1. New-Onset Seizure in Adults and Adolescents: A Review.
Approximately 8% to 10% of the population will experience a seizure during their lifetime. Only about 2% to 3% of patients go on to develop epilepsy. Understanding the underlying etiology leading to an accurate diagnosis is necessary to ensure appropriate treatment and that patients with low risk for recurrence are not treated unnecessarily.
2. Effect of a Primary Care-Based Psychological Intervention on Symptoms of Common Mental Disorders in Zimbabwe: A Randomized Clinical Trial.
作者: Dixon Chibanda.;Helen A Weiss.;Ruth Verhey.;Victoria Simms.;Ronald Munjoma.;Simbarashe Rusakaniko.;Alfred Chingono.;Epiphania Munetsi.;Tarisai Bere.;Ethel Manda.;Melanie Abas.;Ricardo Araya.
来源: JAMA. 2016年316卷24期2618-2626页
Depression and anxiety are common mental disorders globally but are rarely recognized or treated in low-income settings. Task-shifting of mental health care to lay health workers (LHWs) might decrease the treatment gap.
3. Association Between Hospital Penalty Status Under the Hospital Readmission Reduction Program and Readmission Rates for Target and Nontarget Conditions.
作者: Nihar R Desai.;Joseph S Ross.;Ji Young Kwon.;Jeph Herrin.;Kumar Dharmarajan.;Susannah M Bernheim.;Harlan M Krumholz.;Leora I Horwitz.
来源: JAMA. 2016年316卷24期2647-2656页
Readmission rates declined after announcement of the Hospital Readmission Reduction Program (HRRP), which penalizes hospitals for excess readmissions for acute myocardial infarction (AMI), heart failure (HF), and pneumonia.
4. US Spending on Personal Health Care and Public Health, 1996-2013.
作者: Joseph L Dieleman.;Ranju Baral.;Maxwell Birger.;Anthony L Bui.;Anne Bulchis.;Abigail Chapin.;Hannah Hamavid.;Cody Horst.;Elizabeth K Johnson.;Jonathan Joseph.;Rouselle Lavado.;Liya Lomsadze.;Alex Reynolds.;Ellen Squires.;Madeline Campbell.;Brendan DeCenso.;Daniel Dicker.;Abraham D Flaxman.;Rose Gabert.;Tina Highfill.;Mohsen Naghavi.;Noelle Nightingale.;Tara Templin.;Martin I Tobias.;Theo Vos.;Christopher J L Murray.
来源: JAMA. 2016年316卷24期2627-2646页
US health care spending has continued to increase, and now accounts for more than 17% of the US economy. Despite the size and growth of this spending, little is known about how spending on each condition varies by age and across time.
5. Intra-articular Corticosteroids for Osteoarthritis of the Knee.
Are intra-articular corticosteroids associated with improvement in pain and physical function compared with sham injection or no intervention in patients with knee osteoarthritis?
6. Serologic Screening for Genital Herpes: An Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
作者: Cynthia Feltner.;Catherine Grodensky.;Charles Ebel.;Jennifer C Middleton.;Russell P Harris.;Mahima Ashok.;Daniel E Jonas.
来源: JAMA. 2016年316卷23期2531-2543页
Genital herpes simplex virus (HSV) infection is a prevalent sexually transmitted infection. Vertical transmission of HSV can lead to fetal morbidity and mortality.
7. Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Recommendation Statement.
作者: .;Kirsten Bibbins-Domingo.;David C Grossman.;Susan J Curry.;Karina W Davidson.;John W Epling.;Francisco A R García.;Alex R Kemper.;Alex H Krist.;Ann E Kurth.;C Seth Landefeld.;Carol M Mangione.;William R Phillips.;Maureen G Phipps.;Michael P Pignone.;Michael Silverstein.;Chien-Wen Tseng.
来源: JAMA. 2016年316卷23期2525-2530页
Genital herpes is a prevalent sexually transmitted infection in the United States, occurring in almost 1 in 6 persons aged 14 to 49 years. Infection is caused by 2 subtypes of the herpes simplex virus (HSV), HSV-1 and HSV-2. Antiviral medications may provide symptomatic relief from outbreaks but do not cure HSV infection. Neonatal herpes infection, while uncommon, can result in substantial morbidity and mortality.
