当前位置: 首页 >> 检索结果
181. A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis.
作者: Yu Chen.;Wanneng Li.;Shuhui Wang.;Han Wang.;Jiaxin Xu.;Meiping Yu.;Lijia Wang.;Zhenghao Ye.;Xinmei Yan.;Zhuoying Lin.;Ping Han.;Fang Xiao.;Wei Yan.;Dean Tian.;Yu Lei.;Mei Liu.
来源: Gut. 2025年
Autoimmune hepatitis (AIH) is characterised by death of hepatocytes and chronic inflammation. Patients with deleterious variants in A20 are identified with AIH presentations and immune activation. However, it remains unclear how A20 dysregulation contributes to AIH pathogenesis.
182. Peginterferon alpha-2a add-on to siRNA JNJ-73763989 in untreated patients with HBeAg-positive chronic hepatitis B virus (HBV) infection: the phase 2 REEF-IT study.
作者: Patrick T F Kennedy.;Scott Fung.;Maria Buti.;Gurdal Yilmaz.;Wan-Long Chuang.;Tarik Asselah.;Masayuki Kurosaki.;John Jezorwski.;Vladislav Klyashtornyy.;Thierry Verbinnen.;Thomas Naoki Kakuda.;Oliver Lenz.;Carine Guinard-Azadian.;Michael Biermer.
来源: Gut. 2025年
In the hepatitis B e antigen positive (HBeAg+) chronic infection disease phase, approved treatments have limited effects on hepatitis B surface antigen (HBsAg) and HBeAg.
183. Spatial profiling of patient-matched HER2 positive gastric cancer reveals resistance mechanisms to targeted therapy.
作者: Taotao Sheng.;Raghav Sundar.;Supriya Srivastava.;Xuewen Ong.;Su Ting Tay.;Haoran Ma.;Tomoyuki Uchihara.;Benedict Shi Xiang Lian.;Takeshi Hagihara.;Mei Suen Kong.;Chang Xu.;Shamaine Wei Ting Ho.;Kie Kyon Huang.;Angie Lay Keng Tan.;Michelle Shu Wen Ng.;Jiamin Toh.;Clara Shi Ya Ng.;Vincenzo Nasca.;Chiara Carlotta Pircher.;Giovanni Randon.;Silvia Giordano.;Simona Corso.;Jeffrey Huey Yew Lum.;Ming Teh.;Joseph J Zhao.;Jimmy Bok Yan So.;Giovanna Sabella.;Shyam Prabhakar.;Jeeyun Lee.;Wei Peng Yong.;Matthew Chau Hsien Ng.;Kohei Shitara.;Jessica Gasparello.;Matteo Fassan.;Filippo Pietrantonio.;Patrick Tan.
来源: Gut. 2026年75卷4期733-747页
Human epidermal growth factor receptor 2 (HER2; ERBB2) is overexpressed or amplified in 15-20% of gastric cancers (HER2+ GC). Within individual HER2+ GCs, HER2/ERBB2 expression is often variable. Although HER2 therapeutic targeting improves outcomes for HER2+ GC patients, acquired resistance is frequent.
184. Pharmacological trials of early intervention in predicted severe acute pancreatitis: implications for therapeutic window and core outcome set.
作者: Juan Lin.;Wenhao Cai.;Arjun Kattakayam.;Wenhua He.;Lu Ke.;Peter Szatmary.;Tingting Liu.;Vikesh Singh.;Rajarshi Mukherjee.;Wei Huang.;Robert Sutton.
来源: Gut. 2025年 186. Sampling the incisura angularis for the assessment of gastritis: preliminary insights from a systematic review.
作者: Luiza Fenelon.;Marcelo Cristalli Pacheco da Costa.;Matheus Vanzin Fernandes.;Diogo Bergesch Diedrich.;Murilo Cavalcante Netto do Carmo.;João Ricardo Duda.;Beanie Conceição Medeiros Nunes.;Matheus Cavalcante Franco.;Stefano Baraldo.;Robert M Genta.
来源: Gut. 2025年 187. EASL 2025 indications revisited: phase-specific outcomes with and without nucleos(t)ide analogue therapy in chronic hepatitis B virus infection.
作者: Shichuan Tang.;Tingfeng Huang.;Ruijing Tang.;Kongying Lin.;Cong Luo.;Yubing Shen.;Kailing Zhang.;Yidan Tang.;Jie Kong.;Zhenwei Chen.;Jun Fu.;Qizhu Lin.;Luobin Guo.;Yeye Wu.;Yuntong Li.;Jianxi Zhang.;Zhenghong Sun.;Penghui You.;Daichang Zhang.;Yanxin Chen.;Xin Lin.;Chengqian Zhong.;Zhipeng Lin.;Hongzhi Liu.;Zuxiong Huang.;Weiping Zhou.;Peiling Dong.;Xiaolong Liu.;Hongmei Zeng.;Xiaolong Qi.;Yongyi Zeng.
