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122. Agreement Between Rectosigmoidoscopy and Colonoscopy Analyses of Disease Activity and Healing in Patients With Ulcerative Colitis.
作者: Jean-Frédéric Colombel.;Ingrid Ordás.;Thomas Ullman.;Paul Rutgeerts.;Akiko Chai.;Sharon O'Byrne.;Timothy T Lu.;Julián Panés.
来源: Gastroenterology. 2016年150卷2期389-95.e3页
Endoscopy limited to the rectosigmoid colon is the standard technique used to measure endoscopic healing in ulcerative colitis (UC) clinical trials. We evaluated whether rectosigmoidoscopy adequately measures UC activity in the more proximal colon.
124. Aging of Liver Transplant Registrants and Recipients: Trends and Impact on Waitlist Outcomes, Post-Transplantation Outcomes, and Transplant-Related Survival Benefit.
作者: Feng Su.;Lei Yu.;Kristin Berry.;Iris W Liou.;Charles S Landis.;Stephen C Rayhill.;Jorge D Reyes.;George N Ioannou.
来源: Gastroenterology. 2016年150卷2期441-53.e6; quiz e16页
Epidemiologic factors have generated increased demand for liver transplantation among older patients. We aimed to describe trends in age among liver transplant registrants and recipients and the effect of age on waitlist and post-transplantation outcomes and on transplant-related survival benefit.
125. Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis.
作者: Gaik W Tew.;Jason A Hackney.;Deena Gibbons.;Christopher A Lamb.;Diana Luca.;Jackson G Egen.;Lauri Diehl.;Jeff Eastham Anderson.;Severine Vermeire.;John C Mansfield.;Brian G Feagan.;Julian Panes.;Daniel C Baumgart.;Stefan Schreiber.;Iris Dotan.;William J Sandborn.;John A Kirby.;Peter M Irving.;Gert De Hertogh.;Gert A Van Assche.;Paul Rutgeerts.;Sharon O'Byrne.;Adrian Hayday.;Mary E Keir.
来源: Gastroenterology. 2016年150卷2期477-87.e9页
Etrolizumab is a humanized monoclonal antibody against the β7 integrin subunit that has shown efficacy vs placebo in patients with moderate to severely active ulcerative colitis (UC). Patients with colon tissues that expressed high levels of the integrin αE gene (ITGAE) appeared to have the best response. We compared differences in colonic expression of ITGAE and other genes between patients who achieved clinical remission with etrolizumab vs those who did.
126. Real-Time Characterization of Diminutive Colorectal Polyp Histology Using Narrow-Band Imaging: Implications for the Resect and Discard Strategy.
作者: Swati G Patel.;Philip Schoenfeld.;Hyungjin Myra Kim.;Emily K Ward.;Ajay Bansal.;Yeonil Kim.;Lindsay Hosford.;Aimee Myers.;Stephanie Foster.;Jenna Craft.;Samuel Shopinski.;Robert H Wilson.;Dennis J Ahnen.;Amit Rastogi.;Sachin Wani.
来源: Gastroenterology. 2016年150卷2期406-18页
Narrow-band imaging (NBI) allows real-time histologic classification of colorectal polyps. We investigated whether endoscopists without prior training in NBI can achieve the following thresholds recommended by the American Society for Gastrointestinal Endoscopy: for diminutive colorectal polyps characterized with high confidence, a ≥90% negative predictive value for adenomas in the rectosigmoid and a ≥90% agreement in surveillance intervals.
127. The Updated Model: An Adjusted Serum Alpha-Fetoprotein-Based Algorithm for Hepatocellular Carcinoma Detection With Hepatitis C Virus-Related Cirrhosis.
作者: Donna L White.;Peter Richardson.;Nabiha Tayoub.;Jessica A Davila.;Fasiha Kanwal.;Hashem B El-Serag.
来源: Gastroenterology. 2015年149卷7期1986-7页 128. Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats.
作者: Michael D Roberts.;C Brooks Mobley.;Ryan G Toedebush.;Alexander J Heese.;Conan Zhu.;Anna E Krieger.;Clayton L Cruthirds.;Christopher M Lockwood.;John C Hofheins.;Charles E Wiedmeyer.;Heather J Leidy.;Frank W Booth.;R Scott Rector.
来源: BMC Gastroenterol. 2015年15卷151页
The purpose of this study was to investigate the effects of sub-chronic high fat, high sucrose diet (also termed 'Westernized diet' or WD) feeding on the liver transcriptome during early nonalcoholic fatty liver disease (NAFLD) development.
129. Intestinal Gas Capsules: A Proof-of-Concept Demonstration.
作者: Kourosh Kalantar-Zadeh.;Chu K Yao.;Kyle J Berean.;Nam Ha.;Jian Zhen Ou.;Stephanie A Ward.;Naresh Pillai.;Julian Hill.;Jeremy J Cottrell.;Frank R Dunshea.;Chris McSweeney.;Jane G Muir.;Peter R Gibson.
来源: Gastroenterology. 2016年150卷1期37-9页 130. The gut microbiome as a target for regulatory T cell-based immunotherapy: induction of regulatory lymphocytes by oral administration of anti-LPS enriched colostrum alleviates immune mediated colitis.
作者: Ami Ben Ya'acov.;Yoav Lichtenstein.;Lidya Zolotarov.;Yaron Ilan.
来源: BMC Gastroenterol. 2015年15卷154页
Gut-derived bacterial endotoxin is an important cofactor in the pathogenesis of IBD. Regulatory T cells (Tregs) are essential for maintenance of peripheral tolerance and can prevent and alleviate IBD. To determine the immune modulatory effect of anti-LPS enriched hyperimmune colostrum, its ability to induce Tregs and alleviate immune mediated colitis.
135. Xyloglucan for the treatment of acute diarrhea: results of a randomized, controlled, open-label, parallel group, multicentre, national clinical trial.
作者: Lucio Gnessi.;Vladimir Bacarea.;Marius Marusteri.;Núria Piqué.
来源: BMC Gastroenterol. 2015年15卷153页
There is a strong rationale for the use of agents with film-forming protective properties, like xyloglucan, for the treatment of acute diarrhea. However, few data from clinical trials are available.
136. Prognostic and clinical significance of syndecan-1 in colorectal cancer: a meta-analysis.
Syndecan-1 plays a vital role in the suppression, transformation, and migration of several cancer types, including colorectal cancer (CRC). However, the prognostic and clinical significance of syndecan-1 in CRC remains conflicting. Therefore, we performed a meta-analysis to clarify this relationship.
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