8. Association Between the Birth of an Infant With Major Congenital Anomalies and Subsequent Risk of Mortality in Their Mothers.
作者: Eyal Cohen.;Erzsébet Horváth-Puhó.;Joel G Ray.;Lars Pedersen.;Nancy Adler.;Anne Gulbech Ording.;Paul H Wise.;Arnold Milstein.;Henrik Toft Sørensen.
来源: JAMA. 2016年316卷23期2515-2524页
Giving birth to a child with a major birth defect is a serious life event for a woman, yet little is known about the long-term health consequences for the mother.
9. Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial.
作者: Anna Wald.;Burkhard Timmler.;Amalia Magaret.;Terri Warren.;Stephen Tyring.;Christine Johnston.;Kenneth Fife.;Stacy Selke.;Meei-Li Huang.;Hans-Peter Stobernack.;Holger Zimmermann.;Lawrence Corey.;Alexander Birkmann.;Helga Ruebsamen-Schaeff.
来源: JAMA. 2016年316卷23期2495-2503页
Current therapy of herpes infections relies on nucleoside analogues. Pritelivir is a well-tolerated novel herpes simplex virus (HSV) helicase-primase inhibitor that reduced genital shedding and lesions.
10. Association Between Early Participation in Physical Activity Following Acute Concussion and Persistent Postconcussive Symptoms in Children and Adolescents.
作者: Anne M Grool.;Mary Aglipay.;Franco Momoli.;William P Meehan.;Stephen B Freedman.;Keith Owen Yeates.;Jocelyn Gravel.;Isabelle Gagnon.;Kathy Boutis.;Willem Meeuwisse.;Nick Barrowman.;Andrée-Anne Ledoux.;Martin H Osmond.;Roger Zemek.; .
来源: JAMA. 2016年316卷23期2504-2514页
Although concussion treatment guidelines advocate rest in the immediate postinjury period until symptoms resolve, no clear evidence has determined that avoiding physical activity expedites recovery.
11. US County-Level Trends in Mortality Rates for Major Causes of Death, 1980-2014.
作者: Laura Dwyer-Lindgren.;Amelia Bertozzi-Villa.;Rebecca W Stubbs.;Chloe Morozoff.;Michael J Kutz.;Chantal Huynh.;Ryan M Barber.;Katya A Shackelford.;Johan P Mackenbach.;Frank J van Lenthe.;Abraham D Flaxman.;Mohsen Naghavi.;Ali H Mokdad.;Christopher J L Murray.
来源: JAMA. 2016年316卷22期2385-2401页
County-level patterns in mortality rates by cause have not been systematically described but are potentially useful for public health officials, clinicians, and researchers seeking to improve health and reduce geographic disparities.
12. Association Between Learning Environment Interventions and Medical Student Well-being: A Systematic Review.
作者: Lauren T Wasson.;Amberle Cusmano.;Laura Meli.;Irene Louh.;Louise Falzon.;Meghan Hampsey.;Geoffrey Young.;Jonathan Shaffer.;Karina W Davidson.
来源: JAMA. 2016年316卷21期2237-2252页
Concerns exist about the current quality of undergraduate medical education and its effect on students' well-being.
13. Association Between End-of-Rotation Resident Transition in Care and Mortality Among Hospitalized Patients.
作者: Joshua L Denson.;Ashley Jensen.;Harry S Saag.;Binhuan Wang.;Yixin Fang.;Leora I Horwitz.;Laura Evans.;Scott E Sherman.
来源: JAMA. 2016年316卷21期2204-2213页
Shift-to-shift transitions in care among house staff are associated with adverse events. However, the association between end-of-rotation transition (in which care of the patient is transferred) and adverse events is uncertain.
14. Correlations Between Ratings on the Resident Annual Evaluation Summary and the Internal Medicine Milestones and Association With ABIM Certification Examination Scores Among US Internal Medicine Residents, 2013-2014.
