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144. Association Between Poorer Cognitive Function and Reduced Objectively Monitored Medication Adherence in Patients With Heart Failure.
作者: Mary A Dolansky.;Misty A W Hawkins.;Julie T Schaefer.;Abdus Sattar.;John Gunstad.;Joseph D Redle.;Richard Josephson.;Shirley M Moore.;Joel W Hughes.
来源: Circ Heart Fail. 2016年9卷12期
Subclinical cognitive impairment is prevalent in heart failure (HF); however, its role in important clinical outcomes, such as HF treatment adherence, is unclear. Given the complex polypharmacy in HF treatment, cognitive deficits may be important in predicting medication management. Thus, the objective of the current study was to examine the impact of cognitive function on medication adherence among community-dwelling patients with HF using objective assessments.
146. Response by Fordyce et al to Letter Regarding Article, "On-Treatment Outcomes in Patients With Worsening Renal Function With Rivaroxaban Compared With Warfarin: Insights From ROCKET AF".
作者: Christopher B Fordyce.;Jonathan P Piccini.;Manesh R Patel.
来源: Circulation. 2016年134卷22期e532-e533页 147. Letter by Escobar et al Regarding Article, "On-Treatment Outcomes in Patients With Worsening Renal Function With Rivaroxaban Compared With Warfarin: Insights From ROCKET AF".148. Impact of Body Mass Index on the Accuracy of N-Terminal Pro-Brain Natriuretic Peptide and Brain Natriuretic Peptide for Predicting Outcomes in Patients With Chronic Heart Failure and Reduced Ejection Fraction: Insights From the PARADIGM-HF Study (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial).
作者: Wilson Nadruz.;Brian L Claggett.;John J McMurray.;Milton Packer.;Michael R Zile.;Jean L Rouleau.;Akshay S Desai.;Karl Swedberg.;Martin Lefkowitz.;Victor C Shi.;Margaret F Prescott.;Scott D Solomon.
来源: Circulation. 2016年134卷22期1785-1787页 149. Medical Treatment of Aortic Stenosis.
作者: Guillaume Marquis-Gravel.;Björn Redfors.;Martin B Leon.;Philippe Généreux.
来源: Circulation. 2016年134卷22期1766-1784页
Untreated, severe, symptomatic aortic stenosis is associated with a dismal prognosis. The only treatment shown to improve survival is aortic valve replacement; however, before symptoms occur, aortic stenosis is preceded by a silent, latent phase characterized by a slow progression at the molecular, cellular, and tissue levels. In theory, specific medical therapy should halt aortic stenosis progression, reduce its hemodynamic repercussions on left ventricular function and remodeling, and improve clinical outcomes. In the present report, we performed a systematic review of studies focusing on the medical treatment of patients with aortic stenosis. Lipid-lowering therapy, antihypertensive drugs, and anticalcific therapy have been the main drug classes studied in this setting and are reviewed in depth. A critical appraisal of the preclinical and clinical evidence is provided, and future research avenues are presented.
155. The STRATEGY Study (Stress Cardiac Magnetic Resonance Versus Computed Tomography Coronary Angiography for the Management of Symptomatic Revascularized Patients): Resources and Outcomes Impact.
作者: Gianluca Pontone.;Daniele Andreini.;Andrea I Guaricci.;Cristina Rota.;Marco Guglielmo.;Saima Mushtaq.;Andrea Baggiano.;Virginia Beltrama.;Laura Fusini.;Anna Solbiati.;Chiara Segurini.;Edoardo Conte.;Paola Gripari.;Andrea Annoni.;Alberto Formenti.;Maria Petulla'.;Federico Lombardi.;Giuseppe Muscogiuri.;Antonio L Bartorelli.;Mauro Pepi.
来源: Circ Cardiovasc Imaging. 2016年9卷10期
Computed tomography coronary angiography (cTCA) and stress cardiac magnetic resonance (stress-CMR) are suitable tools for diagnosing obstructive coronary artery disease in symptomatic patients with previous history of revascularization. However, performance appraisal of noninvasive tests must take in account the consequent diagnostic testing, invasive procedures, clinical outcomes, radiation exposure, and cumulative costs rather than their diagnostic accuracy only. We aimed to compare an anatomic (cTCA) versus a functional (stress-CMR) strategy in symptomatic patients with previous myocardial revascularization procedures.
156. Association Between Left Atrial Dilatation and Invasive Hemodynamics at Rest and During Exercise in Asymptomatic Aortic Stenosis.
