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3821. [Effect of inhibition of telomerase activity on cisplatin-induced apoptosis in K562 cells].
To explore the effect of human telomerase reverse transcriptase (hTERT) gene antisense oligodeoxynucleotide (ASODN) on telomerase activity and cisplatin-induced apoptosis in K562 cells.
3822. [Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3].
To study the variation and significance of caspase 3 activity in the process of amino-peptidase inhibitor--bestatin (BS) inducing human leukemic cell apoptosis.
3823. [In vitro cotransfer human multidrug resistance gene (mdr-1) and dihydrofolate reductase gene (DHFR) into human CD(34)(+) progenitor cells to broaden the spectrum of drug resistance].
To explore the feasibility of cotransferring human mdr-1 gene and DHFR gene into human CD(34)(+) progenitor cells to broaden the spectrum of drug resistance and improve the tolerance of myelosuppression following combination chemotherapy.
3824. [Study on the relationship between apoptosis and reactive oxygen species of cancer cell lines induced by anticarcinogens].
作者: L Cai.;S Gao.;Y Yang.;D Zheng.;W Wang.;G Zhang.;Q Fuyong.
来源: Zhonghua Xue Ye Xue Za Zhi. 2001年22卷5期249-51页
To investigate the relationship between apoptosis (AP) and fluorescent intensity of reactive oxygen species (ROS) in cancer cell lines induced by anticancer agents, and the mechanisms of drug sensitivity and resistance.
3825. [Inhibition of proliferation and induction of apoptosis by simvastatin in K562 leukemic cell line].
To investigate the anti-apoptotic mechanism and explore approach to inhibiting proliferation and inducing apoptosis of chronic myclogenous leukemia (CML) cells.
3826. [Protection of hematopoietic stem cells by MIP-1alpha and PF4 against the cytotoxicity of chemotherapeutic agents].
To study the protective effects of macrophage inflammatory protein-1alpha (MIP-1alpha) and platelet factor 4 (PF4), alone and in combination, on hematopoietic stem/progenitor cells against the cytotoxicity of chemotherapeutic drugs.
3827. [Altered subcellular distribution of daunorubicin in the non-P-glycoprotein-mediated multidrug-resistant cell line HL-60/ADR].
作者: Y Gong.;Y Wang.;F Chen.;J Han.;N Shao.;Z Fang.;R Ouyang.
来源: Zhonghua Xue Ye Xue Za Zhi. 2000年21卷6期309-11, 2页
To investigate DNR subcellular distribution in the non-P-glycoprotein-mediated multidrug-resistant cell line HL-60/ADR and its relation to multidrug resistance.
3828. [Taxol-induced apoptosis in Jurkat T cell lymphoma cell line and its molecular mechanisms].
作者: X Zhou.;L Xu.;K He.;T Zhang.;W Zhu.;X Li.;A Jin.
来源: Zhonghua Xue Ye Xue Za Zhi. 2000年21卷6期298-300页
To observe whether antimicrotubular drug taxol can induce apoptosis in Jurkat T cell lymphoma cell line and the role of bcl-2 gene family in this process.
3829. [Mobilization of autologous peripheral blood stem cells by chemotherapy and recombinant granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF)].
作者: X Cui.;Y Shao.;B Ren.;Z Tong.;X Ren.;L Li.;Z Zhang.;N Zhang.;R Dai.;X Hao.
来源: Zhonghua Xue Ye Xue Za Zhi. 2000年21卷5期247-9页
To observe the efficacy of chemotherapy and recombinant granulocyte colony-stimulating factor (G-CSF, Glycosylated) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in autologous peripheral blood stem cells (APBSC) mobilization.
3830. [Mechanism of tissue factor expression on NB4 cells down-regulated by all-trans retinoic acid and arsenic trioxide].
作者: W Guo.;H Wang.;W Zhao.;B Qu.;L Pan.;J Zhu.;H Chu.;X Wang.
来源: Zhonghua Xue Ye Xue Za Zhi. 2000年21卷5期240-3页
To investigate molecular mechanism of tissue factor (TF) expression on acute promyelocytic leukemia cell line NB4 cells down-regulated by all-trans retinoic acid (ATRA) and arsenic trioxide (As(2)O(3)).
3831. [Effects of p21WAF1/CIP1 gene introduction on a human lung cancer cell line with p53 mutation].
作者: Y Zhuo.;B Zhang.;T Li.;H Wang.;S Li.;L Hou.;B Wu.
来源: Zhonghua Bing Li Xue Za Zhi. 1999年28卷4期272-6页
To study the effects of p21WAF1/CIP1 gene expression on the biological hehavior of cancer cells with p53 gene mutation.
3832. [Morphological changes of mitochondria in apoptosis of esophageal carcinoma cells induced by As(2)O(3)].
In order to make clear how As(2)O(3) targets the cells of esophageal carcinoma, the morphology of mitochondria and expression of bcl-2/bax were selected to study the SHEEC1 cell line during early apoptosis.
3833. [Induction of quinone reductase and glutathion-s-transferase by dimethyl fumarate in rats].
To assess induction of quinone reductase (QR) and glutathion-s-transferases (GSTs) by dimethyl fumarate (DMF) in major viscera of rats.
3834. [Studies on apoptosis of human lung adenocarcinoma cells induced by oltipraz].
To study whether oltipraz can induce apoptosis of human lung adenocarcinoma (GLC-82) cells and its possible mechanism.
3835. [Protection against synergistic hepatocarcinogenesis of hepatitis B virus expression and aflatoxin B1 by antioxidant 2(3)-tert-4 -hydroxyanisole (BHA) in HBV large envelope transgenic mice].
To investigate the effects of 2(3)-tert-4-hydroxyanisole (BHA) on protection against synergistic hepatocarcinogenesis of aflatoxin B(1) (AFB(1)) and hepatitis B virus (HBV) expression in HBV large envelope transgenic mice.
3836. [Influence on tear film of postoperative 5-fluourouracil and intraoperative mitomycin C in glaucoma filtration surgery].
To investigate the changes of tear film functions due to the use of postoperative 5-fluourouracil (5-Fu) and intraoperative mitomycin C (MMC) in glaucoma filtration surgery.
3837. [The inhibitory effect of CLA on mice forestomach neoplasia induced by B(a)P].
To study the inhibitory effect of CLA on the postinitiation phase of forestomach neoplasia formation induced by B(a)P and explore its possible mechanism of anticarcinogenesis.
3838. [Single topotecan or in combination with other chemotherapeutic agents for 18 recurrent advanced ovarian cancer patients].
This study was designed to evaluate the efficacy and toxicity of topotecan hydrochloride, used singly or combined with other drugs in patients with recurrent advanced ovarian cancer.
3839. [Implanted percutaneous continuous hepatic arterial infusion system for nonresectable liver metastasis].
To evaluate the efficacy of continuous hepatic arterial infusion of 5-fluorouracil (5-Fu)/calcium folinate (CF) through an implanted percutaneous arterial infusion system for nonresectable liver metastasis.
3840. [Arsenic trioxide in the treatment of advanced primary liver and gallbladder cancer].
To evaluate the effect and toxicity of arsenic trioxide (As2O3) in treating primary liver and gallbladder cancer.
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