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3541. [Pharmacokinetics of adriamycin by bronchial artery infusion for non-small cell bronchogenic carcinoma].
This pharmacokinetic study was conducted to determine the plasma concentration of adriamycin after bronchial artery infusion (BAI), and to compare it with the conventional chemotherapy.
3542. [Modulation of human small cell lung cancer cell line GLC4/ADR multidrug resistance in the inhibition of multidrug resistance-associated protein and its antisense].
To study the effect of antisense multidrug resistance-associated protein (MRP) RNA on multidrug resistance (MDR) in the human small cell lung cancer (SCLC) cell line GLC4/ADR, in which the overexpression of MRP gene is discovered.
3543. [Synergistic efficacy of adenovirus-mediated bcl-Xs gene therapy and cisplatin in ovarian cancer cell].
To observe the presence of synergistic efficacy between adenovirus-mediated bcl-Xs (Adv-bcl-Xs) gene therapy and cisplatin (CDDP) in ovarian cancer cell.
3544. [Summarization of studies on Chinese marine medicinal animal Syngnthus acus].
Syngnthus acus L. is a kind of very important traditional Chinese-medicine from sea. It has plentiful amino acid, protein, trace element, poly-carbon non-saturation fat acid, etc. Syngnthus acus has sexual-hormones-like, anti-cancer and resisting fatigue effects; It can resist fatigue. It can also improve organism immunity and enhance the systolic strength of heart muscle. It can be widely used in many fields such as food field, medical field and aquatic products industry. Its classification, resources, chemical composition and its medical value have been summarized in this article.
3545. [Study on active constituents of traditional Chinese medicine reversing multidrug resistance of tumor cells in vitro].
To screen drugs reversing multidrug resistance of tumor cells from active constituents of traditional Chinese medicine and to study the reversal action.
3546. [The selection of taxol resistance associated genes in ovarian cancer cell line by mRNA DD].
One of the main reasons of the treatment failure for ovarian cancer is the emergence of drug resistance in which several genes involved. The purpose of the study was to select the genes related to Taxol resistance in ovarian cancer.
3547. [Effects of all-trans retinoic acid and arsenic trioxide on tissue factor expression of acute promyelocytic leukemia cells].
To investigate the effects of all-trans retinoic acid (ATRA) and arsenic trioxide (As(2)O(3)) on both tissue factor (TF) expression and procoagulant activity (PCA) of acute promyelocytic leukemia (APL) cells in vivo and in vitro.
3548. [Effects of arsenic trioxide on K562 cells stably expressing two promyelocytic leukemia-specific fusion proteins].
To illustrate the possible roles of acute promyelocytic leukemia-specific chimeric proteins PML-RARalpha and PLZF-RARalpha in the effects of arsenic trioxide (As(2)O(3)).
3549. [Experimental study on human pancreatic carcinoma treated by cytosine deaminase gene therapy].
To explore the possibility of Escherichia coli cytosine deaminase (CD) gene on human pancreatic carcinoma gene therapy.
3550. [The effects of taxol on different types of lymphoma cell lines].
To observe the effects of new anticancer drug taxol on different types of lymphoma cells and to explore the value of its clinical application.
3551. [Reversal of multidrug resistance of leukemia cell line in vitro by antisense phosphorothioate oligonucleotide].
To investigate the effectiveness of 14 mer antisense phosphorothioate oligonucleotide (AS-SODN) complementary to the published multidrug resistance gene (mdr(1) gene) sequence to reverse multidrug resistance of leukemia cell line.
3552. [An analysis of the therapeutic effects and reactions in treating acute promyelocytic leukemia with intravenous arsenic trioxide or all-trans retinoic acid].
To compare the therapeutic effects and reactions of intra venous arsenic trioxide and all-trans retinoic acid in treating patients with acute promyelocytic leukemia (APL).
3553. [Expression and purification of murine interleukin 18 in Escherichia coli and its antitumor effects].
Total RNA was extracted from murine hepatocytes, and the cDNA of interleukin 18(IL-18) was amplified by RT-PCR. The cDNA was introduced into the expression vector pJW2 and sequenced. Under heat induction, the recombinant murine IL-18(rmIL-18) was expressed in inclusion bodies in E. coli with the yield accounting for 18% of total bacteria proteins. The inclusion bodies were dissolved with 5 mol/L urea, and rmIL-18 was purified using Sephadex G-100 column chromatography. In the presence of 0.5 mg/L Con A, the purified rmIL-18 showed dose-dependent IFN-gamma-inducing activity in murine splenocytes. The purified rmIL-18 exhibited significant antitumor effects in Kunming mice challenged intraperitoneally (i.p.) with H22 hepatocarcinoma when administered 10 micrograms rmIL-18 i.p. on days 1, 4 after challenge, and the mice survived resisted the rechallenged with H22 cells.
3554. [Study on role of metallothionein in anticancer effect of copper green on treatment of experimental hepatocarcinoma in mice].
To study the role of metallothionein (MT) in the anticancer effect of copper green on experimental hepatoma (H22) in mice.
3555. [The effect of tamoxifen of endometrium].
To evaluate the effect of tamoxifen on the endometrium.
3556. [Study on 515 anti-tumor recipe in inducing leukemic HL-60 cells apoptosis].
To observe the efficacy of 515 anti-tumor recipe on inducing human myeloid leukemic HL-60 cells apoptosis.
3557. [Effect of Chinese herbal medicine on immuno-inhibition caused by chemotherapy and radiotherapy].3558. [Research on biotherapeuticeffect anticancerous remedies].3559. [Experimental study on anti-cancer effect of Cantharidine derivatives and platinum complex].
To certify the anti-tumor effects of the four Cantharidine derivatives and platinum complex on transplanted tumor in mice to search for new anti-tumor drugs.
3560. [Potentiated effects of total saponins of Panax Ginseng on inhibition of leukemic cells by cytotoxic drugs].
To investigate the potentiated effects of total saponins of Panax Ginseng (TSPG) on inhibition of leukemic progenitor cells by cytotoxic drugs in acute myelocytic leukemia.
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