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2. Assessing Hospital Performance After Percutaneous Coronary Intervention Using Big Data.
作者: Jacob V Spertus.;Sharon-Lise T Normand.;Robert Wolf.;Matt Cioffi.;Ann Lovett.;Sherri Rose.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期659-669页
Although risk adjustment remains a cornerstone for comparing outcomes across hospitals, optimal strategies continue to evolve in the presence of many confounders. We compared conventional regression-based model to approaches particularly suited to leveraging big data.
3. Early Detection of Heart Failure Using Electronic Health Records: Practical Implications for Time Before Diagnosis, Data Diversity, Data Quantity, and Data Density.
作者: Kenney Ng.;Steven R Steinhubl.;Christopher deFilippi.;Sanjoy Dey.;Walter F Stewart.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期649-658页
Using electronic health records data to predict events and onset of diseases is increasingly common. Relatively little is known, although, about the tradeoffs between data requirements and model utility.
4. Association Between Physician Teamwork and Health System Outcomes After Coronary Artery Bypass Grafting.
作者: John M Hollingsworth.;Russell J Funk.;Spencer A Garrison.;Jason Owen-Smith.;Samuel A Kaufman.;Francis D Pagani.;Brahmajee K Nallamothu.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期641-648页
Patients undergoing coronary artery bypass grafting (CABG) must often see multiple providers dispersed across many care locations. To test whether teamwork (assessed with the bipartite clustering coefficient) among these physicians is a determinant of surgical outcomes, we examined national Medicare data from patients undergoing CABG.
5. Analysis of Machine Learning Techniques for Heart Failure Readmissions.
作者: Bobak J Mortazavi.;Nicholas S Downing.;Emily M Bucholz.;Kumar Dharmarajan.;Ajay Manhapra.;Shu-Xia Li.;Sahand N Negahban.;Harlan M Krumholz.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期629-640页
The current ability to predict readmissions in patients with heart failure is modest at best. It is unclear whether machine learning techniques that address higher dimensional, nonlinear relationships among variables would enhance prediction. We sought to compare the effectiveness of several machine learning algorithms for predicting readmissions.
8. Characterizing Teamwork in Cardiovascular Care Outcomes: A Network Analytics Approach.
作者: Matthew B Carson.;Denise M Scholtens.;Conor N Frailey.;Stephanie J Gravenor.;Emilie S Powell.;Amy Y Wang.;Gayle Shier Kricke.;Faraz S Ahmad.;R Kannan Mutharasan.;Nicholas D Soulakis.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期670-678页
The nature of teamwork in healthcare is complex and interdisciplinary, and provider collaboration based on shared patient encounters is crucial to its success. Characterizing the intensity of working relationships with risk-adjusted patient outcomes supplies insight into provider interactions in a hospital environment.
9. Role of Diastolic Stress Testing in the Evaluation for Heart Failure With Preserved Ejection Fraction: A Simultaneous Invasive-Echocardiographic Study.
作者: Masaru Obokata.;Garvan C Kane.;Yogesh N V Reddy.;Thomas P Olson.;Vojtech Melenovsky.;Barry A Borlaug.
来源: Circulation. 2017年135卷9期825-838页
Diagnosis of heart failure with preserved ejection fraction (HFpEF) is challenging and relies largely on demonstration of elevated cardiac filling pressures (pulmonary capillary wedge pressure). Current guidelines recommend use of natriuretic peptides (N-terminal pro-B type natriuretic peptide) and rest/exercise echocardiography (E/e' ratio) to make this determination. Data to support this practice are conflicting.
10. Comparison of the Efficacy and Safety of Early Rule-Out Pathways for Acute Myocardial Infarction.
作者: Andrew R Chapman.;Atul Anand.;Jasper Boeddinghaus.;Amy V Ferry.;Dennis Sandeman.;Philip D Adamson.;Jack Andrews.;Stephanie Tan.;Sheun F Cheng.;Michelle D'Souza.;Kate Orme.;Fiona E Strachan.;Thomas Nestelberger.;Raphael Twerenbold.;Patrick Badertscher.;Tobias Reichlin.;Alasdair Gray.;Anoop S V Shah.;Christian Mueller.;David E Newby.;Nicholas L Mills.
