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128. Lifelong Physical Activity Regardless of Dose Is Not Associated With Myocardial Fibrosis.
作者: Shuaib M Abdullah.;Kyler W Barkley.;Paul S Bhella.;Jeffrey L Hastings.;Susan Matulevicius.;Naoki Fujimoto.;Shigeki Shibata.;Graeme Carrick-Ranson.;M Dean Palmer.;Nainesh Gandhi.;Laura F DeFina.;Benjamin D Levine.
来源: Circ Cardiovasc Imaging. 2016年9卷11期
Recent reports have suggested that long-term, intensive physical training may be associated with adverse cardiovascular effects, including the development of myocardial fibrosis. However, the dose-response association of different levels of lifelong physical activity on myocardial fibrosis has not been evaluated.
129. Greater Volume but not Higher Density of Abdominal Aortic Calcium Is Associated With Increased Cardiovascular Disease Risk: MESA (Multi-Ethnic Study of Atherosclerosis).
作者: Nketi I Forbang.;Erin D Michos.;Robyn L McClelland.;Rosemay A Remigio-Baker.;Matthew A Allison.;Veit Sandfort.;Joachim H Ix.;Isac Thomas.;Dena E Rifkin.;Michael H Criqui.
来源: Circ Cardiovasc Imaging. 2016年9卷11期
Abdominal aortic calcium (AAC) and coronary artery calcium (CAC) independently and similarly predict cardiovascular disease (CVD) events. The standard AAC and CAC score, the Agatston method, upweights for greater calcium density, thereby modeling higher calcium density as a CVD hazard.
130. Outcome Implication of Aortic Valve Area Normalized to Body Size in Asymptomatic Aortic Stenosis.
作者: Christophe Tribouilloy.;Yohann Bohbot.;Sylvestre Maréchaux.;Nicolas Debry.;Quentin Delpierre.;Marcel Peltier.;Momar Diouf.;Michel Slama.;David Messika-Zeitoun.;Dan Rusinaru.
来源: Circ Cardiovasc Imaging. 2016年9卷11期
Current guidelines define severe aortic stenosis in patients with aortic valve area normalized to body surface area (AVA/BSA) <0.6 cm2/m2; yet, this cutoff has never been validated. Moreover, it is not known whether AVA normalization to other body size indexes allows improved outcome prediction. We aim to test the value of AVA normalized to body size for outcome prediction in asymptomatic aortic stenosis.
131. Right Ventricular Dysfunction Impairs Effort Tolerance Independent of Left Ventricular Function Among Patients Undergoing Exercise Stress Myocardial Perfusion Imaging.
作者: Jiwon Kim.;Antonino Di Franco.;Tania Seoane.;Aparna Srinivasan.;Polydoros N Kampaktsis.;Alexi Geevarghese.;Samantha R Goldburg.;Saadat A Khan.;Massimiliano Szulc.;Mark B Ratcliffe.;Robert A Levine.;Ashley E Morgan.;Pooja Maddula.;Meenakshi Rozenstrauch.;Tara Shah.;Richard B Devereux.;Jonathan W Weinsaft.
来源: Circ Cardiovasc Imaging. 2016年9卷11期
Right ventricular (RV) and left ventricular (LV) function are closely linked due to a variety of factors, including common coronary blood supply. Altered LV perfusion holds the potential to affect the RV, but links between LV ischemia and RV performance, and independent impact of RV dysfunction on effort tolerance, are unknown.
132. Comprehensive Cardiovascular Magnetic Resonance Assessment in Patients With Sarcoidosis and Preserved Left Ventricular Ejection Fraction.
作者: Simon Greulich.;Daniel Kitterer.;Joerg Latus.;Eissa Aguor.;Hannah Steubing.;Philipp Kaesemann.;Alexandru Patrascu.;Andreas Greiser.;Stefan Groeninger.;Agnes Mayr.;Niko Braun.;M Dominik Alscher.;Udo Sechtem.;Heiko Mahrholdt.
