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9901. [Significance of vascular endothelial growth factor expression in colorectal cancer].
To investigate the expression of vascular endothelial growth factor (VEGF) mRNA in colorectal cancer (CRC) and its relation with the clinicopathologic features and explore new approaches to prevent and inhibit recurrence and metastasis of CRC.
9902. [Effect of exogenous p16 gene on biological behaviors of human lung cancer].
To evaluate the biological effects of tumor suppressor gene p16 on human lung cancer cells with p16 gene deletion.
9903. [The effect of adenovirus-mediated wild-type p53 expression on the growth of human pancreatic carcinoma cell line cells].
To evaluate the effect of the wild-type p53(wtp53) expression on the growth of pancreatic carcinoma cell line.
9904. [Induction differentiation by a new third generation retinoid R9158 on human acute promyelocytic leukemia cell line, NB4].
In order to investigate the differentiation of 3',5'-ditertiary-butiary-4'-methoxy-carboxyl chalcone (R9158) on the acute promyelocytic leukemia NB4 cells.
9905. [Murine Doube Minute 2 oncogene inhibited apoptosis induced by retroviral-mediated wild-type p53].
To investigate the interaction between Murine Doube Minute 2 (MDM2) oncogene and p53 gene in the evolution of apoptosis in pancreatic carcinoma.
9906. [Expression of heat shock proteins in laryngeal carcinoma].
To determine the expression of HSPs(HSP90 alpha, HSP90 beta, HSP70, HSP27) in laryngeal carcinoma and normal laryngeal mucosa.
9907. [Analysis of Myc gene family in laryngeal cancer].
To study the abnormal amplification and role of Myc gene family in the development of laryngeal cancer.
9908. [Tumour suppressor p53 gene sequence mutations in pleomorphic adenoma of salivary gland].
To detect p53 exon 7 and 8 mutation and to study genesis and biological characteristics of pleomorphic adenoma of salivary galand.
9909. [Identification of cDNA fragments related to alpha particles radiation induced neoplastic transformation of rat tracheal epithelial cells].
To isolate genes involved in neoplastic transformation induced by alpha-particles.
9910. [Analysis of instability and deletion on chromosome 3p14 in Peutz-Jeghers syndrome].
To determine the region where the tumor susceptible genes located, and to study chromosome instability, deletion and rearrangement of genes in Peutz-Jeghers Syndrome.
9911. [Specific activity of the promoter containing Myc-Max response elements in c-myc-overexpressing cells].
To investigate the specific activity of a hybrid promoter which is constructed by replacing the third domain of herpes simplex virus (HSV) thymidine kinase (TK) promoter with the Myc-Max response elements.
9912. [Mutations of hMLH1 and hMSH2 genes in suspected hereditary nonpolyposis colorectal cancer].
To analyze the molecular characteristics of 29 ICG-HNPCC families and 34 suspected HNPCC families.
9913. [Expression of tumor metastasis suppressor gene KAI1/CD82 in human cancer cell lines with different metastasis potential].
To investigate the correlation of a newly-defined tumor metastasis suppressor gene KAI1/CD82 and metastatic potential of human cancer cell lines.
9914. [Expression of MAGE-1 gene in hepatocellular carcinoma].
To investigate the expression of MAGE-1 mRNA in human hepatocellular carcinoma (HCC) and to discuss the possibility of using MAGE-1 antigens as a new peptide vaccine for immunotherapy for HCC.
9915. [Loss of heterozygosity on chromosomes 17 and 16 in primary hepatocellular carcinomas].
38 cases of hepatocellular (HCC) carcinomas were studied to detect loss of heterozygosity(LOH) at specific areas on chromosome 17 and 16, the possible relations were discussed between LOH and HBV/HCV infection and clinic-pathology of HCC.
9916. [STK11 gene mutation in Chinese with PJS].
To understand the mutation characteristic of STK11 gene in Chinese with Peutz-Jeghers syndrome and establish the gene diagnosis of PJS.
9917. [FHIT gene is abnormal in Chinese lung cancers].
To determine whether the FHIT gene at 3p14.2 is abnormal in Chinese lung cancers.
9918. [N-actyltransferase2 polymorphism in recurrence of colorectal polyps and adenomas].
To observe the polymorphism of metabolizing enzyme N-actyltransferase 2 gene in populations with history of colorectal adenoma and polyp and to explore the relationship between NAT2 gene phenotype and colorectal cancer genetic susceptibility.
9919. [Significance of her2 oncogene expression in primary nasopharyngeal carcinoma].
To investigate the status of her2 oncogene at DNA level and the molecular mechanism of overexpression of her2 oncoprotein in part of patients with nasopharyngeal carcinoma (NPC).
9920. [Genescan analysis of the loss of heterozygosity on the long arm of chromosome 6 in non-small cell lung cancer].
作者: H Gao.;Q Wang.;B Q Wang.;C H Yan.;S F Wang.;B C Wang.;J Zhu.;C B Huang.;S B Fu.;P Li.
来源: Yi Chuan Xue Bao. 2001年28卷10期903-10页
To investigate if there are microsatellite loci in the long arm of chromosome 6 that have close relationship with non-small cell lung cancer, Multiple PCR approach was used to analyze the 36 loci in the long arm of chromosome 6. The PCR products were analyzed in PAGE and then the electrophoresis maps were analyzed with Genescan and Genotyper. There is different LOH frequency in different loci. The total frequency of LOH in 41 lung cancers was 78%(32/41), with the highest frequency of LOH was detected on the locus D6S302(75%). There are 14 loci which have LOH frequency more than 20% and the loci are mainly located in 2 regions: 6q16.3-q21 [6 loci D6S458 (21.43%), D6S1694 (26.92%), D6S1717 (35.71%), D6S1565 (40%), D6S302 (75%), D6S1706 (36.36%) and 6q26-q27 (5 loci D6S1550 (38.46%), D6S264 (20%), D6S1585 (25%), D6S446 (33.33%), D6S281 (30.77%)], There may be tumor suppressor genes located in the two regions, which have a close relationship with non-small cell lung cancer.
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