作者: Nicolaj Lyhne Christensen.;Jordi Sanchez Dahl.;Rasmus Carter-Storch.;Rine Bakkestrøm.;Kurt Jensen.;Flemming Hald Steffensen.;Eva Vad Søndergaard.;Lars Videbæk.;Jacob Eifer Møller.
来源: Circ Cardiovasc Imaging. 2016年9卷10期
Transition from an asymptomatic to symptomatic state in severe aortic stenosis is often difficult to assess. Identification of a morphological sign of increased hemodynamic load may be important in asymptomatic aortic stenosis to identify patients at risk.
157. Residual Myocardial Iron Following Intramyocardial Hemorrhage During the Convalescent Phase of Reperfused ST-Segment-Elevation Myocardial Infarction and Adverse Left Ventricular Remodeling.
作者: Heerajnarain Bulluck.;Stefania Rosmini.;Amna Abdel-Gadir.;Steven K White.;Anish N Bhuva.;Thomas A Treibel.;Marianna Fontana.;Manish Ramlall.;Ashraf Hamarneh.;Alex Sirker.;Anna S Herrey.;Charlotte Manisty.;Derek M Yellon.;Peter Kellman.;James C Moon.;Derek J Hausenloy.
来源: Circ Cardiovasc Imaging. 2016年9卷10期e004940页
The presence of intramyocardial hemorrhage (IMH) in ST-segment-elevation myocardial infarction patients reperfused by primary percutaneous coronary intervention has been associated with residual myocardial iron at follow-up, and its impact on adverse left ventricular (LV) remodeling is incompletely understood and is investigated here.
158. Excess Cardiovascular Risk in Women Relative to Men Referred for Coronary Angiography Is Associated With Severely Impaired Coronary Flow Reserve, Not Obstructive Disease.
作者: Viviany R Taqueti.;Leslee J Shaw.;Nancy R Cook.;Venkatesh L Murthy.;Nishant R Shah.;Courtney R Foster.;Jon Hainer.;Ron Blankstein.;Sharmila Dorbala.;Marcelo F Di Carli.
来源: Circulation. 2017年135卷6期566-577页
Cardiovascular disease (CVD) fatality rates are higher for women than for men, yet obstructive coronary artery disease (CAD) is less prevalent in women. Coronary flow reserve (CFR), an integrated measure of large- and small-vessel CAD and myocardial ischemia, identifies patients at risk for CVD death, but is not routinely measured in clinical practice. We sought to investigate the impact of sex, CFR, and angiographic CAD severity on adverse cardiovascular events.
159. Extended-Duration Betrixaban Reduces the Risk of Stroke Versus Standard-Dose Enoxaparin Among Hospitalized Medically Ill Patients: An APEX Trial Substudy (Acute Medically Ill Venous Thromboembolism Prevention With Extended Duration Betrixaban).
作者: C Michael Gibson.;Gerald Chi.;Rim Halaby.;Serge Korjian.;Yazan Daaboul.;Purva Jain.;Douglas Arbetter.;Samuel Z Goldhaber.;Russel Hull.;Adrian F Hernandez.;Alex Gold.;Olga Bandman.;Robert A Harrington.;Alexander T Cohen.; .
来源: Circulation. 2017年135卷7期648-655页
Stroke is a morbid and potentially mortal complication among patients hospitalized with acute medical illness. The potential of extended-duration thromboprophylaxis with the factor Xa inhibitor betrixaban to reduce the risk of stroke compared with standard-dose enoxaparin in this population was assessed in this retrospective APEX trial substudy (Acute Medically Ill Venous Thromboembolism Prevention With Extended Duration Betrixaban).
160. Incident Type 2 Myocardial Infarction in a Cohort of Patients Undergoing Coronary or Peripheral Arterial Angiography.
作者: Hanna K Gaggin.;Yuyin Liu.;Asya Lyass.;Roland R J van Kimmenade.;Shweta R Motiwala.;Noreen P Kelly.;Aditi Mallick.;Parul U Gandhi.;Nasrien E Ibrahim.;Mandy L Simon.;Anju Bhardwaj.;Arianna M Belcher.;Jamie E Harisiades.;Joseph M Massaro.;Ralph B D'Agostino.;James L Januzzi.
来源: Circulation. 2017年135卷2期116-127页
Despite growing recognition of type 2 myocardial infarction (T2MI; related to supply/demand mismatch), little is known about its risk factors or its association with outcome.
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