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1872. Medical Therapies for Adult Chronic Sinusitis: A Systematic Review.
Chronic sinusitis is a common inflammatory condition defined by persistent symptomatic inflammation of the sinonasal cavities lasting longer than 3 months. It accounts for 1% to 2% of total physician encounters and is associated with large health care expenditures. Appropriate use of medical therapies for chronic sinusitis is necessary to optimize patient quality of life (QOL) and daily functioning and minimize the risk of acute inflammatory exacerbations.
1873. Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth.
作者: Rajen J Mody.;Yi-Mi Wu.;Robert J Lonigro.;Xuhong Cao.;Sameek Roychowdhury.;Pankaj Vats.;Kevin M Frank.;John R Prensner.;Irfan Asangani.;Nallasivam Palanisamy.;Jonathan R Dillman.;Raja M Rabah.;Laxmi Priya Kunju.;Jessica Everett.;Victoria M Raymond.;Yu Ning.;Fengyun Su.;Rui Wang.;Elena M Stoffel.;Jeffrey W Innis.;J Scott Roberts.;Patricia L Robertson.;Gregory Yanik.;Aghiad Chamdin.;James A Connelly.;Sung Choi.;Andrew C Harris.;Carrie Kitko.;Rama Jasty Rao.;John E Levine.;Valerie P Castle.;Raymond J Hutchinson.;Moshe Talpaz.;Dan R Robinson.;Arul M Chinnaiyan.
来源: JAMA. 2015年314卷9期913-25页
Cancer is caused by a diverse array of somatic and germline genomic aberrations. Advances in genomic sequencing technologies have improved the ability to detect these molecular aberrations with greater sensitivity. However, integrating them into clinical management in an individualized manner has proven challenging.
1874. Association Between Blood Pressure Control and Risk of Recurrent Intracerebral Hemorrhage.
作者: Alessandro Biffi.;Christopher D Anderson.;Thomas W K Battey.;Alison M Ayres.;Steven M Greenberg.;Anand Viswanathan.;Jonathan Rosand.
来源: JAMA. 2015年314卷9期904-12页
Intracerebral hemorrhage (ICH) is the most severe form of stroke. Survivors are at high risk of recurrence, death, and worsening functional disability.
1875. Molecular Diagnostic Yield of Chromosomal Microarray Analysis and Whole-Exome Sequencing in Children With Autism Spectrum Disorder.
作者: Kristiina Tammimies.;Christian R Marshall.;Susan Walker.;Gaganjot Kaur.;Bhooma Thiruvahindrapuram.;Anath C Lionel.;Ryan K C Yuen.;Mohammed Uddin.;Wendy Roberts.;Rosanna Weksberg.;Marc Woodbury-Smith.;Lonnie Zwaigenbaum.;Evdokia Anagnostou.;Zhuozhi Wang.;John Wei.;Jennifer L Howe.;Matthew J Gazzellone.;Lynette Lau.;Wilson W L Sung.;Kathy Whitten.;Cathy Vardy.;Victoria Crosbie.;Brian Tsang.;Lia D'Abate.;Winnie W L Tong.;Sandra Luscombe.;Tyna Doyle.;Melissa T Carter.;Peter Szatmari.;Susan Stuckless.;Daniele Merico.;Dimitri J Stavropoulos.;Stephen W Scherer.;Bridget A Fernandez.
来源: JAMA. 2015年314卷9期895-903页
The use of genome-wide tests to provide molecular diagnosis for individuals with autism spectrum disorder (ASD) requires more study.
1876. Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy: A Randomized Clinical Trial.
作者: George L Bakris.;Rajiv Agarwal.;Juliana C Chan.;Mark E Cooper.;Ron T Gansevoort.;Hermann Haller.;Giuseppe Remuzzi.;Peter Rossing.;Roland E Schmieder.;Christina Nowack.;Peter Kolkhof.;Amer Joseph.;Alexander Pieper.;Nina Kimmeskamp-Kirschbaum.;Luis M Ruilope.; .
来源: JAMA. 2015年314卷9期884-94页
Steroidal mineralocorticoid receptor antagonists, when added to a renin-angiotensin system blocker, further reduce proteinuria in patients with chronic kidney disease but may be underused because of a high risk of adverse events.
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