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9661. [A study on homozygous deletion, hypermethylation, mutation and expression of p16 gene in human breast cancer].
作者: S Guo.;S Liao.;Z Meng.;J Liu.;M Huang.;D Wang.;H Ding.
来源: Zhonghua Bing Li Xue Za Zhi. 1999年28卷2期105-8页
To investigate the homozygous deletion (HZD), hypermethylation and mutation of p16 gene in human breast cancer and the relationship between the structural alterations of p16 gene and its expression.
9662. [The detection of microsatellite instability in carcinoma and adenoma of large bowel and its significance].
作者: X Yan.;Y Chen.;F Liu.;Y Luo.;G He.;R Lu.;D Fang.
来源: Zhonghua Bing Li Xue Za Zhi. 1999年28卷2期97-100页
To explore the role of microsatellite instability (MSI) in colorectal carcinogenesis and the relationship between MSI, proliferation activity and prognosis.
9663. [Molecular cloning of hTRT catalytic domain and its expression in tumors].
To study the expression of hTRT gene in tumors and its significance in cancer diagnosis.
9664. [The mechanism of p16 gene inactivation in human bladder transitional cell carcinoma].
To figure out the mechanism of p16 gene inactivation in human bladder transitional cell carcinoma (BTCC).
9665. [Expression of transforming growth factor alpha and its relationship with HBV infection in hepatocellular carcinomas].
To assess the expression of TGF alpha in hepatocellular carcinoma and its relationship with HBV infection.
9666. [HBxAg enhanced p53 protein accumulation in hepatoma cells].
In order to determine the interaction between HBxAg and p53 protein and its role in hepatocarcinogenesis.
9667. [A preliminary study of loss of heterozygosity on chromosome 1p in primary hepatocellular carcinoma].
Ten (10) loci on chromosome 1p were analyzed to detect LOH in 38 cases of hepatocellular carcinomas (HCC) in order to locate the deletion area and the possible deleted tumor suppressor gene (TSG) in HCC.
9668. [Research on the oncogenesis of cervical epithelial cells co-induced by human papillomavirus and human cytomegalovirus].
The carcinogenesis of the human cervical carcinoma is known closely associated with human papillomavirus (HPV). The purpose of this article is to identify whether another sexually transmitted factor, human cytomegalovirus (HCMV) plays as a co-factor role in the carcinogenesis.
9669. [Study on the correlation between the expression of protein p53 at stage III nasopharyngeal carcinoma and its biological behavior, prognosis, p53 gene mutation and the expression of LMP-1].
To investigate p53 protein expression at stage III nasopharyngeal differentiated non-keratinizing squamous carcinoma (DNKSC) and their correlation with biological behavior and prognosis;the relationship between p53 protein expression and p53 gene mutation and LMP-1 protein expression at 58 cases of stage III DNKSC.
9670. [Detection and analysis of SYT-SSX fusion gene in synovial sarcoma].
作者: Z Xu.;T Yang.;B Wu.;H Zhong.;Z Yang.;B Zhou.;C Zhang.;J Zheng.
来源: Zhonghua Bing Li Xue Za Zhi. 2001年30卷6期431-3页
To demonstrate that a characteristic SYT-SSX fusion gene resulting from chromosomal translocation t (X; 18) (p11; q11) was detectable in archival paraffin-embedded synovial sarcoma tissues.
9671. [Detection of SYT-SSX fusion gene in paraffin-embedded tissues and its clinicopathologic significance for synovial sarcoma].
To investigate the feasibility of detecting SYT-SSX fusion gene in paraffin-embedded tissues and its diagnostic significance for synovial sarcoma (SS).
9672. [Analysis of loss of heterozygosity on chromosome 6 in human prostate carcinoma and prostatic intraepithelial neoplasia].
To detect the significance of loss of heterozygosity (LOH) on chromosome 6 in prostate carcinoma and high grade prostatic intraepithelial neoplasia (PIN).
9673. [A study of the correlation between p16 protein expression and DNA quantitative analysis in human gastric carcinoma cells].
To investigate p16 protein expression and its correlation with DNA quantity in gastric carcinoma (GC) cells.
9674. [The pathology and DNA quantitative study of renal clear cell carcinoma in children].
To investigate the pathological features of renal clear cell carcinoma (RCCC) in children and its relationship to the DNA content of cancer cells and DNA ploidy.
9675. [Relationship between genetic alterations and clinicopathological features in intrahepatic cholangiocarcinoma].
To evaluate the pedigree of genetic alterations during the tumorigenesis of intrahepatic cholangiocarcinoma (ICC) and their correlation with clinicopathological features by analysis of loss of heterozygosity (LOH) in 6 tumor suppressor genes (APC, MCC, DCC, OGG1, p53 and RB1) and point mutations in Ki-ras-2 oncogene.
9676. [Clinical significance of c-myc oncogene amplification in primary hepatocellular carcinoma by interphase fluorescence in situ hybridization].
To investigate the relationships between c-myc oncogene amplification in primary hepatocellular carcinoma (HCC) and its clinical prognosis.
9677. [The malignant potential of ovarian atypical endometriosis].
To investigate the malignant potential of ovarian atypical endometriosis and ovarian endometrioid adenocarcinoma.
9678. [Fine mapping of the loss of heterozygosity for chromosome 1pter-p36.11 in nasopharyngeal carcinoma].
To construct a detailed mapping of the Chromosome 1pter-p36.11 deleted region (63.4 cM) in nasopharyngeal carcinoma (NPC) by polymerase chain reaction-loss of heterozygosity (PCR-LOH) analysis for the further research of NPC-related gene(s).
9679. [DNA ploidy analysis and Ki-67 examination on renal neoplasms: investigation of degree of malignancy and biological behavior of small renal tumors].
To investigate the degree of malignancy and the biological behavior of small renal tumors and provide a pathological basis for clinicians in determination of further treatment and prognosis.
9680. [Mutations of APC and K-ras gene in aberrant crypt foci from human colon].
To analyze the mutations of K-ras and APC gene in normal colorectal mucosa, aberrant crypt foci (ACF), adenoma and colorectal carcinoma (CRC); To study the genetic alteration in ACF and its possibility of being a molecular marker of very early colon cancer and to explore the relationship of ACF and colorectal adenoma.
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