来源: Circ Cardiovasc Imaging. 2016年9卷11期
Cardiac sarcoidosis (CS) may manifest as arrhythmia or even sudden cardiac death. Because patients with CS often present with nonspecific symptoms, normal electrocardiography, and preserved left ventricular ejection fraction, a reliable diagnostic tool for the work-up of CS is needed. Late gadolinium enhancement-cardiovascular magnetic resonance has proven diagnostic value in CS but has some limitations that may be overcome by adding newer cardiovascular magnetic resonance mapping techniques. The aim of our study was to evaluate a comprehensive cardiovascular magnetic resonance protocol, including late gadolinium enhancement and mapping sequences in sarcoid patients with no symptoms or unspecific symptoms and preserved left ventricular ejection fraction.
133. Persistent Microvascular Obstruction After Myocardial Infarction Culminates in the Confluence of Ferric Iron Oxide Crystals, Proinflammatory Burden, and Adverse Remodeling.
作者: Avinash Kali.;Ivan Cokic.;Richard Tang.;Alice Dohnalkova.;Libor Kovarik.;Hsin-Jung Yang.;Andreas Kumar.;Frank S Prato.;John C Wood.;David Underhill.;Eduardo Marbán.;Rohan Dharmakumar.
来源: Circ Cardiovasc Imaging. 2016年9卷11期
Emerging evidence indicates that persistent microvascular obstruction (PMO) is more predictive of major adverse cardiovascular events than myocardial infarct (MI) size. But it remains unclear how PMO, a phenomenon limited to the acute/subacute period of MI, drives adverse remodeling in chronic MI setting. We hypothesized that PMO resolves into chronic iron crystals within MI territories, which in turn are proinflammatory and favor adverse remodeling post-MI.
134. Magnetic Resonance Imaging of Cardiac Strain Pattern Following Transplantation of Human Tissue Engineered Heart Muscles.
作者: Xulei Qin.;Johannes Riegler.;Malte Tiburcy.;Xin Zhao.;Tony Chour.;Babacar Ndoye.;Michael Nguyen.;Jackson Adams.;Mohamed Ameen.;Thomas S Denney.;Phillip C Yang.;Patricia Nguyen.;Wolfram H Zimmermann.;Joseph C Wu.
来源: Circ Cardiovasc Imaging. 2016年9卷11期
The use of tissue engineering approaches in combination with exogenously produced cardiomyocytes offers the potential to restore contractile function after myocardial injury. However, current techniques assessing changes in global cardiac performance after such treatments are plagued by relatively low detection ability. Since the treatment is locally performed, this detection could be improved by myocardial strain imaging that measures regional contractility.
135. High Structural Stress and Presence of Intraluminal Thrombus Predict Abdominal Aortic Aneurysm 18F-FDG Uptake: Insights From Biomechanics.
作者: Yuan Huang.;Zhongzhao Teng.;Maysoon Elkhawad.;Jason M Tarkin.;Nikhil Joshi.;Jonathan R Boyle.;John R Buscombe.;Timothy D Fryer.;Yongxue Zhang.;Ah Yeon Park.;Ian B Wilkinson.;David E Newby.;Jonathan H Gillard.;James H F Rudd.
来源: Circ Cardiovasc Imaging. 2016年9卷11期e004656页
Abdominal aortic aneurysm (AAA) wall inflammation and mechanical structural stress may influence AAA expansion and lead to rupture. We hypothesized a positive correlation between structural stress and fluorine-18-labeled 2-deoxy-2-fluoro-d-glucose (18F-FDG) positron emission tomography-defined inflammation. We also explored the influence of computed tomography-derived aneurysm morphology and composition, including intraluminal thrombus, on both variables.
136. Percutaneous Coronary Intervention Using Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Stenosis: A Meta-Analysis of Randomized Trials.
作者: Nitesh Nerlekar.;Francis J Ha.;Kunal P Verma.;Martin R Bennett.;James D Cameron.;Ian T Meredith.;Adam J Brown.