来源: Gut. 2025年
The impact of nucleos(t)ide analogues (NAs) therapy on the long-term outcomes in chronic HBV infection individuals outside 2025 European Association for the Study of the Liver (EASL) strongly recommended treatment indications remains uncertain. We aimed to assess the association between NAs therapy and the risks of cirrhosis and hepatocellular carcinoma (HCC) in Chinese chronic HBV infection individuals outside these criteria.
188. Dynamic urinary proteomics integrates single-cell and spatial transcriptomics to reveal tumour microenvironment and predict immunotherapy response in biliary tract cancer.
作者: Shanshan Wang.;Zhengguang Guo.;Boyu Sun.;Kai Liu.;Jiashuo Chao.;Ziyu Xun.;Yunchao Wang.;Zibo Xu.;Ziyue Huang.;Hao Wang.;Yang Tan.;Nan Zhang.;Mingjian Piao.;Longhao Zhang.;Chengjie Li.;Shuofeng Li.;Jiongyuan Li.;Haidan Sun.;Feng Qi.;Aiwei Wang.;XiaoBo Yang.;Chengpei Zhu.;Hanping Wang.;Wei Sun.;Haitao Zhao.
来源: Gut. 2025年
Most patients with biliary tract cancer (BTC) do not derive durable clinical benefit (DCB) from immune checkpoint inhibitors (ICIs), underscoring the urgent need for predictive biomarkers. While urinary proteomics represents a non-invasive approach for biomarker discovery and mechanism exploration, its utility in ICI-treated patients with cancer remains unexplored.
189. Global prevalence of self-reported non-coeliac gluten and wheat sensitivity: a systematic review and meta-analysis.
作者: Mohamed G Shiha.;Francesca Manza.;Oscar G Figueroa-Salcido.;Noé Ontiveros.;Giacomo Caio.;Claire L Jansson-Knodell.;Alberto Rubio-Tapia.;Imran Aziz.;David S Sanders.
来源: Gut. 2025年
Non-coeliac gluten/wheat sensitivity (NCGWS) is characterised by gastrointestinal and extraintestinal symptoms related to gluten or wheat ingestion in individuals without coeliac disease or wheat allergy.
190. Profiles of quantitative hepatitis B surface antigen in patients with chronic hepatitis B.
作者: Jian Wang.;Tao Fan.;Li Zhu.;Shaoqiu Zhang.;Ye Xiong.;Chao Jiang.;Juan Xia.;Renling Yao.;Xiaomin Yan.;Xingxiang Liu.;Chuanwu Zhu.;Chao Wu.;Rui Huang.
来源: Gut. 2025年 191. Characteristics of an antibody profile associated with protection against hepatitis C virus reinfection in a high-risk cohort.
作者: Ana Luz Chumbe.;Suzanne M D van den Aardweg.;Anders Boyd.;Marloes Grobben.;Sylvie M Koekkoek.;Ian Zon.;Maria Prins.;Kwinten Sliepen.;Marit J van Gils.;Janke Schinkel.
来源: Gut. 2025年
Without a vaccine, HCV (re)infections continue to afflict individuals at high risk, for example, men who have sex with men (MSM).
192. First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia.
作者: Sandeep Grover.;Ines Gockel.;Anna Latiano.;Anna Mokrowiecka.;Pouria Dasmeh.;Mira M Wouters.;Zuzana Vackova.;Stephan L Haas.;Tania Triantafyllou.;Nicole Kreuser.;Jessica Trautmann.;Stefan Niebisch.;Timo Hess.;Rene Thieme.;Jessica Bigge.;Hubert Louis.;Eric Quertinmont.;Aline Meirhaeghe.;Manon Muntaner.;Philippe Amouyel.;Guillaume Gourcerol.;Stanislas Bruley des Varannes.;Francois Mion.;Michael Vieth.;Nikolaos Scarmeas.;Orazio Palmieri.;Francesca Tavano.;Roberto De Giorgio.;Daniela Galimberti.;Andrea Arighi.;Beatrice Arosio.;Marco Bruno.;Justyna Wasielica-Berger.;Magdalena Gawron-Kiszka.;Maria Janiak.;Magdalena Siepsiak.;Krystian Adrych.;Tomasz Marek.;Andrzej Dabrowski.;Marek Majewski.;Piotr Gietka.;Maciej Gonciarz.;Julio Pérez de la Serna.;Laisy Zacarías Martínez.;Vilmantas Giedraitis.;Lena Kilander.;Laura Fratiglioni.;Luis Miguel Real.;Julius Spicak.;Jan Tack.;Stefanie Heilmann-Heimbach.;Markus Nöthen.;Martin Ingelsson.;Caroline Graff.;Agustín Ruiz.;Jean-Charles Lambert.;Alfredo Ramirez.;Alexander J Eckardt.;Michaela Müller.;Michael Knapp.;Thaddäus T Wissinowski.;Jutta Keller.;Christiane Josephine Bruns.;Christian Gerges.;Horst Neuhaus.;Thomas Rösch.;Britta Siegmund.;Brigitte Schumacher.;Marino Venerito.;Antonio Ruiz de León.;Riccardo Rosati.;Vito Annese.;Uberto Fumagalli.;Luigi Laghi.;Elena Urcelay.;Fabienne Vavasseur.;Sabine Roman.;Pinghong Zhou.;Quanlin Li.;Zuqiang Liu.;Burkhard H A von Rahden.;Dimitris Theodorou.;Ewa Malecka-Wojciesko.;Carlo Maj.;Ana G Vigo.;Jan Martinek.;Guy Boeckxstaens.;Johannes Schumacher.
