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3921. [Transferring of mdr1 gene into murine bone marrow cells and its protective effects on hematopoietic cells against toxicities of anticancer agent].
To investigate the protective effects of mdr1 gene on hematopoietic cells against anticancer agents and to explore an effective approach to prevent myelosuppression due to chemotherapy.
3922. [Chemoprotection of transfer of multidrug resistance gene into human hematopoietic progenitor cell].
To observe the effect of the transfer of multidrug resistance gene (mdr1) into human hematopoietic progenitor cells (HPC) on the chemoprotection.
3923. [Potentiation of arsenic trioxide-induced apoptosis by retinoic acid in retinoic acid sensitive and resistant HL-60 myeloid leukemia cells].
To study the effect of arsenic trioxide (As2O3) on non-APL acute myeloid leukemia (AML) cells and the interreactive effect between retinoic acid (RA) and As2O3.
3924. [Expression of multidrug resistance-associated protein gene in non-small cell lung cancer].
To study the relationship between expression of multidrug resistance-associated protein (MRP) gene and occurrence of multidrug resistance (MDR) in non-small cell lung cancer (NSCLC).
3925. [The inhibiting effect of glycyrrhizin on proliferation of the mice submandibular gland fibrosarcoma cell line in vitro].
To study the inhibiting effect of glycyrrhizin on proliferation of the cell line of mice submandibular gland fibrosarcome in vitro.
3926. [The research of pancadherin and beta-catenin expression in pulmonary tissue of mice with bleomycin-induced pulmonary fibrosis].
To investigate the changes of pancadherin(Pan-cd) and beta-catenin(beta-cat) expression in pulmonary tissue of mice with bleomycin (BLM)-induced pulmonary injury and explore the relation between the Pan-cd/beta-cat expression and pulmonary fibrosis.
3927. [Antisense oligodeoxynucleotide of telomerase gene enhances cisplatin-induced apoptosis in acute myeloid leukemia and chronic myeloid leukemia cells].
To explore the effect of human telomerase reverse transcriptase(hTERT) gene antisense oligodeoxynucleotide (ASODN) on cisplatin-induced apoptosis in cultured primary acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) cells.
3928. [Inhibition effects of octreotide on the growth of hepatocellular carcinoma in vitro and in vivo].
To investigate the effects of somatostatin analogue octreotide on the proliferation and apoptosis of human hepatocellular carcinoma (HCC) cell line as well as the growth of HCC xenografts in nude mice.
3929. [Experimental study on resistance to cisplatin and taxol in human ovarian cancer SKOV3ip1 multicellular aggregates].
To investigate the chemosensitivity of ovarian cancer SKOV3ip1 multicellular aggregates to cisplatin and taxol and to explore the possible mechanisms accounting for the effect.
3930. [Influence of suppressor gene p16 on retinoic acid inducing lung cancer cell A549 differentiation].
To investigate the role of suppressor gene p16 in the process of differential regulation of retinoic acid (RA) on the A549 lung cancer cells.
3931. [mRNA expression of matrix metalloproteinase-2 and membrane type matrix metalloproteinase in pulmonary fibroblasts and macrophages of rat pulmonary fibrosis model].
To study the changes and significance of MMP-2 and MT1-MMP mRNA expressions in fibroblasts and macrophages of rat pulmonary fibrosis model.
3932. [Saikosaponin-d up-regulates GR mRNA expression and induces apoptosis in HL-60 cells].
To research the effect of saikosaponin-d (SSd) on the expression of glucocorticoid receptor (GR) mRNA and induction of apoptosis in HL-60 cells.
3933. [Effects of all-trans retinoic acid, arsenic trioxide and daunorubicin on tissue factor expression in NB4 cells].
To investigate the effects of all-trans retinoic acid(ATRA), arsenic trioxide(As2O3) and daunorubicin(DNR) on tissue factor(TF) expression in acute promyelocytic leukemia (APL) cell line NB4 cells.
3934. [Effects of As2O3 on the BCR/ABL protein tyrosine phosphorylation in K562 cells].
To explore the mechanisms of As2O3 inducing apoptosis and growth inhibition in K562 cells and provide theoretical basis for clinical application.
3935. [Induction differentiation by a new third generation retinoid R9158 on human acute promyelocytic leukemia cell line, NB4].
In order to investigate the differentiation of 3',5'-ditertiary-butiary-4'-methoxy-carboxyl chalcone (R9158) on the acute promyelocytic leukemia NB4 cells.
3936. [Dynamic change of intracellular-free calcium levels and its mechanism in the process of gastric carcinoma cellular apoptosis].
To study the dynamic change of intracellular-free calcium levels ([Ca2+]i) and its mechanism in the process of gastric carcinoma cellular apoptosis.
3937. [Inhibition of tumor invasion by new retinoid, 5-4A, and its mechanism of the action].
To investigate the effect of 5-4A on the invasion of B16BL6 and to explore its mechanisms of action.
3938. [Trends in the pharmaceutical research of ribonucleases and their therapeutic uses].
As one of the most popular model enzymes, the structure and evolution of ribonucleases (RNases) have been studied thoroughly. But until recently, scientists found out that RNases demonstrated a series of important biological functions, such as controlling blood vessel formation, killing tumor cells and inhibiting virus. Now immunotoxin, the antibody-toxin conjugate, becomes a research hot spot. RNases with cytotoxicity are the candidates for the toxin moiety of the immunotoxins. In this paper, the newly found cytotoxic functions of RNases are discussed in detail.
3939. [The effect of p53 gene on p-glycoprotein expression and chemotherapeutic cytotoxicity of hepatocellular carcinoma].
To test the hypothesis that wild-type p53 regulates the expression of p-glycoprotein.
3940. [In vitro study on cellular and molecular mechanism of tripterine treating leukemic mast cells].
To explore the effect of tripterine on leukemic mast cells.
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