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321. [Quercetin regulates cell cycle-related gene expression in a model of glucose-oxygen deprivation in astrocytes].
作者: Fang Yao.;Lanlan Zhang.;Zhaohu Yuan.;Yong Zeng.;Bingyi Wu.
来源: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013年29卷9期910-3页
To study the effect of quercetin on gene expression in astrocytes after glucose-oxygen deprivation and the underlying mechanism.
322. [Effect of Panax notoginseng saponins on expressions of MMP-13 and TIMP-1 in rats with hepatic fibrosis].
作者: Hui Jiang.;Lun-Zhu Xia.;Ying Li.;Xiang Li.;Jian Wu.
来源: Zhongguo Zhong Yao Za Zhi. 2013年38卷8期1206-10页
To investigate the effect of Panax notoginseng saponins (PNS) on the expressions of matrix metalloproteinase (MMP)-13 and its tissue inhibitor of metalloproteinase (TIMP)-1 in carbon tetrachloride (CCl4)-induced hepatic fibrosis rats, and explore the possible mechanism of PNS's effect against hepatic fibrosis.
323. [Advances on effects of triptolide with non-small cell lung cancer].
Triptolide can cure a variety kinds of non-small cell lung cancer cell lines. It can interfere the cell cycle, active the caspase signaling pathway, inhibit the of expression vascular endothelial growth factor (VEGF), inhibit the activation of NF-κB, and through these ways to promote lung cancer cell death. Now the anti-tumor mechanism and effect of triptolide was summarized to provide help for scientific research and clinical applications in non-small cell lung cancer.
324. [Role of autophagy on cobrotoxin induced cell death of A549].
作者: Jian Shen.;Jingkang He.;Xing Tang.;Rong Han.;Rui Li.;Chengcheng Xu.;Yajuan Wu.
来源: Zhongguo Fei Ai Za Zhi. 2013年16卷7期339-44页
It has been proven that cobrotoxin has anti-tumor effect while its role in lung cancer is rarely studied. The aim of this study is to assay the anti-tumor effect of cobrotoxin in cell line A549, and also to explore its possible mechanism related to autophagy and P38-MARK pathway.
325. [Impact of quercetin on the expression of heparanase in cervical cancer cells].
作者: Wen-ting Zhang.;Wei Zhang.;Ya-juan Zhong.;Qiong-ying Lü.;Jing Cheng.
来源: Zhonghua Fu Chan Ke Za Zhi. 2013年48卷3期198-203页
To detect the expression of heparanase (HPA) in cervical cancer cells and investigate the impact of quercetin on the expression of HPA, and the molecular mechanism that quercetin inhibits the growth of cervical cancer cells.
326. [The methylation of ZHX2 gene promoter enhances AFP gene expression in hepatocellular carcinoma].
To investigate the relationship between Zinc-fingers and homeoboxes 2 (ZHX2) promoter methylation and alpha-fetoprotein (AFP) gene expression, and analyze the mechanism of AFP gene expression.
327. [Coenzyme Q10 enhances the expression of Bcl-2 and inhibits the expressions of Bax and GSK-3β in the hippocampus of rats exposed to ischemia/reperfusion injury].
作者: Shuang Tian.;Di Wang.;Xiaodong Li.;Jianjie Tang.;Guang Han.;Yongyi Dai.
来源: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013年29卷7期698-701页
To investigate the effects of coenzyme Q10 pretreatment on the expressions of Bcl-2, Bax and glycogen synthase kinase-3β (GSK-3β) in rats suffering from ischemia/reperfusion injury.
328. [Effects of dexamethasone on expressions of IL-21 and its receptor in lungs of experimental asthma mice].
作者: Jing Gong.;Dunqiang Ren.;Yaling Luo.;Wenyan Lai.;Junhong Li.;Weiying Wang.
来源: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013年29卷6期561-4页
To observe the expressions of IL-21 and its receptor (IL-21R) in the lungs of chronic asthmatic mice, and investigate the effects of dexamethasone (Dex) on their expressions.
330. [Protective effect and mechanism of astragaloside IV on oxidative stress injury of mesangial cells].
作者: Ling-Ling Cao.;Wei-Zu Li.;Xiu-Lian Si.;Li Sun.;Wei-Ping Li.
来源: Zhongguo Zhong Yao Za Zhi. 2013年38卷5期725-30页
To study the protective effect of astragaloside IV (AS IV) on H2O2 induced human mesangial cells (HMC), and further explore its molecular mechanism.
331. [Regulative mechanisms of tubular epithelial to mesenchymal transition and interventional effects of Chinese herbal medicine].
作者: Xue-Jiao Yin.;Wei Sun.;Yi-Gang Wan.;Yue Tu.;Hong Liu.;Bing-Yin Yu.