来源: Circulation. 2017年135卷17期1586-1596页
High-sensitivity cardiac troponin assays enable myocardial infarction to be ruled out earlier, but the optimal approach is uncertain. We compared the European Society of Cardiology rule-out pathway with a pathway that incorporates lower cardiac troponin concentrations to risk stratify patients.
11. Neurological Injury and Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction.
作者: Mark A Fogel.;Christine Li.;Okan U Elci.;Tom Pawlowski.;Peter J Schwab.;Felice Wilson.;Susan C Nicolson.;Lisa M Montenegro.;Laura Diaz.;Thomas L Spray.;J William Gaynor.;Stephanie Fuller.;Christopher Mascio.;Marc S Keller.;Matthew A Harris.;Kevin K Whitehead.;Jim Bethel.;Arastoo Vossough.;Daniel J Licht.
来源: Circulation. 2017年135卷7期671-682页
Patients with a single ventricle experience a high rate of brain injury and adverse neurodevelopmental outcome; however, the incidence of brain abnormalities throughout surgical reconstruction and their relationship with cerebral blood flow, oxygen delivery, and carbon dioxide reactivity remain unknown.
12. Releasing the Brakes on the Fibrinolytic System in Pulmonary Emboli: Unique Effects of Plasminogen Activation and α2-Antiplasmin Inactivation.
In patients with hemodynamically significant pulmonary embolism, physiological fibrinolysis fails to dissolve thrombi acutely and r-tPA (recombinant tissue-type plasminogen activator) therapy may be required, despite its bleeding risk. To examine potential mechanisms, we analyzed the expression of key fibrinolytic molecules in experimental pulmonary emboli, assessed the contribution of α2-antiplasmin to fibrinolytic failure, and compared the effects of plasminogen activation and α2-antiplasmin inactivation on experimental thrombus dissolution and bleeding.
15. Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans.
作者: Gissette Reyes-Soffer.;Marianna Pavlyha.;Colleen Ngai.;Tiffany Thomas.;Stephen Holleran.;Rajasekhar Ramakrishnan.;Wahida Karmally.;Renu Nandakumar.;Nelson Fontanez.;Joseph Obunike.;Santica M Marcovina.;Alice H Lichtenstein.;Nirupa R Matthan.;James Matta.;Magali Maroccia.;Frederic Becue.;Franck Poitiers.;Brian Swanson.;Lisa Cowan.;William J Sasiela.;Howard K Surks.;Henry N Ginsberg.
来源: Circulation. 2017年135卷4期352-362页
Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified increased hepatic LDL receptors as the basis for LDL lowering by PCSK9 inhibitors, there have been no human studies characterizing the effects of PCSK9 inhibitors on lipoprotein metabolism. In particular, it is not known whether inhibition of PCSK9 has any effects on very low-density lipoprotein or intermediate-density lipoprotein (IDL) metabolism. Inhibition of PCSK9 also results in reductions of plasma lipoprotein (a) levels. The regulation of plasma Lp(a) levels, including the role of LDL receptors in the clearance of Lp(a), is poorly defined, and no mechanistic studies of the Lp(a) lowering by alirocumab in humans have been published to date.
16. Follow-Up of a Prospective Surgical Strategy to Prevent Intra-Atrial Reentrant Tachycardia After the Fontan Operation.
作者: Ian H Law.;Osman Alam.;Edward L Bove.;Richard G Ohye.;David J Bradley.;Sunkyung Yu.;Macdonald Dick.
来源: Circ Arrhythm Electrophysiol. 2016年9卷12期
Intra-atrial reentrant tachycardia (IART) after the Fontan operation had an early reported incidence of 10% to 35% during early and intermediate follow-up and posed substantial management challenges.
17. Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension.
作者: Ian P Temple.;Sunil Jit R J Logantha.;Mais Absi.;Yu Zhang.;Eleftheria Pervolaraki.;Joseph Yanni.;Andrew Atkinson.;Maria Petkova.;Gillian M Quigley.;Simon Castro.;Mark Drinkhill.;Heiko Schneider.;Oliver Monfredi.;Elizabeth Cartwright.;Min Zi.;Tomoko T Yamanushi.;Vaikom S Mahadevan.;Alison M Gurney.;Ed White.;Henggui Zhang.;George Hart.;Mark R Boyett.;Halina Dobrzynski.
来源: Circ Arrhythm Electrophysiol. 2016年9卷12期
Heart block is associated with pulmonary hypertension, and the aim of the study was to test the hypothesis that the heart block is the result of a change in the ion channel transcriptome of the atrioventricular (AV) node.
18. Predictors of Death in Contemporary Adult Patients With Eisenmenger Syndrome: A Multicenter Study.
作者: Aleksander Kempny.;Cristel Sørensen Hjortshøj.;Hong Gu.;Wei Li.;Alexander R Opotowsky.;Michael J Landzberg.;Annette Schophuus Jensen.;Lars Søndergaard.;Mette-Elise Estensen.;Ulf Thilén.;Werner Budts.;Barbara J Mulder.;Ilja Blok.;Lidia Tomkiewicz-Pająk.;Kamil Szostek.;Michele D'Alto.;Giancarlo Scognamiglio.;Katja Prokšelj.;Gerhard-Paul Diller.;Konstantinos Dimopoulos.;Stephen J Wort.;Michael A Gatzoulis.
来源: Circulation. 2017年135卷15期1432-1440页
Eisenmenger syndrome is associated with substantial morbidity and mortality. There is no consensus, however, on mortality risk stratification. We aimed to investigate survival and predictors of death in a large, contemporary cohort of Eisenmenger syndrome patients.
19. Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization.
作者: Neal A Chatterjee.;Franco Giulianini.;Bastiaan Geelhoed.;Kathryn L Lunetta.;Jeffrey R Misialek.;Maartje N Niemeijer.;Michiel Rienstra.;Lynda M Rose.;Albert V Smith.;Dan E Arking.;Patrick T Ellinor.;Jan Heeringa.;Honghuang Lin.;Steven A Lubitz.;Elsayed Z Soliman.;Niek Verweij.;Alvaro Alonso.;Emelia J Benjamin.;Vilmundur Gudnason.;Bruno H C Stricker.;Pim Van Der Harst.;Daniel I Chasman.;Christine M Albert.
来源: Circulation. 2017年135卷8期741-754页
Observational studies have identified an association between body mass index (BMI) and incident atrial fibrillation (AF). Inferring causality from observational studies, however, is subject to residual confounding, reverse causation, and bias. The primary objective of this study was to evaluate the causal association between BMI and AF by using genetic predictors of BMI.
20. Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials.
作者: Andrew Bivard.;Xuya Huang.;Patrick McElduff.;Christopher R Levi.;Bruce C V Campbell.;Bharath Kumar Cheripelli.;Dheeraj Kalladka.;Fiona Catherine Moreton.;Ian Ford.;Christopher F Bladin.;Stephen M Davis.;Geoffrey A Donnan.;Keith W Muir.;Mark W Parsons.
来源: Circulation. 2017年135卷5期440-448页
We pooled 2 clinical trials of tenecteplase compared with alteplase for the treatment of acute ischemic stroke, 1 that demonstrated superiority of tenecteplase and the other that showed no difference between the treatments in patient clinical outcomes. We tested the hypotheses that reperfusion therapy with tenecteplase would be superior to alteplase in improving functional outcomes in the group of patients with target mismatch as identified with advanced imaging.
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