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1. [Role of the expression level of Nrf2 in predicting response of EGFR-TKIs in lung adenocarcinoma patients with EGFR gene mutations].
作者: Xiang Zhu.;Li Liang.;Chen Liu.;Wencheng Yin.;Sen Chen.;Baoshan Cao.
来源: Zhongguo Fei Ai Za Zhi. 2014年17卷2期155-62页
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have become first-line treatment drugs for lung adenocarcinoma patients with EGFR gene mutations. Significant interindividual variations in response rate, progression-free survival (PFS), and overall survival (OS) have been observed. The expression level of nuclear factor erythroid-2-related factor 2 (Nrf2) is related to chemoresistance against platinum drugs. Nrf2 overexpression can inhibit the sensitivity of EGFR-TKIs in cells with EGFR-sensitive mutations. The aim of this study is to investigate the protein expression level of Nrf2 in lung adenocarcinoma patients with EGFR gene mutations and to elucidate the correlation between Nrf2 expression and response rate of first-line EGFR-TKIs, as well as PFS and OS.
2. [Herbs for calming liver and suppressing yang in treatment of hyperthyroidism with hyperactive liver yang: herbal effects on lymphocyte protein expression].
作者: Xiangping Li.;Tao Yin.;Guangwei Zhong.;Wei Li.;Yanhong Luo.;Lingli Xiang.;Zhehao Liu.
来源: Zhongguo Zhong Yao Za Zhi. 2011年36卷14期1997-2004页
To observe the herbal effects on hyperthyroidism patients with syndrome of hyperactivity of liver-Yang by method for calming the liver and suppressing Yang and investigate its effects on the lymphocyte protein expression. This approach may lay a foundation for the further investigation of the curative mechanisms of calming the liver and suppressing Yang treatment.
3. [Preventive and therapeutic effect of E-leng capsule on post-operation recurrence of ovarian endometriotic cysts and its influence on expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in eutopic and ectopic endometrium].
To investigate the effect and mechanism of E-leng Capsule (ELC) in preventing and treating post-operation recurrence of ovarian endometriotic cysts (OEC).
4. [HER-2 expression in local advanced breast cancer and the efficacy of neoadjuvant chemotherapy regimens].
作者: Zhi-jun Dai.;Xi-jing Wang.;Zong-fang Li.;Hua-feng Kang.;Bao-shan Su.;Xiao-xu Liu.;Feng-jie Xue.;Xing-huan Xue.
来源: Nan Fang Yi Ke Da Xue Xue Bao. 2007年27卷9期1397-9页
To investigate the relationship between HER-2 expression and the efficacy of neoadjuvant chemotherapy in local advanced breast cancer.
5. [Inhibition of promyelocytic leukemia gene by tazarotene in hyperproliferative epidermis of psoriasis].
作者: Qiong-yu Wang.;Hu-ling Yan.;Ping Liu.;Zhen-hui Peng.;Sheng-shun Tan.
来源: Nan Fang Yi Ke Da Xue Xue Bao. 2006年26卷8期1146-8页
To investigate the mechanism of tazarotene against active psoriasis vulgaris.
6. [Comparison of therapeutic effects of low-dose versus high-dose interferon alpha-2b treatment on chronic myelocytic leukemia: a prospective randomized study].
作者: Jin-wei Du.;Ping Zhu.;Ding Tian.;Zuo-ren Dong.;Shu-lian Yang.;Song-bo Li.;Ya-hui Tang.;Hui Liu.;Xi-nan Cen.;Ying Zhang.;Qiang Zhu.;Yu-lin Zhu.;Ying Yang.;Dong-xia Wang.;Zhao Wang.;Hua Cui.;Yi-gai Ma.;Wen-ming Chen.;Fu-qiang Liu.;Jian Ma.;Jing-wen Wang.;Ti Shen.;Wan-ming Da.
来源: Zhonghua Yi Xue Za Zhi. 2005年85卷19期1305-9页
To compare the therapeutic effects of low-dose and high-dose interferon alpha-2b (IFN) treatment on chronic myelocytic leukemia (CML).
7. [Clinical study on reversal of multidrug resistance in refractory and relapsed acute leukemias by cyclosporin A].
To explore the clinical implication of reversal of multidrug resistance (MDR) by cyclosporin A (CsA) in refractory and relapsed acute leukemias.
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