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3581. [Bcl-2 antisense oligodeoxyribonucleotide increases apoptosis of lung carcinoma cells induced by cisplatin].
To study the effect of antisense oligodeoxyribonucleotide (ODN) to apoptotic suppress gene bcl-2 on apoptosis of lung carcinoma cells induced by cisplatin.
3582. [Functional status of p53 and chemosensitivity of colon cancer cell lines].
To study the functional status of tumor suppressor gene p53 in relation to chemotherapeutic sensitivity in colon cancer cell lines.
3583. [Development of drug resistance and alteration of cell cycle in lung cancer: a flow cytometric study].
To study the relationship between the expression of multidrug resistance-associated protein (MRP) and P-glycoprotein (P-gp) and alteration of cell cycle during the process of drug resistance in lung cancer.
3584. [Genistein exerts multiple suppressive effects on human breast carcinoma cells].
To study the suppressive effects of genistein on progression of breast carcinoma.
3585. [The mechanism of docetaxel-induced apoptosis in human lung cancer cells].
To study the mechanism of docetaxel-induced apoptosis.
3586. [Modulating effect of vitamin D3 in vitro on EGFR mRNA expression of human breast cancer cell lines].
To assess the modulating effects of vitamin D3, combined with or without tamoxifen, on cell proliferation and EGFR mRNA level of human breast cancer.
3587. [Mechanism of retinoic acid receptor alpha-mediated growth inhibition of gastric cancer cells by all-trans retinoic acid].
To study the mechanism of retinoic acid receptor alpha(RAR alpha) in mediating growth inhibition of gastric cancer cells by all-trans retinoic acid(ATRA).
3588. [Reversion of multidrug resistance in vitro of lung adenocarcinoma by mdr1 ribozyme].
To investigate the possibility of reversion of multidrug resistant (MDR) in lung adenocarcinoma-resistant cell line A549/R by mdr1 ribozyme.
3589. [Establishment and biological characteristics of vincristine: resistant cell line from human squamous cell carcinoma].
To establish a VCR-resistant cell line from human squamous cell carcinoma.
3590. [Protective effect of mutant dihydrofolate reductase gene on human peripheral blood CD34+ cells against methotrexate].
To examine if human peripheral blood hematopoietic progenitor cells transduced with mutant dihydrofolate reductase(mDHFR) gene may increase their resistance to metrotrexate(MTX).
3591. [Protein tyrosine kinase inhibitor genistein suppresses in vitro invasion of HT1080 human fibrosarcoma cells].
To investigate the effects of genistein on cancer invasion and associated cellular characteristics and explore the possibility of developing protein tyrosine kinase inhibitors as anti-metastasis drugs.
3592. [Changes in [Ca2+]i and IP3 levels in the process of cisplatin-induced apoptosis of gastric carcinoma].
To study the change and significance of intracellular-free calcium levels ([Ca2+]i) and inositol 1, 4, 5-trisphosphate (IP3) levels in the process of gastric carcinoma cell apoptosis induced by cisplatin.
3593. [Clinical observation of taxotere in the treatment of advanced non-small-cell lung cancer and breast cancer].
To observe the response rate and toxic reaction of taxotere in the treatment of advanced NSCLC and breast cancer.
3594. [Drug resistance of acute promyelocytic leukemia (APL) to all-trans retinoic acid (ATRA) and its reversion].
To study the mechanism of drug resistance of APL to ATRA and the methods of reversion.
3595. [In vitro study of radiation sensitizing effect of hydroxycamptothecin].
To study the radiation sensitizing effect of hydroxycamptothecin (HCPT) on human stomach adenocacinoma and nasopharyngeal carcinoma.
3596. [Difluoromethylornithine synergizes with antisense bcl-2 RNA in the induction of apoptosis of HL60 cells].
To study the combined effect of difluoromethylornithine (DFMO) and bcl-2 antisense RNA in the induction of apoptosis of HL60 cells.
3597. [Preliminary study on the antitumor immuno-protective mechanism of beta-elemene].
To study the antitumor effects and their molecular mechanism of beta-elemene, which is one of the effective monomers of Oleum Curcuma aromatica, a Chinese anticancer medicament.
3598. [Effect of tamoxifen on apoptosis and drug resistance of breast cancer cells in vitro].
To study the effect of estradiol (E2) and tamoxifen (TAM) on the apoptosis regulatory genes (bax, bcl-2) and mdr-1 in MCF-7 cells.
3599. [Cloning and antitumor activity of angiogenesis inhibitor HIAF-1].
A new angiogenesis inhibitor HIAF-1 (human inhibitor angiogenesis factor-1) was cloned, expressed in E. coli and its antitumor activity was studied.
3600. [The effect of antisense hsp90 beta on the malignant phenotype and sensitivity of HeLa cells to chemotherapeutic drugs].
To study the effects of hsp90 beta on tumorigenesis and sensitivity of HeLa cells to chemotherapeutic drugs.
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