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141. Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma.
作者: Matthew F Buas.;Qianchuan He.;Lisa G Johnson.;Lynn Onstad.;David M Levine.;Aaron P Thrift.;Puya Gharahkhani.;Claire Palles.;Jesper Lagergren.;Rebecca C Fitzgerald.;Weimin Ye.;Carlos Caldas.;Nigel C Bird.;Nicholas J Shaheen.;Leslie Bernstein.;Marilie D Gammon.;Anna H Wu.;Laura J Hardie.;Paul D Pharoah.;Geoffrey Liu.;Prassad Iyer.;Douglas A Corley.;Harvey A Risch.;Wong-Ho Chow.;Hans Prenen.;Laura Chegwidden.;Sharon Love.;Stephen Attwood.;Paul Moayyedi.;David MacDonald.;Rebecca Harrison.;Peter Watson.;Hugh Barr.;John deCaestecker.;Ian Tomlinson.;Janusz Jankowski.;David C Whiteman.;Stuart MacGregor.;Thomas L Vaughan.;Margaret M Madeleine.
来源: Gut. 2017年66卷10期1739-1747页
Oesophageal adenocarcinoma (OA) incidence has risen sharply in Western countries over recent decades. Local and systemic inflammation is considered an important contributor to OA pathogenesis. Established risk factors for OA and its precursor, Barrett's oesophagus (BE), include symptomatic reflux, obesity and smoking. The role of inherited genetic susceptibility remains an area of active investigation. Here, we explore whether germline variation related to inflammatory processes influences susceptibility to BE/OA.
142. A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency.
作者: Soesma A Jankipersadsing.;Fatemeh Hadizadeh.;Marc Jan Bonder.;Ettje F Tigchelaar.;Patrick Deelen.;Jingyuan Fu.;Anna Andreasson.;Lars Agreus.;Susanna Walter.;Cisca Wijmenga.;Pirro Hysi.;Mauro D'Amato.;Alexandra Zhernakova.
来源: Gut. 2017年66卷4期756-758页 143. Unique pathology of colonic spirochaetosis characterised by mucosal eosinophilia is linked to diarrhoea and IBS.
作者: Thomas M Goodsall.;Nicholas J Talley.;Loui Rassam.;Nicola K Wood.;Alkesh Zala.;Mike Jones.;Marjorie M Walker.
来源: Gut. 2017年66卷5期978-979页 145. Deep mural injury and perforation after colonic endoscopic mucosal resection: a new classification and analysis of risk factors.
作者: Nicholas G Burgess.;Milan S Bassan.;Duncan McLeod.;Stephen J Williams.;Karen Byth.;Michael J Bourke.
来源: Gut. 2017年66卷10期1779-1789页
Perforation is the most serious complication associated with endoscopic mucosal resection (EMR). We propose a new classification for the appearance and integrity of the muscularis propria (MP) after EMR including various extents of deep mural injury (DMI). Risk factors for these injuries were analysed.
146. Epithelial NEMO/IKKγ limits fibrosis and promotes regeneration during pancreatitis.
作者: Lap Kwan Chan.;Melanie Gerstenlauer.;Björn Konukiewitz.;Katja Steiger.;Wilko Weichert.;Thomas Wirth.;Harald Jakob Maier.
来源: Gut. 2017年66卷11期1995-2007页
Inhibitory κB kinase (IKK)/nuclear factor κB (NF-κB) signalling has been implicated in the pathogenesis of pancreatitis, but its precise function has remained controversial. Here, we analyse the contribution of IKK/NF-κB signalling in epithelial cells to the pathogenesis of pancreatitis by targeting the IKK subunit NF-κB essential modulator (NEMO) (IKKγ), which is essential for canonical NF-κB activation.
148. Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease.
作者: Melanie Uhde.;Mary Ajamian.;Giacomo Caio.;Roberto De Giorgio.;Alyssa Indart.;Peter H Green.;Elizabeth C Verna.;Umberto Volta.;Armin Alaedini.
来源: Gut. 2016年65卷12期1930-1937页
Wheat gluten and related proteins can trigger an autoimmune enteropathy, known as coeliac disease, in people with genetic susceptibility. However, some individuals experience a range of symptoms in response to wheat ingestion, without the characteristic serological or histological evidence of coeliac disease. The aetiology and mechanism of these symptoms are unknown, and no biomarkers have been identified. We aimed to determine if sensitivity to wheat in the absence of coeliac disease is associated with systemic immune activation that may be linked to an enteropathy.
149. Reassuring results on birth outcomes in children fathered by men treated with azathioprine/6-mercaptopurine within 3 months before conception: a nationwide cohort study.
Information on the safety of paternal use of azathioprine (AZA) and 6-mercaptopurine (6-MP) prior to conception is limited. Based on nationwide data from the Danish health registries, we examined the association between paternal use of AZA/6-MP within 3 months before conception and adverse birth outcomes.
150. Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.
作者: Fanny Grillet.;Elsa Bayet.;Olivia Villeronce.;Luke Zappia.;Ebba Louise Lagerqvist.;Sebastian Lunke.;Emmanuelle Charafe-Jauffret.;Kym Pham.;Christina Molck.;Nathalie Rolland.;Jean François Bourgaux.;Michel Prudhomme.;Claire Philippe.;Sophie Bravo.;Jean Christophe Boyer.;Lucile Canterel-Thouennon.;Graham Roy Taylor.;Arthur Hsu.;Jean Marc Pascussi.;Frédéric Hollande.;Julie Pannequin.
