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1. A comparative effectiveness trial of two faecal immunochemical tests for haemoglobin (FIT). Assessment of test performance and adherence in a single round of a population-based screening programme for colorectal cancer.
作者: Basilio Passamonti.;Morena Malaspina.;Callum G Fraser.;Beatrice Tintori.;Angela Carlani.;Valentina D'Angelo.;Paola Galeazzi.;Eugenio Di Dato.;Loretta Mariotti.;Simonetta Bulletti.;Maria Rosaria D'Amico.;Daniela Gustinucci.;Nadia Martinelli.;Nicoletta Spita.;Elena Cesarini.;Tiziana Rubeca.;Mariadonata Giaimo.;Nereo Segnan.;Carlo Senore.
来源: Gut. 2018年67卷3期485-496页
To compare acceptability and diagnostic accuracy of a recently available faecal immunochemical test (FIT) system (HM-JACKarc) with the FIT routinely used in an established screening programme (OC-Sensor).
2. Effect of vedolizumab (anti-α4β7-integrin) therapy on histological healing and mucosal gene expression in patients with UC.
作者: Ingrid Arijs.;Gert De Hertogh.;Bart Lemmens.;Leentje Van Lommel.;Magali de Bruyn.;Wiebe Vanhove.;Isabelle Cleynen.;Kathleen Machiels.;Marc Ferrante.;Frans Schuit.;Gert Van Assche.;Paul Rutgeerts.;Severine Vermeire.
来源: Gut. 2018年67卷1期43-52页
Lymphocyte recruitment to the inflamed gut is increased in UC. Inhibition of this cell trafficking by vedolizumab (VDZ) was successful in inducing and maintaining remission and in induction of endoscopic mucosal healing. There are no data on histological healing with VDZ. We studied histological changes following VDZ therapy and compared gene expression in patients with UC before and after therapy.
3. Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD.
作者: Xiaofang Huo.;Agoston T Agoston.;Kerry B Dunbar.;Daisha J Cipher.;Xi Zhang.;Chunhua Yu.;Edaire Cheng.;Qiuyang Zhang.;Thai H Pham.;Uttam K Tambar.;Richard K Bruick.;David H Wang.;Robert D Odze.;Stuart J Spechler.;Rhonda F Souza.
来源: Gut. 2017年66卷9期1542-1554页
In an earlier study wherein we induced acute reflux by interrupting proton pump inhibitor (PPI) therapy in patients with reflux oesophagitis (RO) healed by PPIs, we refuted the traditional concept that RO develops as an acid burn. The present study explored our alternative hypothesis that RO results from reflux-stimulated production of pro-inflammatory molecules mediated by hypoxia-inducible factors (HIFs).
4. Real-life chromoendoscopy for neoplasia detection and characterisation in long-standing IBD.
作者: Sabela Carballal.;Sandra Maisterra.;Antonio López-Serrano.;Antonio Z Gimeno-García.;María Isabel Vera.;José Carlos Marín-Garbriel.;José Díaz-Tasende.;Lucía Márquez.;Marco Antonio Álvarez.;Luis Hernández.;Luisa De Castro.;Jordi Gordillo.;Ignasi Puig.;Pablo Vega.;Marco Bustamante-Balén.;Juan Acevedo.;Beatriz Peñas.;María López-Cerón.;Elena Ricart.;Miriam Cuatrecasas.;Mireya Jimeno.;María Pellisé.; .
来源: Gut. 2018年67卷1期70-78页
Outside clinical trials, the effectiveness of chromoendoscopy (CE) for long-standing IBD surveillance is controversial. We aimed to assess the effectiveness of CE for neoplasia detection and characterisation, in real-life.