作者: Karen E Hauer.;Jonathan Vandergrift.;Brian Hess.;Rebecca S Lipner.;Eric S Holmboe.;Sarah Hood.;William Iobst.;Stanley J Hamstra.;Furman S McDonald.
来源: JAMA. 2016年316卷21期2253-2262页
US internal medicine residency programs are now required to rate residents using milestones. Evidence of validity of milestone ratings is needed.
15. Prevalence of Depression, Depressive Symptoms, and Suicidal Ideation Among Medical Students: A Systematic Review and Meta-Analysis.
作者: Lisa S Rotenstein.;Marco A Ramos.;Matthew Torre.;J Bradley Segal.;Michael J Peluso.;Constance Guille.;Srijan Sen.;Douglas A Mata.
来源: JAMA. 2016年316卷21期2214-2236页
Medical students are at high risk for depression and suicidal ideation. However, the prevalence estimates of these disorders vary between studies.
16. Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs.
作者: Varun Gulshan.;Lily Peng.;Marc Coram.;Martin C Stumpe.;Derek Wu.;Arunachalam Narayanaswamy.;Subhashini Venugopalan.;Kasumi Widner.;Tom Madams.;Jorge Cuadros.;Ramasamy Kim.;Rajiv Raman.;Philip C Nelson.;Jessica L Mega.;Dale R Webster.
来源: JAMA. 2016年316卷22期2402-2410页
Deep learning is a family of computational methods that allow an algorithm to program itself by learning from a large set of examples that demonstrate the desired behavior, removing the need to specify rules explicitly. Application of these methods to medical imaging requires further assessment and validation.
17. Screening for Colorectal Cancer and Evolving Issues for Physicians and Patients: A Review.
作者: David Lieberman.;Uri Ladabaum.;Marcia Cruz-Correa.;Carla Ginsburg.;John M Inadomi.;Lawrence S Kim.;Francis M Giardiello.;Richard C Wender.
来源: JAMA. 2016年316卷20期2135-2145页
Colorectal cancer (CRC) is the second-leading cause of cancer death in the United States. Screening can reduce CRC mortality and incidence, and numerous screening options, although available, complicate informed decision making. This review provides evidence-based tools for primary care physicians to identify patients with higher-than-average-risk and engage patients in informed decision making about CRC screening options.
18. Association Between Palliative Care and Patient and Caregiver Outcomes: A Systematic Review and Meta-analysis.
作者: Dio Kavalieratos.;Jennifer Corbelli.;Di Zhang.;J Nicholas Dionne-Odom.;Natalie C Ernecoff.;Janel Hanmer.;Zachariah P Hoydich.;Dara Z Ikejiani.;Michele Klein-Fedyshin.;Camilla Zimmermann.;Sally C Morton.;Robert M Arnold.;Lucas Heller.;Yael Schenker.
来源: JAMA. 2016年316卷20期2104-2114页
The use of palliative care programs and the number of trials assessing their effectiveness have increased.
19. Effect of Inpatient Palliative Care on Quality of Life 2 Weeks After Hematopoietic Stem Cell Transplantation: A Randomized Clinical Trial.
作者: Areej El-Jawahri.;Thomas LeBlanc.;Harry VanDusen.;Lara Traeger.;Joseph A Greer.;William F Pirl.;Vicki A Jackson.;Jason Telles.;Alison Rhodes.;Thomas R Spitzer.;Steven McAfee.;Yi-Bin A Chen.;Stephanie S Lee.;Jennifer S Temel.
来源: JAMA. 2016年316卷20期2094-2103页
During hospitalization for hematopoietic stem cell transplantation (HCT), patients receive high-dose chemotherapy before transplantation and experience significant physical and psychological symptoms and poor quality of life (QOL).
20. US Emergency Department Visits for Outpatient Adverse Drug Events, 2013-2014.
作者: Nadine Shehab.;Maribeth C Lovegrove.;Andrew I Geller.;Kathleen O Rose.;Nina J Weidle.;Daniel S Budnitz.
来源: JAMA. 2016年316卷20期2115-2125页
The Patient Protection and Affordable Care Act of 2010 brought attention to adverse drug events in national patient safety efforts. Updated, detailed, nationally representative data describing adverse drug events can help focus these efforts.
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