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4. Assessing Hospital Performance After Percutaneous Coronary Intervention Using Big Data.
作者: Jacob V Spertus.;Sharon-Lise T Normand.;Robert Wolf.;Matt Cioffi.;Ann Lovett.;Sherri Rose.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期659-669页
Although risk adjustment remains a cornerstone for comparing outcomes across hospitals, optimal strategies continue to evolve in the presence of many confounders. We compared conventional regression-based model to approaches particularly suited to leveraging big data.
5. Early Detection of Heart Failure Using Electronic Health Records: Practical Implications for Time Before Diagnosis, Data Diversity, Data Quantity, and Data Density.
作者: Kenney Ng.;Steven R Steinhubl.;Christopher deFilippi.;Sanjoy Dey.;Walter F Stewart.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期649-658页
Using electronic health records data to predict events and onset of diseases is increasingly common. Relatively little is known, although, about the tradeoffs between data requirements and model utility.
6. Association Between Physician Teamwork and Health System Outcomes After Coronary Artery Bypass Grafting.
作者: John M Hollingsworth.;Russell J Funk.;Spencer A Garrison.;Jason Owen-Smith.;Samuel A Kaufman.;Francis D Pagani.;Brahmajee K Nallamothu.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期641-648页
Patients undergoing coronary artery bypass grafting (CABG) must often see multiple providers dispersed across many care locations. To test whether teamwork (assessed with the bipartite clustering coefficient) among these physicians is a determinant of surgical outcomes, we examined national Medicare data from patients undergoing CABG.
7. Analysis of Machine Learning Techniques for Heart Failure Readmissions.
作者: Bobak J Mortazavi.;Nicholas S Downing.;Emily M Bucholz.;Kumar Dharmarajan.;Ajay Manhapra.;Shu-Xia Li.;Sahand N Negahban.;Harlan M Krumholz.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期629-640页
The current ability to predict readmissions in patients with heart failure is modest at best. It is unclear whether machine learning techniques that address higher dimensional, nonlinear relationships among variables would enhance prediction. We sought to compare the effectiveness of several machine learning algorithms for predicting readmissions.
8. Identifying Drug-Drug Interactions by Data Mining: A Pilot Study of Warfarin-Associated Drug Interactions.
作者: Peter Wæde Hansen.;Line Clemmensen.;Thomas S G Sehested.;Emil Loldrup Fosbøl.;Christian Torp-Pedersen.;Lars Køber.;Gunnar H Gislason.;Charlotte Andersson.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期621-628页
Knowledge about drug-drug interactions commonly arises from preclinical trials, from adverse drug reports, or based on knowledge of mechanisms of action. Our aim was to investigate whether drug-drug interactions were discoverable without prior hypotheses using data mining. We focused on warfarin-drug interactions as the prototype.
12. Characterizing Teamwork in Cardiovascular Care Outcomes: A Network Analytics Approach.
作者: Matthew B Carson.;Denise M Scholtens.;Conor N Frailey.;Stephanie J Gravenor.;Emilie S Powell.;Amy Y Wang.;Gayle Shier Kricke.;Faraz S Ahmad.;R Kannan Mutharasan.;Nicholas D Soulakis.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期670-678页
The nature of teamwork in healthcare is complex and interdisciplinary, and provider collaboration based on shared patient encounters is crucial to its success. Characterizing the intensity of working relationships with risk-adjusted patient outcomes supplies insight into provider interactions in a hospital environment.
13. Role of Diastolic Stress Testing in the Evaluation for Heart Failure With Preserved Ejection Fraction: A Simultaneous Invasive-Echocardiographic Study.
作者: Masaru Obokata.;Garvan C Kane.;Yogesh N V Reddy.;Thomas P Olson.;Vojtech Melenovsky.;Barry A Borlaug.
来源: Circulation. 2017年135卷9期825-838页
Diagnosis of heart failure with preserved ejection fraction (HFpEF) is challenging and relies largely on demonstration of elevated cardiac filling pressures (pulmonary capillary wedge pressure). Current guidelines recommend use of natriuretic peptides (N-terminal pro-B type natriuretic peptide) and rest/exercise echocardiography (E/e' ratio) to make this determination. Data to support this practice are conflicting.
14. Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis.
作者: Alessandra Familiari.;Maddalena Morlando.;Asma Khalil.;Sven-Erik Sonesson.;Carolina Scala.;Giuseppe Rizzo.;Gelsomina Del Sordo.;Chiara Vassallo.;Maria Elena Flacco.;Lamberto Manzoli.;Antonio Lanzone.;Giovanni Scambia.;Ganesh Acharya.;Francesco D'Antonio.
来源: Circulation. 2017年135卷8期772-785页
Prenatal diagnosis of coarctation of the aorta (CoA) is still challenging and affected by high rates of false-positive diagnoses. The aim of this study was to ascertain the strength of association and to quantify the diagnostic accuracy of different ultrasound signs in predicting CoA prenatally.