5. Randomised controlled trial of long-term maintenance corticosteroid therapy in patients with autoimmune pancreatitis.
作者: Atsushi Masamune.;Isao Nishimori.;Kazuhiro Kikuta.;Ichiro Tsuji.;Nobumasa Mizuno.;Tatsuo Iiyama.;Atsushi Kanno.;Yuichi Tachibana.;Tetsuhide Ito.;Terumi Kamisawa.;Kazushige Uchida.;Hideaki Hamano.;Hiroaki Yasuda.;Junichi Sakagami.;Akira Mitoro.;Masashi Taguchi.;Yasuyuki Kihara.;Hiroyuki Sugimoto.;Yoshiki Hirooka.;Satoshi Yamamoto.;Kazuo Inui.;Osamu Inatomi.;Akira Andoh.;Kazuyuki Nakahara.;Hiroyuki Miyakawa.;Shin Hamada.;Shigeyuki Kawa.;Kazuichi Okazaki.;Tooru Shimosegawa.; .
来源: Gut. 2017年66卷3期487-494页
Corticosteroid has been established as the standard therapy for autoimmune pancreatitis (AIP), but the requirement for maintenance corticosteroid therapy is controversial. We conducted a randomised controlled trial to clarify the efficacy of maintenance corticosteroid therapy in patients with AIP.
6. Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B.
作者: Julianne Bayliss.;Lilly Yuen.;Gillian Rosenberg.;Darren Wong.;Margaret Littlejohn.;Kathleen Jackson.;Anuj Gaggar.;Kathryn M Kitrinos.;G Mani Subramanian.;Patrick Marcellin.;Maria Buti.;Harry L A Janssen.;Ed Gane.;Vitina Sozzi.;Danni Colledge.;Rachel Hammond.;Rosalind Edwards.;Stephen Locarnini.;Alexander Thompson.;Peter A Revill.
来源: Gut. 2017年66卷11期2013-2023页
Hepatitis B e antigen (HBeAg) seroconversion and hepatitis B surface antigen (HBsAg) loss are important clinical outcomes for patients with chronic hepatitis B (CHB) treated with antiviral therapy. To date, there have been few studies that have evaluated viral sequence markers predicting serological response to nucleos(t)ide analogue (NA) treatment.
7. A randomised comparison of two faecal immunochemical tests in population-based colorectal cancer screening.
作者: E J Grobbee.;M van der Vlugt.;A J van Vuuren.;A K Stroobants.;M W Mundt.;W J Spijker.;E J C Bongers.;E J Kuipers.;I Lansdorp-Vogelaar.;P M Bossuyt.;E Dekker.;M C W Spaander.
来源: Gut. 2017年66卷11期1975-1982页
Colorectal cancer screening programmes are implemented worldwide; many are based on faecal immunochemical testing (FIT). The aim of this study was to evaluate two frequently used FITs on participation, usability, positivity rate and diagnostic yield in population-based FIT screening.
8. Full-spectrum (FUSE) versus standard forward-viewing colonoscopy in an organised colorectal cancer screening programme.
作者: Cesare Hassan.;Carlo Senore.;Franco Radaelli.;Giovanni De Pretis.;Romano Sassatelli.;Arrigo Arrigoni.;Gianpiero Manes.;Arnaldo Amato.;Andrea Anderloni.;Franco Armelao.;Alessandra Mondardini.;Cristiano Spada.;Barbara Omazzi.;Maurizio Cavina.;Gianni Miori.;Chiara Campanale.;Giuliana Sereni.;Nereo Segnan.;Alessandro Repici.
来源: Gut. 2017年66卷11期1949-1955页
Miss rate of polyps has been shown to be substantially lower with full-spectrum endoscopy (FUSE) compared with standard forward-viewing (SFV) colonoscopy in a tandem study at per polyp analysis. However, there is uncertainty on whether FUSE is also associated with a higher detection rate of colorectal neoplasia, especially advanced lesions, in per patient analysis.
9. Anti-NKG2D monoclonal antibody (NNC0142-0002) in active Crohn's disease: a randomised controlled trial.
作者: Matthieu Allez.;Brett E Skolnick.;Maria Wisniewska-Jarosinska.;Robert Petryka.;Rune Viig Overgaard.
