoprotein(a): A Randomized Clinical Trial.
作者: Stephen J Nicholls.;Wei Ni.;Grace M Rhodes.;Steven E Nissen.;Ann Marie Navar.;Laura F Michael.;Axel Haupt.;John H Krege.
来源: JAMA. 2025年333卷3期222-231页
Muvalaplin inhibits lipoprotein(a) formation. A 14-day phase 1 study demonstrated that muvalaplin was well tolerated and reduced lipoprotein(a) levels up to 65%. The effect of longer administration of muvalaplin on lipoprotein(a) levels in individuals at high cardiovascular risk remains uncertain.
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