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166. Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease.
作者: William R Hiatt.;F Gerry R Fowkes.;Gretchen Heizer.;Jeffrey S Berger.;Iris Baumgartner.;Peter Held.;Brian G Katona.;Kenneth W Mahaffey.;Lars Norgren.;W Schuyler Jones.;Juuso Blomster.;Marcus Millegård.;Craig Reist.;Manesh R Patel.; .
来源: N Engl J Med. 2017年376卷1期32-40页
Peripheral artery disease is considered to be a manifestation of systemic atherosclerosis with associated adverse cardiovascular and limb events. Data from previous trials have suggested that patients receiving clopidogrel monotherapy had a lower risk of cardiovascular events than those receiving aspirin. We wanted to compare clopidogrel with ticagrelor, a potent antiplatelet agent, in patients with peripheral artery disease.
167. Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
作者: Steven E Nissen.;Neville D Yeomans.;Daniel H Solomon.;Thomas F Lüscher.;Peter Libby.;M Elaine Husni.;David Y Graham.;Jeffrey S Borer.;Lisa M Wisniewski.;Katherine E Wolski.;Qiuqing Wang.;Venu Menon.;Frank Ruschitzka.;Michael Gaffney.;Bruce Beckerman.;Manuela F Berger.;Weihang Bao.;A Michael Lincoff.; .
来源: N Engl J Med. 2016年375卷26期2519-29页
The cardiovascular safety of celecoxib, as compared with nonselective nonsteroidal antiinflammatory drugs (NSAIDs), remains uncertain.
168. A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.
作者: Kevin Fitzgerald.;Suellen White.;Anna Borodovsky.;Brian R Bettencourt.;Andrew Strahs.;Valerie Clausen.;Peter Wijngaard.;Jay D Horton.;Jorg Taubel.;Ashley Brooks.;Chamikara Fernando.;Robert S Kauffman.;David Kallend.;Akshay Vaishnaw.;Amy Simon.
来源: N Engl J Med. 2017年376卷1期41-51页
Inclisiran (ALN-PCSsc) is a long-acting RNA interference (RNAi) therapeutic agent that inhibits the synthesis of proprotein convertase subtilisin-kexin type 9 (PCSK9), a target for the lowering of low-density lipoprotein (LDL) cholesterol.
169. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease.
作者: Amit V Khera.;Connor A Emdin.;Isabel Drake.;Pradeep Natarajan.;Alexander G Bick.;Nancy R Cook.;Daniel I Chasman.;Usman Baber.;Roxana Mehran.;Daniel J Rader.;Valentin Fuster.;Eric Boerwinkle.;Olle Melander.;Marju Orho-Melander.;Paul M Ridker.;Sekar Kathiresan.
来源: N Engl J Med. 2016年375卷24期2349-2358页
Both genetic and lifestyle factors contribute to individual-level risk of coronary artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle is unknown.
170. Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI.
作者: C Michael Gibson.;Roxana Mehran.;Christoph Bode.;Jonathan Halperin.;Freek W Verheugt.;Peter Wildgoose.;Mary Birmingham.;Juliana Ianus.;Paul Burton.;Martin van Eickels.;Serge Korjian.;Yazan Daaboul.;Gregory Y H Lip.;Marc Cohen.;Steen Husted.;Eric D Peterson.;Keith A Fox.
来源: N Engl J Med. 2016年375卷25期2423-2434页
In patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) with placement of stents, standard anticoagulation with a vitamin K antagonist plus dual antiplatelet therapy (DAPT) with a P2Y12 inhibitor and aspirin reduces the risk of thrombosis and stroke but increases the risk of bleeding. The effectiveness and safety of anticoagulation with rivaroxaban plus either one or two antiplatelet agents are uncertain.
171. Randomized Trial of Bilateral versus Single Internal-Thoracic-Artery Grafts.
作者: David P Taggart.;Douglas G Altman.;Alastair M Gray.;Belinda Lees.;Stephen Gerry.;Umberto Benedetto.;Marcus Flather.; .
来源: N Engl J Med. 2016年375卷26期2540-9页
The use of bilateral internal thoracic (mammary) arteries for coronary-artery bypass grafting (CABG) may improve long-term outcomes as compared with the use of a single internal-thoracic-artery plus vein grafts.
174. A Fully Magnetically Levitated Circulatory Pump for Advanced Heart Failure.
作者: Mandeep R Mehra.;Yoshifumi Naka.;Nir Uriel.;Daniel J Goldstein.;Joseph C Cleveland.;Paolo C Colombo.;Mary N Walsh.;Carmelo A Milano.;Chetan B Patel.;Ulrich P Jorde.;Francis D Pagani.;Keith D Aaronson.;David A Dean.;Kelly McCants.;Akinobu Itoh.;Gregory A Ewald.;Douglas Horstmanshof.;James W Long.;Christopher Salerno.; .
来源: N Engl J Med. 2017年376卷5期440-450页
Continuous-flow left ventricular assist systems increase the rate of survival among patients with advanced heart failure but are associated with the development of pump thrombosis. We investigated the effects of a new magnetically levitated centrifugal continuous-flow pump that was engineered to avert thrombosis.
176. Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults.
作者: Ahmad Kaddourah.;Rajit K Basu.;Sean M Bagshaw.;Stuart L Goldstein.; .
来源: N Engl J Med. 2017年376卷1期11-20页
The epidemiologic characteristics of children and young adults with acute kidney injury have been described in single-center and retrospective studies. We conducted a multinational, prospective study involving patients admitted to pediatric intensive care units to define the incremental risk of death and complications associated with severe acute kidney injury.
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