15. Body Mass Index and Mortality Among Adults Undergoing Cardiac Surgery: A Nationwide Study With a Systematic Review and Meta-Analysis.
作者: Giovanni Mariscalco.;Marcin J Wozniak.;Alan G Dawson.;Giuseppe F Serraino.;Richard Porter.;Mintu Nath.;Catherine Klersy.;Tracy Kumar.;Gavin J Murphy.
来源: Circulation. 2017年135卷9期850-863页
In an apparent paradox, morbidity and mortality are lower in obese patients undergoing cardiac surgery, although the nature of this association is unclear. We sought to determine whether the obesity paradox observed in cardiac surgery is attributable to reverse epidemiology, bias, or confounding.
16. Comparison of the Efficacy and Safety of Early Rule-Out Pathways for Acute Myocardial Infarction.
作者: Andrew R Chapman.;Atul Anand.;Jasper Boeddinghaus.;Amy V Ferry.;Dennis Sandeman.;Philip D Adamson.;Jack Andrews.;Stephanie Tan.;Sheun F Cheng.;Michelle D'Souza.;Kate Orme.;Fiona E Strachan.;Thomas Nestelberger.;Raphael Twerenbold.;Patrick Badertscher.;Tobias Reichlin.;Alasdair Gray.;Anoop S V Shah.;Christian Mueller.;David E Newby.;Nicholas L Mills.
来源: Circulation. 2017年135卷17期1586-1596页
High-sensitivity cardiac troponin assays enable myocardial infarction to be ruled out earlier, but the optimal approach is uncertain. We compared the European Society of Cardiology rule-out pathway with a pathway that incorporates lower cardiac troponin concentrations to risk stratify patients.
17. Neurological Injury and Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction.
作者: Mark A Fogel.;Christine Li.;Okan U Elci.;Tom Pawlowski.;Peter J Schwab.;Felice Wilson.;Susan C Nicolson.;Lisa M Montenegro.;Laura Diaz.;Thomas L Spray.;J William Gaynor.;Stephanie Fuller.;Christopher Mascio.;Marc S Keller.;Matthew A Harris.;Kevin K Whitehead.;Jim Bethel.;Arastoo Vossough.;Daniel J Licht.
来源: Circulation. 2017年135卷7期671-682页
Patients with a single ventricle experience a high rate of brain injury and adverse neurodevelopmental outcome; however, the incidence of brain abnormalities throughout surgical reconstruction and their relationship with cerebral blood flow, oxygen delivery, and carbon dioxide reactivity remain unknown.
18. Angiogenic Imbalance and Residual Myocardial Injury in Recovered Peripartum Cardiomyopathy Patients.
作者: Sorel Goland.;Jean Marc Weinstein.;Adi Zalik.;Rafael Kuperstein.;Liaz Zilberman.;Sara Shimoni.;Michael Arad.;Tuvia Ben Gal.;Jacob George.
来源: Circ Heart Fail. 2016年9卷11期
Recent studies suggest that angiogenic imbalance during pregnancy may lead to acute peripartum cardiomyopathy (PPCM). We propose that angiogenic imbalance and residual cardiac dysfunction may exist even after recovery from PPCM.
19. Reductions in N-Terminal Pro-Brain Natriuretic Peptide Levels Are Associated With Lower Mortality and Heart Failure Hospitalization Rates in Patients With Heart Failure With Mid-Range and Preserved Ejection Fraction.
作者: Gianluigi Savarese.;Camilla Hage.;Nicola Orsini.;Ulf Dahlström.;Pasquale Perrone-Filardi.;Giuseppe M C Rosano.;Lars H Lund.
来源: Circ Heart Fail. 2016年9卷11期
In heart failure with mid-range ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF), feasible surrogate end points are needed for phase II trials. The aim was to assess whether a reduction in N-terminal pro-B-type natriuretic peptide (NT-proBNP) is associated with improved mortality/morbidity in an unselected population of HFmrEF and HFpEF patients.
20. Sleep-Disordered Breathing Exacerbates Muscle Vasoconstriction and Sympathetic Neural Activation in Patients with Systolic Heart Failure.
作者: Denise M L Lobo.;Patricia F Trevizan.;Edgar Toschi-Dias.;Patricia A Oliveira.;Rafael B Piveta.;Dirceu R Almeida.;Charles Mady.;Edimar A Bocchi.;Geraldo Lorenzi-Filho.;Holly R Middlekauff.;Carlos E Negrão.
来源: Circ Heart Fail. 2016年9卷11期
Sleep-disordered breathing (SDB) is common in patients with heart failure (HF), and hypoxia and hypercapnia episodes activate chemoreceptors stimulating autonomic reflex responses. We tested the hypothesis that muscle vasoconstriction and muscle sympathetic nerve activity (MSNA) in response to hypoxia and hypercapnia would be more pronounced in patients with HF and SDB than in patients with HF without SDB (NoSBD).
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