当前位置: 首页 >> 检索结果
1451. Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
作者: Lorelei A Mucci.;Jacob B Hjelmborg.;Jennifer R Harris.;Kamila Czene.;David J Havelick.;Thomas Scheike.;Rebecca E Graff.;Klaus Holst.;Sören Möller.;Robert H Unger.;Christina McIntosh.;Elizabeth Nuttall.;Ingunn Brandt.;Kathryn L Penney.;Mikael Hartman.;Peter Kraft.;Giovanni Parmigiani.;Kaare Christensen.;Markku Koskenvuo.;Niels V Holm.;Kauko Heikkilä.;Eero Pukkala.;Axel Skytthe.;Hans-Olov Adami.;Jaakko Kaprio.; .
来源: JAMA. 2016年315卷1期68-76页
Estimates of familial cancer risk from population-based studies are essential components of cancer risk prediction.
1452. Association Between Use of Oral Fluconazole During Pregnancy and Risk of Spontaneous Abortion and Stillbirth.
作者: Ditte Mølgaard-Nielsen.;Henrik Svanström.;Mads Melbye.;Anders Hviid.;Björn Pasternak.
来源: JAMA. 2016年315卷1期58-67页
Vaginal candidiasis is common during pregnancy. Although intravaginal formulations of topical azole antifungals are first-line treatment for pregnant women, oral fluconazole is often used despite limited safety information.
1453. Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records.
作者: Sara L Van Driest.;Quinn S Wells.;Sarah Stallings.;William S Bush.;Adam Gordon.;Deborah A Nickerson.;Jerry H Kim.;David R Crosslin.;Gail P Jarvik.;David S Carrell.;James D Ralston.;Eric B Larson.;Suzette J Bielinski.;Janet E Olson.;Zi Ye.;Iftikhar J Kullo.;Noura S Abul-Husn.;Stuart A Scott.;Erwin Bottinger.;Berta Almoguera.;John Connolly.;Rosetta Chiavacci.;Hakon Hakonarson.;Laura J Rasmussen-Torvik.;Vivian Pan.;Stephen D Persell.;Maureen Smith.;Rex L Chisholm.;Terrie E Kitchner.;Max M He.;Murray H Brilliant.;John R Wallace.;Kimberly F Doheny.;M Benjamin Shoemaker.;Rongling Li.;Teri A Manolio.;Thomas E Callis.;Daniela Macaya.;Marc S Williams.;David Carey.;Jamie D Kapplinger.;Michael J Ackerman.;Marylyn D Ritchie.;Joshua C Denny.;Dan M Roden.
来源: JAMA. 2016年315卷1期47-57页
Large-scale DNA sequencing identifies incidental rare variants in established Mendelian disease genes, but the frequency of related clinical phenotypes in unselected patient populations is not well established. Phenotype data from electronic medical records (EMRs) may provide a resource to assess the clinical relevance of rare variants.
1454. Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
作者: Dalane W Kitzman.;Peter Brubaker.;Timothy Morgan.;Mark Haykowsky.;Gregory Hundley.;William E Kraus.;Joel Eggebeen.;Barbara J Nicklas.
来源: JAMA. 2016年315卷1期36-46页
More than 80% of patients with heart failure with preserved ejection fraction (HFPEF), the most common form of heart failure among older persons, are overweight or obese. Exercise intolerance is the primary symptom of chronic HFPEF and a major determinant of reduced quality of life (QOL).
|