To investigate the role of lycium bararum polysaccharides (LBP) on angiotensin II (AngII)-induced senescence of human umbilical vein endothelial cells (HUVECs) and expressions of P53 and P16 and explore the mechanism of LBP against aging.

To observe the injury in rat primary cultured neurons induced by Abeta(1-40) and the protective effects of combination of ginseng and ginko extracts.

To investigate the influence of najanalgesin on glutamate-glial transporter 1(GLT-1) in spinal cord of rats after L5 spinal nerve ligation and transection (SNL), and explore the spinal analgesic mechanism of najanalgesin.

To investigate the effect of curcumol on the proliferation, apoptosis and the expression NF-κB in nasopharyngeal carcinoma cell line CNE-2.

To investigate the effect of estrogen on MMR gene expression in colon cancer cells COLO205.

To explore the effect of rapamycin (RPM) on the expression of B and T lymphocyte attenuate (BTLA) on human peripheral blood T lymphocytes, providing a experimental basis for application of RPM to organ transplantation and autoimmune diseases.

To investigate the effects of high glucose and 5-aza-2'-deoxycytidine (5-aza-dCyd), a selective DNA methyltransferase inhibitor, on CTGF expression and methylation levels in human glomerular mesangial cells (HMCs).

To observe the influence of tanshinone II A on the expression of toll like receptor 4(TLR4) and tumor necrosis factor-α(TNF-α) in cultured human umbilical veins endothelial cells EA.hy926 induced by LPS, and to investigate the molecular mechanism of tanshinone II A against atherosclerosis(AS).

To investigate the effects of andrographolide on the concentration of TNF-α and TGF-β1 in bronchoalveolar lavage fluid (BALF) and the expressions of type I and III collagen mRNA in Lung tissue in bleomycin (BLM)-induced pulmonary fibrosis in rats.

In order to investigate the roles of metalloproteinase in inflammatory bone destruction in ankylosing spondylitis (AS), and analyze the mechanism of preventing inflammatory bone destruction of Bushen Qiangdu decoction (BSQDD) in AS cases. Comparisons were made on the expressions of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) by peripheral blood mononuclear cells (PBMC) between AS patients and healthy controls. The effect of BSQDD was investigated on the expression and of MMP-9 and TIMP-1 produced by PBMC in AS patients.

To compare the cytotoxicity of RAW264.7 cells induced by two types of multi-walled carbon nanotubes (MWCNTs) with different surface modifications (MWCNTs modified by taurine and MWCNTs treated by acid), and explore the role of endoplasmic reticulum (ER) in MWCNTs-induced apoptosis.

To investigate the relation between the effect of ginsenoside Rg1 to delay hematopoietic stem cell senescence and the expression of p16(INK4a). The purpose is to provide the theory and experimental foundation for searching the methods of how to delay HSC senescence.

Hsp90 is a major molecular chaperone, which overexpression is involved in oncogenesis, development and drug resistance in many human cancers. The aim of this study is to investigate the relationship between the GGA-induced overexpression of Hsp90 and chemoresistance to Cisplatin in SPCA-1 and H446 cell line.

Our previous in vivo experiment (paper has been published) has confirmed Feiyanning's regulation effect on epithelial cell markers Alpha-catenin, beta-catenin, E-Cadherin and mesenchymal cell markers N-cadherin, Fibronectin, vimentin. Based on previous study, the objective of this study is to further investigate the expression of epithelial-mesenchymal cell marker gene and protein intervened by Feiyanning in highly metastatic lung cancer cells 95-D in vitro.

To study the function of the chalcone synthese gene introns in Scutellaria baicalensis, and clarify preliminarily their role in abiotic stress.

It has been proven that chemotherapy combined with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) could not increase response for advanced non-small cell lung cancer (NSCLC), but its cellular mechanism was not well known. The aim of this study is to assess the effects of sequential administration of docetaxel and gefitinib on the cell proliferation and signal pathway of lung adenocarcinoma cell SPC-A1 and its cellular mechanism.

A DNA segment with DNA methylation site was detected from rice callus with or without 5-azaC treatment by MSAP. This segment was located on the first exon of gene OsMAPK2 and its 5' non-coding region. Gene OsMAPK2 had a CpG island in the 5' region and was homologous to AtMAPK12. Real-time quantitative PCR and Hpa II-McrBC PCR were conducted to detect the gene expression and DNA methylation of OsMAPK2 in the process of callus formation. The results showed that the DNA methylation was able to control the expression of OsMAPK2. The additon of 2.0 mg/L 2,4-D could induce DNA demethylation in the 5' region and activate the expression of OsMAPK2 gene. However, after long-time stimulation (100 h), the gene was methylated again, and the gene expression level was decreased. The trends of DNA methylation and gene expression stimulated by low concentrations of 2,4-D (0.5 and 1.0 mg/L) were similar to 2.0 mg/L 2,4-D, but the expression levels in each time point were low. On the other hand, high concentration of 2,4-D (5.0 mg/L) completed the processes of induction and suppression of the gene in a shorter time.

It has been proven that ribonucleotide reductase M1 (RRM1) expression level was closely related to gemcitabine drug-resistance to tumor cells. The aim of this study is to explore the relations between RRM1 protein expression levels and effects of gemcitabine and cisplatin chemotherapy in advanced non-small cell lung cancer (NSCLC) patients.

It has been proven that Src played pivotal roles in carcinogenesis, cancer progression and metastasis. The aim of this study is to explore the roles of Src phosphorylation on lung cancer cells.