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3861. [Effects of all-trans retinoic acid and arsenic trioxide on tissue factor expression of acute promyelocytic leukemia cells].
To investigate the effects of all-trans retinoic acid (ATRA) and arsenic trioxide (As(2)O(3)) on both tissue factor (TF) expression and procoagulant activity (PCA) of acute promyelocytic leukemia (APL) cells in vivo and in vitro.
3862. [Effects of arsenic trioxide on K562 cells stably expressing two promyelocytic leukemia-specific fusion proteins].
To illustrate the possible roles of acute promyelocytic leukemia-specific chimeric proteins PML-RARalpha and PLZF-RARalpha in the effects of arsenic trioxide (As(2)O(3)).
3863. [Effect of radiotherapy on penetration of 5-FU in blood-pancreatic barrier in rats].
To investigate the effect of radiotherapy dose on penetration of 5-FU (5-fluorouracil) in blood-pancreatic barrier in rats.
3864. [Experimental study on human pancreatic carcinoma treated by cytosine deaminase gene therapy].
To explore the possibility of Escherichia coli cytosine deaminase (CD) gene on human pancreatic carcinoma gene therapy.
3865. [The effects of taxol on different types of lymphoma cell lines].
To observe the effects of new anticancer drug taxol on different types of lymphoma cells and to explore the value of its clinical application.
3866. [Reversal of multidrug resistance of leukemia cell line in vitro by antisense phosphorothioate oligonucleotide].
To investigate the effectiveness of 14 mer antisense phosphorothioate oligonucleotide (AS-SODN) complementary to the published multidrug resistance gene (mdr(1) gene) sequence to reverse multidrug resistance of leukemia cell line.
3867. [An analysis of the therapeutic effects and reactions in treating acute promyelocytic leukemia with intravenous arsenic trioxide or all-trans retinoic acid].
To compare the therapeutic effects and reactions of intra venous arsenic trioxide and all-trans retinoic acid in treating patients with acute promyelocytic leukemia (APL).
3868. [Expression and purification of murine interleukin 18 in Escherichia coli and its antitumor effects].
Total RNA was extracted from murine hepatocytes, and the cDNA of interleukin 18(IL-18) was amplified by RT-PCR. The cDNA was introduced into the expression vector pJW2 and sequenced. Under heat induction, the recombinant murine IL-18(rmIL-18) was expressed in inclusion bodies in E. coli with the yield accounting for 18% of total bacteria proteins. The inclusion bodies were dissolved with 5 mol/L urea, and rmIL-18 was purified using Sephadex G-100 column chromatography. In the presence of 0.5 mg/L Con A, the purified rmIL-18 showed dose-dependent IFN-gamma-inducing activity in murine splenocytes. The purified rmIL-18 exhibited significant antitumor effects in Kunming mice challenged intraperitoneally (i.p.) with H22 hepatocarcinoma when administered 10 micrograms rmIL-18 i.p. on days 1, 4 after challenge, and the mice survived resisted the rechallenged with H22 cells.
3869. [Study on role of metallothionein in anticancer effect of copper green on treatment of experimental hepatocarcinoma in mice].
To study the role of metallothionein (MT) in the anticancer effect of copper green on experimental hepatoma (H22) in mice.
3870. [The effect of tamoxifen of endometrium].
To evaluate the effect of tamoxifen on the endometrium.
3871. [Study on 515 anti-tumor recipe in inducing leukemic HL-60 cells apoptosis].
To observe the efficacy of 515 anti-tumor recipe on inducing human myeloid leukemic HL-60 cells apoptosis.
3872. [Effect of Chinese herbal medicine on immuno-inhibition caused by chemotherapy and radiotherapy].3873. [Research on biotherapeuticeffect anticancerous remedies].3874. [Experimental study on anti-cancer effect of Cantharidine derivatives and platinum complex].
To certify the anti-tumor effects of the four Cantharidine derivatives and platinum complex on transplanted tumor in mice to search for new anti-tumor drugs.
3875. [Potentiated effects of total saponins of Panax Ginseng on inhibition of leukemic cells by cytotoxic drugs].
To investigate the potentiated effects of total saponins of Panax Ginseng (TSPG) on inhibition of leukemic progenitor cells by cytotoxic drugs in acute myelocytic leukemia.
3876. [Experimental study on apoptosis induced by ursolic acid isolated from asparagus in HL-60 cells].
To study the inhibitory effect of ursolic acid isolated from Asparagus on the proliferation of HL-60 cells.
3877. [Study on preventive and therapeutic effect of radix salviae miltiorrhizae on recurrence and metastasis of liver cancer].
To study the inhibitory effect of Radix Salviae Miltiorrhizae (RSM) on adhesive and invasive ability of SMMC-7721 liver cancer cells, and on the metastasis and recurrence on post-hepatectomy liver cancer in nude mice.
3878. [Cell differentiation and apoptosis of tumor cells].3879. [Review on experimental studies of Chinese drugs in antagonizing bone marrow inhibition caused by chemicals].3880. [Ailing No. I in treating 62 cases of acute promyelocytic leukemia].
To obtain further knowledge on the effect, mechanism and toxic side-effect of Ailing No. I (AL), a preparation of As2O3, in treating acute promyelocytic leukemia (APL).
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