来源: Circ Cardiovasc Interv. 2016年9卷12期
Current guidelines suggest that coronary artery bypass grafting (CABG) should be the preferred revascularization method for unprotected left main coronary artery stenosis. In light of evidence from recent randomized trials, we assessed whether percutaneous coronary intervention (PCI) using drug-eluting stents is as safe and effective as CABG for the treatment of unprotected left main coronary artery disease.
137. The IMPACT Study (Influence of Sensor-Equipped Microcatheters on Coronary Hemodynamics and the Accuracy of Physiological Indices of Functional Stenosis Severity).
作者: Gilbert W M Wijntjens.;Tim P van de Hoef.;Robin P Kraak.;Marcel A Beijk.;Krischan D Sjauw.;M Marije Vis.;Maribel I Madera Cambero.;Stijn L Brinckman.;Jacobus Plomp.;Jan Baan.;Karel T Koch.;Joanna J Wykrzykowska.;José P Henriques.;Robbert J de Winter.;Jan J Piek.
来源: Circ Cardiovasc Interv. 2016年9卷12期
The Navvus pressure sensor-equipped microcatheter allows to measure functional stenosis severity over a work-horse guidewire and is used as a more feasible alternative to regular sensor-equipped wires. However, Navvus is larger in diameter than contemporary sensor-equipped guidewires and may, thereby, influence functional measurements. The present study evaluates the hemodynamic influence of the Navvus microcatheter.
138. Twenty-Year Outcome After Mitral Repair Versus Replacement for Severe Degenerative Mitral Regurgitation: Analysis of a Large, Prospective, Multicenter, International Registry.
作者: Siham Lazam.;Jean-Louis Vanoverschelde.;Christophe Tribouilloy.;Francesco Grigioni.;Rakesh M Suri.;Jean-Francois Avierinos.;Christophe de Meester.;Andrea Barbieri.;Dan Rusinaru.;Antonio Russo.;Agnès Pasquet.;Hector I Michelena.;Marianne Huebner.;Joseph Maalouf.;Marie-Annick Clavel.;Catherine Szymanski.;Maurice Enriquez-Sarano.; .
来源: Circulation. 2017年135卷5期410-422页
Mitral valve (MV) repair is preferred over replacement in clinical guidelines and is an important determinant of the indication for surgery in degenerative mitral regurgitation. However, the level of evidence supporting current recommendations is low, and recent data cast doubts on its validity in the current era. Accordingly, the aim of the present study was to analyze very long-term outcome after MV repair and replacement for degenerative mitral regurgitation with a flail leaflet.
139. Functional Definition of Progenitors Versus Mature Endothelial Cells Reveals Key SoxF-Dependent Differentiation Process.
作者: Jatin Patel.;Elke J Seppanen.;Mathieu P Rodero.;Ho Yi Wong.;Prudence Donovan.;Zoltan Neufeld.;Nicholas M Fisk.;Mathias Francois.;Kiarash Khosrotehrani.
来源: Circulation. 2017年135卷8期786-805页
During adult life, blood vessel formation is thought to occur via angiogenic processes involving branching from existing vessels. An alternate proposal suggests that neovessels form from endothelial progenitors able to assemble the intimal layers. We here aimed to define vessel-resident endothelial progenitors in vivo in a variety of tissues in physiological and pathological situations such as normal aorta, lungs, and wound healing, tumors, and placenta, as well.
140. Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention.
作者: Sanjoy K Chowdhury.;Wei Liu.;Min Zi.;Yatong Li.;Shunyao Wang.;Hoyee Tsui.;Sukhpal Prehar.;Simon Castro.;Henggui Zhang.;Yong Ji.;Xiuqin Zhang.;Ruiping Xiao.;Rongli Zhang.;Ming Lei.;Lukas Cyganek.;Kaomei Guan.;Catherine B Millar.;Xudong Liao.;Mukesh K Jain.;Mark R Boyett.;Elizabeth J Cartwright.;Holly A Shiels.;Xin Wang.
来源: Circulation. 2017年135卷7期683-699页
Ventricular arrhythmia is a leading cause of cardiac mortality. Most antiarrhythmics present paradoxical proarrhythmic side effects, culminating in a greater risk of sudden death.
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