来源: Gut. 2017年66卷11期1918-1925页
Anti-NKG2D (NNC0142-0002) is an antagonising human immunoglobulin G4 monoclonal antibody that binds to natural killer group 2 member D (NKG2D) receptors, which are expressed by T cells and innate lymphoid cells, and may be linked to mucosal damage in Crohn's disease (CD).
10. High prevalence of adenomatous colorectal polyps in young cancer survivors treated with abdominal radiation therapy: results of a prospective trial.
作者: Patricia E Daly.;Sara Samiee.;Maria Cino.;Robert Gryfe.;Aaron Pollett.;Andrea Ng.;Louis S Constine.;David C Hodgson.
来源: Gut. 2017年66卷10期1797-1801页
Cancer survivors treated with abdominal/pelvic radiation therapy (ART) have increased the risks of colorectal cancer (CRC), although evidence supporting early CRC screening for these patients is lacking. We sought to determine whether there is an elevated prevalence of adenomatous colorectal polyps in young survivors prior to the age when screening would be routinely recommended.
11. Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study.
作者: Jacqueline M Lankelma.;Duncan R Cranendonk.;Clara Belzer.;Alex F de Vos.;Willem M de Vos.;Tom van der Poll.;W Joost Wiersinga.
来源: Gut. 2017年66卷9期1623-1630页
The gut microbiota is essential for the development of the intestinal immune system. Animal models have suggested that the gut microbiota also acts as a major modulator of systemic innate immunity during sepsis. Microbiota disruption by broad-spectrum antibiotics could thus have adverse effects on cellular responsiveness towards invading pathogens. As such, the use of antibiotics may attribute to immunosuppression as seen in sepsis. We aimed to test whether disruption of the gut microbiota affects systemic innate immune responses during endotoxemia in healthy subjects.
12. Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial.
作者: Ankit Bhardwaj.;Chandan Kumar Kedarisetty.;Chitranshu Vashishtha.;Ajeet Singh Bhadoria.;Ankur Jindal.;Guresh Kumar.;Ashok Choudhary.;S M Shasthry.;Rakhi Maiwall.;Manoj Kumar.;Vikram Bhatia.;Shiv Kumar Sarin.
来源: Gut. 2017年66卷10期1838-1843页
Carvedilol is effective in the primary prophylaxis for large oesophageal varices. We investigated its use in preventing progression of small to large oesophageal varices.
13. Comparing CT colonography and flexible sigmoidoscopy: a randomised trial within a population-based screening programme.
作者: Daniele Regge.;Gabriella Iussich.;Nereo Segnan.;Loredana Correale.;Cesare Hassan.;Arrigo Arrigoni.;Roberto Asnaghi.;Piero Bestagini.;Gianmarco Bulighin.;Maria Carla Cassinis.;Andrea Ederle.;Andrea Ferraris.;Giovanni Galatola.;Teresa Gallo.;Giovanni Gandini.;Licia Garretti.;Maria Cristina Martina.;Daniela Molinar.;Stefania Montemezzi.;Lia Morra.;Massimiliano Motton.;Pietro Occhipinti.;Lucia Pinali.;Gian Alberto Soardi.;Carlo Senore.
来源: Gut. 2017年66卷8期1434-1440页
The role of CT colonography (CTC) as a colorectal cancer (CRC) screening test is uncertain. The aim of our trial was to compare participation and detection rate (DR) with sigmoidoscopy (flexible sigmoidoscopy (FS)) and CTC in a screening setting.
14. Narrow band imaging optical diagnosis of small colorectal polyps in routine clinical practice: the Detect Inspect Characterise Resect and Discard 2 (DISCARD 2) study.
作者: Colin J Rees.;Praveen T Rajasekhar.;Ana Wilson.;Helen Close.;Matthew D Rutter.;Brian P Saunders.;James E East.;Rebecca Maier.;Morgan Moorghen.;Usman Muhammad.;Helen Hancock.;Anthoor Jayaprakash.;Chris MacDonald.;Arvind Ramadas.;Anjan Dhar.;James M Mason.