来源: Gut. 2025年75卷3期
Idiopathic achalasia (IA) is characterised by the degeneration of neurons in the myenteric plexus leading to an irreversible impaired oesophageal function. Although immune-mediated mechanisms have been proposed, the underlying aetiopathology of IA remains poorly understood.
193. SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL.
作者: Mi Zhang.;Chanyuan Chen.;Haifeng Zhang.;Tanqing Long.;Tingjie Wang.;Nanjin Ding.;Ruitao Long.;Hua Wu.;Zhilu Ma.;Zhongyu Cheng.;Junyan Tao.;Dong Kuang.;Lei Li.;Chuanrui Xu.
来源: Gut. 2025年
SIRT6 acts as a tumour suppressor in multiple cancers by regulating glucose and lipid metabolism, but its role in intrahepatic cholangiocarcinoma (ICC) remains unclear.
196. iPSC-induced multilineage liver organoids, small intestinal organoids and brain organoids sustain pangenotype hepatitis E virus propagation.
作者: Fan Liu.;Tianxu Liu.;Xi Wu.;Zihao Yu.;Jincheng Tong.;Lili Wang.;Chenyan Zhao.;Jianhui Nie.;Youchun Wang.;Kai Wang.;Lin Bai.;Pengyan Xia.;Kai Wang.;Guochao Wei.;Zi-Zheng Zheng.;Di Wu.;Weijin Huang.;Lin Wang.
来源: Gut. 2026年75卷4期787-800页
Hepatitis E virus (HEV), the leading global cause of acute viral hepatitis, lacks robust in vitro models for virology and pathogenesis research.
198. PDE5A+ cancer-associated fibroblasts enhance immune suppression in gastric cancer.
作者: Kewei Wang.;Chen-Jun Xie.;Zheng Ding.;Ting Shan.;Zhangfeng Zhong.;Feng-Lai Yuan.;Jun-Jie Wu.;Zheng-Dong Yuan.;Chengjia Qian.;Lihua Yu.;Yankui Liu.;Jianqing Cheng.;Qing-Lin Zhang.;Wei Liu.;Yong Zhao.;Jianfeng Huang.;Wen-Zhe Zhang.;Qian Yin.;Bo-Yu Gao.;Jie-Qing Hou.;Ji-Chao Wang.;Jie Mei.;Chao Deng.
来源: Gut. 2025年
Gastric cancer (GC) ranks among the most prevalent lethal tumours globally. Cancer-associated fibroblasts (CAFs) are pivotal in creating an immunosuppressive tumour microenvironment (TME) in GC.
199. SMYD2-mediated methylation of STAT1 protects against hepatic ischaemia/reperfusion injury by blocking JAK-STAT1 signalling pathways.
作者: Zhiyong Yang.;Yufeng Hu.;Chunyong Yang.;Yujie Li.;Xueyuan Zhong.;Zhenfu Wu.;Yingjie Zuo.;Shanyu Gan.;Lin Chen.;Ziyang Zeng.;Guiheng Qi.;Yuanbao Chen.;Junjie Zhou.;Xiao-Jing Zhang.;Hongliang Li.;Bin Yi.
来源: Gut. 2026年75卷2期326-340页
The JAK/STAT pathway plays a pivotal role in hepatic ischaemia/reperfusion (I/R) injury, a serious perioperative complication. Although signal transducers and activators of transcription 1 (STAT1) activation is known to drive I/R-induced injury, the specific post-translational modifications (PTMs) governing its activity in hepatic I/R remain poorly understood.
|