来源: Zhongguo Zhong Yao Za Zhi. 2013年38卷5期648-52页
Epithelial to mesenchymal transition (EMT) has been proposed as a key role leading to the progressive tubulo-interstitial fibrosis (TIF). The tubular EMT is an highly regulated process involving four key steps including: loss of epithelial cell adhesion, de novo smooth muscle actin expression and actin reorganization, disruption of tubular basement membrane,and enhanced cell migration and invasion. These crucial processes are closely connected to the relative actions on many signaling pathways in EMT. Additionally, increasing evidences suggest that some Chinese herbal medicines and their extracts, such as Astragali Radix, Cordyceps, Salvia miltiorrhiza, as well as Chinese. herbal prescriptions including Astragalus Angelica mixture and Supplementing Qi and activating blood circulation decoction, could intervene the related events controlling EMT both in vitro and in vivo. Chinese herbal medicines could ameliorate TIF by intervening the course of EMT.
332. [Study on inhibitory effect of triterpenoid saponin from Ardisia japonica TSP02 on proliferation and metastasis of human hepatocellular carcinoma cells and its mechanism].
To study the effect of TSP02, a triterpenoid saponin compound from Ardisia japonica, on proliferation and metastasis of in vitro induced human hepatoma HepG2 cells and its molecular mechanism.
333. [Effect and mechanism of huatuo zaizao extractum on focal cerebral ischemia/reperfusion-induced blood-brain barrier injury in rats].
作者: Yong-Qiu Zheng.;Ming-Jiang Yao.;Jian-Xun Liu.;Wen-Ting Song.;Lei Li.;Sheng-Bo Liu.;Yan Hu.;Jing-Xi Si.
来源: Zhongguo Zhong Yao Za Zhi. 2013年38卷4期585-90页
To observe the effect and mechanism of Huatuo Zaizao extractum (HTZZ) on focal ischemia/reperfusion (I/R) blood-brain barrier injury induced by middle cerebral artery occlusion.
334. [Protective effects of polysaccharides from Dendrobium huoshanense on CCl4-induced acute liver injury in mice].
作者: Jing Huang.;Sheng-Li Li.;Hong-Wei Zhao.;Li-Hua Pan.;Hao-Qiao Sun.;Jian-Ping Luo.
来源: Zhongguo Zhong Yao Za Zhi. 2013年38卷4期528-32页
To study the protective effects of polysaccharides from Dendrobium huoshanense (DHP) against CCl4-induced liver injury in mice.
335. [Effect of autoinducer 2 on Riemerell antatipestifer adherence and invasion to Vero cells].
作者: Lei Liu.;Xiangan Han.;Rui Liu.;Hao Bai.;Hongliang Dong.;Chan Ding.;Haiwen Liu.;Shengqing Yu.
来源: Wei Sheng Wu Xue Bao. 2013年53卷3期313-9页
Autoinducer 2 (AI-2), used to communicate among bacterial species, regulates numerous physiological functions of bacteria. In this study, we studied the effect of AI-2 on adherence and invasion of Riemerella antatipestifer (RA) strain CH3 to Vero cells and transcriptional levels of virulence-related and metabolism-related genes were investigated.
336. [Effects of four kinds of Chinese medicine monomer on growth of PANC-1 xenograft tumor and studying of molecular mechanism].
The antitumor effects of icarisid II, timosaponin A-III, neferine and salidroside were studied in PANC-1 xenograft tumor.
337. [Effect of berberine, liensinine and neferine on HERG channel expression].
Immunofluorescence and Western blot methods were adopted for qualitative and quantitative detections of the effect of different concentrations of berberine, liensinine and neferine on the expression of stable transfection in HERG potassium channel in HEK-293 cells, as well as the effect of different concentrations of berberine on protein expression of Ikr channel in cardiac muscular tissues, in order to investigate the anti-arrhythmic mechanism of berberine, liensinine and neferine.
338. [Effect of hesperidin on behavior and HPA axis of rat model of chronic stress-induced depression].
To observe the effect of hesperidin on behavior and hypothalamic-pituitary-adrenal (HPA) axis of ratmodel of chronic stress-induced depression.
339. [Down-regulation of expression of α- smooth muscle actin in airway smooth muscle cells by allicin and its mechanisms].
To investigate the effect of allicin on the expression of α-smooth muscle actin (α-SMA) in airway smooth muscle cells (ASMC), and to evaluate the mechanism of allicin on inhibition of airway remodeling.
340. [Effects of oleic acid on expression of adiponectin and its PPARgamma mechanism in 3T3-L1 adipocytes].
To explore the effects of oleic acid on the gene and protein expression of adiponectin and its PPARgamma mechanism in 3T3-l1 adipocytes.
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