来源: Gut. 2017年66卷10期1802-1810页
Although counting of circulating tumour cells (CTC) has attracted a broad interest as potential markers of tumour progression and treatment response, the lack of functional characterisation of these cells had become a bottleneck in taking these observations to the clinic. Our objective was to culture these cells in order to understand them and exploit their therapeutic potential to the full.
152. Marine ω-3 polyunsaturated fatty acid intake and survival after colorectal cancer diagnosis.
作者: Mingyang Song.;Xuehong Zhang.;Jeffrey A Meyerhardt.;Edward L Giovannucci.;Shuji Ogino.;Charles S Fuchs.;Andrew T Chan.
来源: Gut. 2017年66卷10期1790-1796页
Experimental evidence supports an antineoplastic activity of marine ω-3 polyunsaturated fatty acids (ω-3 PUFAs; including eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid). However, the influence of ω-3 PUFAs on colorectal cancer (CRC) survival is unknown.
154. Highly bioavailable silibinin nanoparticles inhibit HCV infection.
作者: Ching-Hsuan Liu.;Chun-Ching Lin.;Wen-Chan Hsu.;Chueh-Yao Chung.;Chih-Chan Lin.;Alagie Jassey.;Shun-Pang Chang.;Chen-Jei Tai.;Cheng-Jeng Tai.;Justin Shields.;Christopher D Richardson.;Ming-Hong Yen.;D Lorne J Tyrrell.;Liang-Tzung Lin.
来源: Gut. 2017年66卷10期1853-1861页
Silibinin is a flavonolignan that is well established for its robust antiviral activity against HCV infection and has undergone several clinical trials for the management of hepatitis C. Despite its potency, silibinin suffers from poor solubility and bioavailability, restricting its clinical use. To overcome this limitation, we developed highly bioavailable silibinin nanoparticles (SB-NPs) and evaluated their efficiency against HCV infection.
156. Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis.
作者: Carl-Philipp Hackstein.;Lisa Mareike Assmus.;Meike Welz.;Sabine Klein.;Timo Schwandt.;Joachim Schultze.;Irmgard Förster.;Fabian Gondorf.;Marc Beyer.;Daniela Kroy.;Christian Kurts.;Jonel Trebicka.;Wolfgang Kastenmüller.;Percy A Knolle.;Zeinab Abdullah.
来源: Gut. 2017年66卷3期507-518页
Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity.
157. Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms.
作者: Jun Yu.;Yoshihiko Sadakari.;Koji Shindo.;Masaya Suenaga.;Aaron Brant.;Jose Alejandro Navarro Almario.;Michael Borges.;Thomas Barkley.;Shahriar Fesharakizadeh.;Madeline Ford.;Ralph H Hruban.;Eun Ji Shin.;Anne Marie Lennon.;Marcia Irene Canto.;Michael Goggins.
来源: Gut. 2017年66卷9期1677-1687页
Secretin-stimulated pancreatic juice contains DNA shed from cells lining the pancreatic ducts. Genetic analysis of this fluid may form a test to detect pancreatic ductal neoplasia.
158. Effectiveness and safety of sofosbuvir plus ribavirin for the treatment of HCV genotype 2 infection: results of the real-world, clinical practice HCV-TARGET study.
作者: Tania M Welzel.;David R Nelson.;Giuseppe Morelli.;Adrian Di Bisceglie.;Rajender K Reddy.;Alexander Kuo.;Joseph K Lim.;Jama Darling.;Paul Pockros.;Joseph S Galati.;Lynn M Frazier.;Saleh Alqahtani.;Mark S Sulkowski.;Monika Vainorius.;Lucy Akushevich.;Michael W Fried.;Stefan Zeuzem.; .
来源: Gut. 2017年66卷10期1844-1852页
Due to a high efficacy in clinical trials, sofosbuvir (SOF) and ribavirin (RBV) for 12 or 16 weeks is recommended for treatment of patients with HCV genotype (GT) 2 infection. We investigated safety and effectiveness of these regimens for GT2 in HCV-TARGET participants.
159. High prevalence of adenomatous colorectal polyps in young cancer survivors treated with abdominal radiation therapy: results of a prospective trial.
作者: Patricia E Daly.;Sara Samiee.;Maria Cino.;Robert Gryfe.;Aaron Pollett.;Andrea Ng.;Louis S Constine.;David C Hodgson.
来源: Gut. 2017年66卷10期1797-1801页
Cancer survivors treated with abdominal/pelvic radiation therapy (ART) have increased the risks of colorectal cancer (CRC), although evidence supporting early CRC screening for these patients is lacking. We sought to determine whether there is an elevated prevalence of adenomatous colorectal polyps in young survivors prior to the age when screening would be routinely recommended.
160. Colonic microbiota can promote rapid local improvement of murine colitis by thioguanine independently of T lymphocytes and host metabolism.
作者: I Oancea.;R Movva.;I Das.;D Aguirre de Cárcer.;V Schreiber.;Y Yang.;A Purdon.;B Harrington.;M Proctor.;R Wang.;Y Sheng.;M Lobb.;R Lourie.;P Ó Cuív.;J A Duley.;J Begun.;T H J Florin.
来源: Gut. 2017年66卷1期59-69页
Mercaptopurine (MP) and pro-drug azathioprine are 'first-line' oral therapies for maintaining remission in IBD. It is believed that their pharmacodynamic action is due to a slow cumulative decrease in activated lymphocytes homing to inflamed gut. We examined the role of host metabolism, lymphocytes and microbiome for the amelioration of colitis by the related thioguanine (TG).
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