来源: Gut. 2017年66卷5期887-895页
Accurate optical characterisation and removal of small adenomas (<10 mm) at colonoscopy would allow hyperplastic polyps to be left in situ and surveillance intervals to be determined without the need for histopathology. Although accurate in specialist practice the performance of narrow band imaging (NBI), colonoscopy in routine clinical practice is poorly understood.
15. The neurokinin-2 receptor antagonist ibodutant improves overall symptoms, abdominal pain and stool pattern in female patients in a phase II study of diarrhoea-predominant IBS.
作者: J Tack.;K Schumacher.;G Tonini.;S Scartoni.;A Capriati.;C A Maggi.; .
来源: Gut. 2017年66卷8期1403-1413页
Tachykinins have been implicated in the pathophysiology of IBS with diarrhoea (IBS-D). Our aim was to study the efficacy and safety of ibodutant, a selective neurokinin-2 (NK2) receptor antagonist, in patients with IBS-D.
16. FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial.
作者: Keith McIntosh.;David E Reed.;Theresa Schneider.;Frances Dang.;Ammar H Keshteli.;Giada De Palma.;Karen Madsen.;Premysl Bercik.;Stephen Vanner.
来源: Gut. 2017年66卷7期1241-1251页
To gain mechanistic insights, we compared effects of low fermentable oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high FODMAP diets on symptoms, the metabolome and the microbiome of patients with IBS.
17. Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, double-blind study.
作者: Kazunari Murakami.;Yuuichi Sakurai.;Madoka Shiino.;Nobuo Funao.;Akira Nishimura.;Masahiro Asaka.
来源: Gut. 2016年65卷9期1439-46页
The objective of this study was to assess the efficacy, safety and tolerability of vonoprazan, a novel potassium-competitive acid blocker, as a component of Helicobacter pylori eradication therapy.
18. Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD.
作者: Thomas Lee.;Thomas Clavel.;Kirill Smirnov.;Annemarie Schmidt.;Ilias Lagkouvardos.;Alesia Walker.;Marianna Lucio.;Bernhard Michalke.;Philippe Schmitt-Kopplin.;Richard Fedorak.;Dirk Haller.
来源: Gut. 2017年66卷5期863-871页
Iron deficiency is a common complication in patients with IBD and oral iron therapy is suggested to exacerbate IBD symptoms. We performed an open-labelled clinical trial to compare the effects of per oral (PO) versus intravenous (IV) iron replacement therapy (IRT).
19. A randomised trial of endoscopic submucosal dissection versus endoscopic mucosal resection for early Barrett's neoplasia.
作者: Grischa Terheggen.;Eva Maria Horn.;Michael Vieth.;Helmut Gabbert.;Markus Enderle.;Alexander Neugebauer.;Brigitte Schumacher.;Horst Neuhaus.
来源: Gut. 2017年66卷5期783-793页
For endoscopic resection of early GI neoplasia, endoscopic submucosal dissection (ESD) achieves higher rates of complete resection (R0) than endoscopic mucosal resection (EMR). However, ESD is technically more difficult and evidence from randomised trial is missing.
20. Adenoma detection with Endocuff colonoscopy versus conventional colonoscopy: a multicentre randomised controlled trial.
作者: S C van Doorn.;M van der Vlugt.;Actm Depla.;C A Wientjes.;R C Mallant-Hent.;P D Siersema.;Kmaj Tytgat.;H Tuynman.;S D Kuiken.;Gmp Houben.;Pcf Stokkers.;Lmg Moons.;Pmm Bossuyt.;P Fockens.;M W Mundt.;E Dekker.
来源: Gut. 2017年66卷3期438-445页
Colonoscopy is the current reference standard for the detection of colorectal neoplasia, but nevertheless adenomas remain undetected. The Endocuff, an endoscopic cap with plastic projections, may improve colonic visualisation and adenoma detection. The aim of this study was to compare the mean number of adenomas per patient (MAP) and the adenoma detection rate (ADR) between Endocuff-assisted colonoscopy (EAC) and conventional colonoscopy (CC).
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